{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T08:17:44Z","timestamp":1765613864171,"version":"3.48.0"},"reference-count":9,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1969,11]]},"abstract":"<jats:p>It has been demonstrated that cardiac output and pulmonary, gastroduodenal, pancreatic, and splenic blood flow increases after portacaval shunt operations. This report concerns a study of cerebral haemodynamics and metabolism in eight patients with cirrhosis of the liver, examined both before and after portacaval surgical anastomosis. The patients were fully alert and orientated to mental and neurological examination at all times.<\/jats:p>\n                  <jats:p>In each subject the cerebral blood flow, cerebral vascular resistance, cerebral metabolic rate of oxygen and of glucose, and glucose\/oxygen quotient were determined.<\/jats:p>\n                  <jats:p>This investigation showed that a portacaval shunt operation is followed by a significant increase in the cerebral blood flow and a significant decrease in the cerebral vascular resistances. No important variation in the cerebral metabolic rate of oxygen was observed, but both the cerebral metabolic rate of glucose and the glucose: oxygen quotient showed significant increases.<\/jats:p>\n                  <jats:p>The presence of toxic substances which, shunting the liver, enter the general circulation could be the cause of the increased cerebral blood flow, while the increase in the cerebral metabolic rate of glucose could result from a greater cerebral detoxication, for example, the cerebral synthesis of glutamine.<\/jats:p>","DOI":"10.1136\/gut.10.11.894","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"894-897","source":"Crossref","is-referenced-by-count":25,"title":["Cerebral blood flow and metabolism in hepatic cirrhosis before and after portacaval shunt operation"],"prefix":"10.1136","volume":"10","author":[{"given":"G. Bianchi","family":"Porro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. T.","family":"Maiolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Della","family":"Porta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1969,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1001\/jama.1965.03080180043010","article-title":"Portacaval shunting and upper gastrointestinal blood flow","volume":"192","year":"1965","unstructured":"Delancy, J. P., Goodale, R. L., Jr., Cheng, J., and Wangensteen, 0. H. (1965). Portacaval shunting and upper gastrointestinal blood flow. J. Amer. med. Ass., 192, 385-386.","journal-title":"J. Amer. med. Ass"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0002-8703(64)90003-1","article-title":"Circulatory hemodynamics before and after portacaval shunt operation in bilharzial hepatic fibrosis","volume":"67","author":"Foda, H.; Badawi, H.; Salah, M.","year":"1964","unstructured":"Foda, H., Badawi, H., and Salah, M. (1964). Circulatory hemodynamics before and after portacaval shunt operation in bilharzial hepatic fibrosis. Amer. Heart J., 67. 295-303.","journal-title":"Amer. Heart J"},{"key":"ref_3","article-title":"Splenic blood flow and resistance in patients with well compensated cirrhosis before and after portacaval anastomosis","volume-title":"In","author":"Gitlin, N.; Grahame, G.R.; Kreel, L.; Sherlock, S.","year":"1968","unstructured":"Gitlin, N., Grahame, G. R., Kreel, L., and Sherlock, S. (1968). Splenic blood flow and resistance in patients with well compensated cirrhosis before and after portacaval anastomosis. In"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0140-6736(57)92595-3","article-title":"Use of glucose oxidase, peroxidase, and o-dianisidine in determination of blood and urinary glucose","volume":"2","author":"Huggett, A.St G.; Nixon, D.A.","year":"1957","unstructured":"Huggett, A. St. G., and Nixon, D. A. (1957). Use of glucose oxidase, peroxidase, and o-dianisidine in determination of blood and urinary glucose. Lancet, 2, 368-370.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1172\/JCI101994","article-title":"The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values","volume":"27","author":"Kety, S.S.; Schmidt, C.F.","year":"1948","unstructured":"Kety, S. S., and Schmidt, C. F. (1948). The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J. clin. Invest., 27, 476-483.","journal-title":"J. clin. Invest"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1172\/JCI102813","article-title":"The cardiac output at rest in Laennec's cirrhosis","volume":"32","author":"Kowalski, H.J.; Abelmann, W.H.","year":"1953","unstructured":"Kowalski, H. J., and Abelmann, W. H. (1953). The cardiac output at rest in Laennec's cirrhosis. J. clin. Invest., 32, 1025-1033.","journal-title":"J. clin. Invest"},{"key":"ref_7","first-page":"712","article-title":"Discussion. Tavola rotonda sulle metodiche per lo studio del circolo viscerale","volume":"9","author":"Nylin, G.","year":"1961","unstructured":"Nylin, G. (1961). Discussion. Tavola rotonda sulle metodiche per lo studio del circolo viscerale. Minerva cardioangiol., 9, 712-716 and 734.","journal-title":"Minerva cardioangiol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0021-9258(18)85145-6","article-title":"The determination of gases in blood and other solutions by vacuum extraction and manometric measurement","volume":"61","author":"Van Slyke, D.D.; Neill, J.M.","year":"1924","unstructured":"Van Slyke, D. D., and Neill, J. M. (1924). The determination of gases in blood and other solutions by vacuum extraction and manometric measurement. J. biol. Chem., 61, 523-573.","journal-title":"J. biol. Chem"},{"key":"ref_9","article-title":"The action of drugs on the cerebral circulation","author":"Sokoloff, L.","year":"1959","unstructured":"Sokoloff, L. (1959). The action of drugs on the cerebral circulation."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.10.11.894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T08:14:58Z","timestamp":1765613698000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.10.11.894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,11]]},"references-count":9,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1969,11,1]]},"published-print":{"date-parts":[[1969,11]]}},"alternative-id":["10.1136\/gut.10.11.894"],"URL":"https:\/\/doi.org\/10.1136\/gut.10.11.894","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1969,11]]}}}