{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:13:26Z","timestamp":1765602806990,"version":"3.48.0"},"reference-count":14,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1969,10]]},"abstract":"<jats:p>Intraluminal manometric studies performed on 12 patients with chronic Chagas disease and megacolon without clinical or radiological abnormalities of the oesophagus showed no alteration in oesophageal physiology under basal conditions when compared with a control group of 30 healthy subjects. Oesophageal peristalsis was unimpaired.<\/jats:p>\n                  <jats:p>Patients with chronic Chagas disease and megacolon differed from normals in their reaction to a small dose of a cholinergic drug. This agent induced an isolated but significant increase in resting pressure at the level of the oesophagogastric sphincter, accompanied in most cases by an increase in spontaneous activity but not by a change in resting pressure in the body of the oesophagus. This is interpreted as a subclinical expression of oesophageal pathology related to Chagas disease.<\/jats:p>","DOI":"10.1136\/gut.10.10.848","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"848-851","source":"Crossref","is-referenced-by-count":19,"title":["Oesophageal manometric studies in patients with chronic Chagas disease and megacolon"],"prefix":"10.1136","volume":"10","author":[{"given":"Peter","family":"Heitmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1969,10,1]]},"reference":[{"key":"ref_1","first-page":"94","article-title":"Megacolon y enfermedad de Chagas","volume":"88","author":"Atlas, A.; Neghme, A.; Aguirre MacKay, L.; Herrera, E.","year":"1960","unstructured":"Atlas, A., Neghme, A., Aguirre MacKay, L., and Herrera, E. (1960). Megacolon y enfermedad de Chagas. Rev Med. Chile, 88, 94-97.","journal-title":"Rev Med. Chile"},{"key":"ref_2","first-page":"433","article-title":"Megaesophagus, megacolon, and Chagas'","volume":"44","author":"Atlas, A.; Neghme, A.; Aguirre MacKay, L.; Herrera, E.; Jarpa, S.","year":"1963","unstructured":"Atlas, A., Neghme, A., Aguirre MacKay, L., and Herrera, E., and Jarpa, S. (1963). Megaesophagus, megacolon, and Chagas' disease in Chile. Gastroenterology, 44, 433-437.","journal-title":"disease in Chile. Gastroenterology"},{"key":"ref_3","first-page":"1555","article-title":"Le m6gaoesophage, cardiospasme r6actionnel. Donn6es 6lectromanographiques et cineradiom6triques","volume":"38","author":"Besangon, F.; Janin, B.; Debray, C.","year":"1962","unstructured":"Besangon, F., Janin, B., and Debray, C. (1962). Le m6gaoesophage, cardiospasme r6actionnel. Donn6es 6lectromanographiques et cineradiom6triques. Sem. Hop. Paris, 38, 1555.1564.","journal-title":"Sem. Hop. Paris"},{"key":"ref_4","first-page":"117","article-title":"Diagn6stico da esophagopatia chagasica chr6nica assintomatica nao ectisica","volume":"9","author":"Godoy, R.A.; Vieira, C.B.","year":"1963","unstructured":"Godoy, R. A., and Vieira, C. B. (1963). Diagn6stico da esophagopatia chagasica chr6nica assintomatica nao ectisica. Rev. goiana Med., 9, 117-124.","journal-title":"Rev. goiana Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0016-5085(66)80002-1","article-title":"Simultaneous cineradiographic-manometric study of the distal esophagus: small hiatal hernias and rings","volume":"50","author":"Heitmann, P.; Wolf, B.S.; Sokol, E.M.; Cohen, B.R.","year":"1966","unstructured":"Heitmann, P., Wolf, B. S., Sokol, E. M., and Cohen, B. R. (1966). Simultaneous cineradiographic-manometric study of the distal esophagus: small hiatal hernias and rings. Gastroenterology, 50, 737-753.","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00365526909180144","article-title":"Physiology of the distal oesophagus in achalasia","volume":"4","author":"Heitmann, P.; Wolf, B.S.; Sokol, E.M.; Cohen, B.R.; Espinoza, J.; Csendes, A.","year":"1969","unstructured":"Heitmann, P., Wolf, B. S., Sokol, E. M., and Cohen, B. R., Espinoza, J., and Csendes, A. (1969). Physiology of the distal oesophagus in achalasia. Scand. J. Gastroent., 4, 1-11.","journal-title":"Scand. J. Gastroent"},{"key":"ref_7","first-page":"5","article-title":"Resultados obtenidos con la reacci6n de fijaci6n del complemento segun el SOY. de hem6lisis en el diagn6stico de la enfermedad de Chagas","volume":"14","author":"Knierim, F.","year":"1959","unstructured":"Knierim, F. (1959). Resultados obtenidos con la reacci6n de fijaci6n del complemento segun el SOY. de hem6lisis en el diagn6stico de la enfermedad de Chagas. Bol. chil. Parasit., 14, 5-6.","journal-title":"Bol. chil. Parasit"},{"key":"ref_8","first-page":"\"404","article-title":"Patologia y anatomia patol6gica de la enfermedad de Chagas. Bol. Ofic. sanit","volume":"51","author":"Koberle, F.","year":"1961","unstructured":"Koberle, F. (1961). Patologia y anatomia patol6gica de la enfermedad de Chagas. Bol. Ofic. sanit. panamer., 51, 404-428. Kramer. P., and Ingelfinger, F. J. (1951). Esophageal sensitivity to Mecholyl in cardiospasm. Gastroenterology. 19, 242-253., Fleshles B.. McNally, E., and Harris, L. D. (1967). Oesophageal sensitivity to Mecholyl in symptomatic diffuse spasm. Gut, 8, 120-127.","journal-title":"panamer; Esophageal sensitivity to Mecholyl in cardiospasm"},{"key":"ref_9","first-page":"29","article-title":"Alteragoes da dinamica esofagiana na fase cr6nica da molestia de Chagas","volume":"9","author":"Pessoa, J.; Mesquita, C.de","year":"1963","unstructured":"Pessoa, J., and Mesquita, C. de. (1963). Alteragoes da dinamica esofagiana na fase cr6nica da molestia de Chagas. Rev. goiana Med., 9, 29-44.","journal-title":"Rev. goiana Med"},{"key":"ref_10","first-page":"1","article-title":"Comprometimento do es6fago na molestia de Chagas","author":"Rezende, J.M.; Rassi, A.","year":"1958","unstructured":"Rezende, J. M., and Rassi, A. (1958). Comprometimento do es6fago na molestia de Chagas. Hospital (Rio de J.), 53, 1-15."},{"key":"ref_11","first-page":"390","article-title":"Epidemiologia y distribuci6n geografica de la enfermedad de Chagas. Bol Ofic. sanit","volume":"51","author":"Romania, C.","year":"1961","unstructured":"Romania, C. (1961). Epidemiologia y distribuci6n geografica de la enfermedad de Chagas. Bol Ofic. sanit. Panamer., 51, 390-403. Siffert de Paula e Silva, G. (1959). Digestive forms of Chagas' disease.","journal-title":"Panamer; Digestive forms of Chagas' disease"},{"key":"ref_12","article-title":"Statistical Methods","author":"Snedecor, G.W.","year":"1956","unstructured":"Snedecor, G. W. (1956). Statistical Methods. Iowa State University"},{"key":"ref_13","first-page":"21","article-title":"Resposta motora do es6fago nao ectisico a agentes colinergicos na molestia de Chagas","volume":"9","author":"Press, Ames; Iowa. Vieira, C.G.; Godoy, R.A.","year":"1963","unstructured":"Press, Ames, Iowa. Vieira, C. G., and Godoy, R. A. (1963). Resposta motora do es6fago nao ectisico a agentes colinergicos na molestia de Chagas. Rev. golana Med., 9, 21-28.","journal-title":"Rev. golana Med"},{"key":"ref_14","first-page":"738","article-title":"A method for the roentgen demonstration of minimal hiatal herniation","volume":"23","author":"Wolf, B.S.; Guglielmo, J.","year":"1956","unstructured":"Wolf, B. S., and Guglielmo, J. (1956). A method for the roentgen demonstration of minimal hiatal herniation. J. Mt. Sinai Hosp., 23, 738-741.","journal-title":"J. Mt. Sinai Hosp"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.10.10.848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:10:18Z","timestamp":1765602618000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.10.10.848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,10]]},"references-count":14,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1969,10,1]]},"published-print":{"date-parts":[[1969,10]]}},"alternative-id":["10.1136\/gut.10.10.848"],"URL":"https:\/\/doi.org\/10.1136\/gut.10.10.848","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1969,10]]}}}