{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:41:33Z","timestamp":1770990093720,"version":"3.50.1"},"reference-count":19,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1969,10]]},"abstract":"<jats:p>The incidence, clinical and investigative features, treatment, and course of severe oesophagitis in 200 patients seen and followed up in the Thoracic Surgical Department for north east Scotland from 1951 to 1967 are reviewed. The male\/female ratio was 1\/1\u00b79. The incidence of severe oesophagitis (grades III and IV) approximated to 4\u00b75 per 100,000; there was a dramatic increase from the age of 50 years onwards.<\/jats:p>\n                  <jats:p>Reflux, with or without hiatal hernia, precedes oesophagitis and has an incidence in excess of 86 per 100,000. It is difficult to assess the extent to which reflux produces mild oesophagitis, but it is clear that it only infrequently leads to the severe grades.<\/jats:p>\n                  <jats:p>Severe oesophagitis does not always need operative treatment. A conservative regime, supplemented by bouginage as required, enables the poorer-risk older patient to live a near-normal life span, in very reasonable comfort. Fifty-three patients of the whole series were operated upon, half primarily and half after previous conservative treatment. The problems of operative treatment are discussed. Newer procedures designed to prevent reflux now allow operation to be more freely advised.<\/jats:p>\n                  <jats:p>Perhaps, rather surprisingly, severe oesophagitis had very little effect on the expectation of life, whether treatment was conservative or operative.<\/jats:p>","DOI":"10.1136\/gut.10.10.831","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"831-837","source":"Crossref","is-referenced-by-count":58,"title":["Severe peptic oesophagitis"],"prefix":"10.1136","volume":"10","author":[{"given":"P. L.","family":"Brunnen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Karmody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. D.","family":"Needham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1969,10,1]]},"reference":[{"key":"ref_1","first-page":"419","article-title":"Reflux esophagitis, sliding hiatal hernia, and the anatomy of repair","volume":"92","author":"Allison, P.R.","year":"1951","unstructured":"Allison, P. R. (1951). Reflux esophagitis, sliding hiatal hernia, and the anatomy of repair. Surg. Gynec. Obstet., 92, 419-431.","journal-title":"Surg. Gynec. Obstet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0022-5223(19)33009-0","article-title":"Benign stricture in the lower esophagus","volume":"43","author":"Barrett, N.R.","year":"1962","unstructured":"Barrett, N. R. (1962). Benign stricture in the lower esophagus. J. thorac. cardiovasc. Surg., 43, 703-715.","journal-title":"J. thorac. cardiovasc. Surg"},{"key":"ref_3","first-page":"932","article-title":"Benign strictures of the oesophagus","volume":"59","author":"Belsey, R.","year":"1966","unstructured":"Belsey, R. (1966). Benign strictures of the oesophagus. Proc. roy. Soc. Med., 59, 932-933.","journal-title":"Proc. roy. Soc. Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S0140-6736(66)90472-7","article-title":"Oesophageal acid-perfusion in the diagnosis of precordial pain","volume":"2","author":"Bennett, J.R.; Atkinson, M.","year":"1966","unstructured":"Bennett, J. R., and Atkinson, M. (1966). Oesophageal acid-perfusion in the diagnosis of precordial pain. Lancet, 2, 1150-1152.","journal-title":"Lancet"},{"key":"ref_5","first-page":"496","author":"Berne, C.J.","year":"1964","unstructured":"Berne, C. J. (1964). In Hernia, edited by L. M. Nyhus and H. N. Harkins, pp. 496-498. Pitman, London."},{"key":"ref_6","first-page":"929","article-title":"Peptic strictures of the oesophagus associated with duodenal ulcer, and operations for its relief","volume":"59","author":"Brain, R.","year":"1966","unstructured":"Brain, R. (1966). Peptic strictures of the oesophagus associated with duodenal ulcer, and operations for its relief. Proc. roy. Soc. Med., 59, 929-931.","journal-title":"Proc. roy. Soc. Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/thx.21.1.67","article-title":"Symptomatic hiatus hernia","volume":"21","author":"Burge, H.W.; Gill, A.M.; MacLean, C.D.T.; Lewis, R.H.","year":"1966","unstructured":"Burge, H. W., Gill, A. M., MacLean, C. D. T., and Lewis, R. H. (1966). Symptomatic hiatus hernia. Thorax, 21, 67-74.","journal-title":"Thorax"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/pgmj.44.514.579","article-title":"Hiatal hernia","volume":"44","author":"Davidson, J.S.","year":"1968","unstructured":"Davidson, J. S. (1968). Hiatal hernia. Postgrad. med. 1., 44, 579-585.","journal-title":"Postgrad. med. 1"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0022-5223(20)31923-1","article-title":"Incompetency of the gastric cardia without radiologic evidence of hiatal hernia","volume":"42","author":"Hiebert, C.A.; Belsey, R.","year":"1961","unstructured":"Hiebert, C. A., and Belsey, R. (1961). Incompetency of the gastric cardia without radiologic evidence of hiatal hernia. J. thorac. cardiovasc. Surg., 42, 352-362.","journal-title":"J. thorac. cardiovasc. Surg"},{"key":"ref_10","first-page":"94","article-title":"Esophageal hiatal hernia","volume":"113","author":"Hill, L.D.","year":"1967","unstructured":"Hill, L. D. (1967). Esophageal hiatal hernia. Amer. J. Surg., 113, 94-97.","journal-title":"Amer. J. Surg"},{"key":"ref_11","article-title":"The Cardia and Hiatus Hernia","author":"Johnson, H.","year":"1968","unstructured":"Johnson, H. Daintree (1968). The Cardia and Hiatus Hernia. Heinemann, London.","journal-title":"Daintree"},{"key":"ref_12","first-page":"488","article-title":"The treatment of hiatal hernia and esophageal reflux by fundoplication","author":"Nissen, R.","year":"1964","unstructured":"Nissen, R. (1964). The treatment of hiatal hernia and esophageal reflux by fundoplication. In Hernia, edited by L. M. Nyhus and H. N. Harkins, pp. 488-496. Pitman, London."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1001\/jama.1961.03040420011003","article-title":"Esophageal hiatal hernia: a 10-year study of medically treated cases","volume":"178","author":"Rex, J.C.; Andersen, H.A.; Bartholomew, L.G.; Cain, J.C.","year":"1961","unstructured":"Rex, J. C., Andersen, H. A., Bartholomew, L. G., and Cain, J. C. (1961). Esophageal hiatal hernia: a 10-year study of medically treated cases. J. Amer. med. Ass., 178, 271-274.","journal-title":"J. Amer. med. Ass"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0022-5223(19)43239-X","article-title":"Surgical management of esophageal reflux and hiatus hernia","volume":"53","author":"Skinner, D.B.; Belsey, R.H.R.","year":"1967","unstructured":"Skinner, D. B., and Belsey, R. H. R. (1967). Surgical management of esophageal reflux and hiatus hernia. J. thorac. cardiovasc. Surg., 53, 33-54.","journal-title":"J. thorac. cardiovasc. Surg"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1177\/003591576605901004","article-title":"Stricture of the lower oesophagus","volume":"59","author":"Tanner, N.C.","year":"1966","unstructured":"Tanner, N. C. (1966). Stricture of the lower oesophagus. Proc. roy. Soc. Med., 59, 933.","journal-title":"Proc. roy. Soc. 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D., and Backett, E. M. (1968). Studies of the epidemiology of peptic ulcer in a rural community: prevalence and natural history of dyspepsia and peptic ulcer. Gut, 9, 75-83.","journal-title":"Gut"},{"key":"ref_19","first-page":"665","article-title":"Diaphragmatic hernia and allied conditions: radiologic aspects","volume":"67","author":"Wolf, B.S.","year":"1967","unstructured":"Wolf, B. S. (1967). Diaphragmatic hernia and allied conditions: radiologic aspects. N. Y. St. J. Med., 67, 665-667.","journal-title":"N. Y. St. J. 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