{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:48:59Z","timestamp":1765608539643,"version":"3.48.0"},"reference-count":27,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1969,11]]},"abstract":"<jats:p>A case of carcinoma of the small bowel intimately associated with long-standing regional enteritis (Crohn's disease) is described. Sixteen similar cases reported in the literature are briefly reviewed. This neoplasm presents at a younger age than other small bowel carcinomas and there seems little doubt that it is causally related to the inflammatory bowel lesion.<\/jats:p>","DOI":"10.1136\/gut.10.11.924","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"924-927","source":"Crossref","is-referenced-by-count":34,"title":["Regional enteritis leading to carcinoma of the small bowel"],"prefix":"10.1136","volume":"10","author":[{"given":"A. P.","family":"Wyatt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1969,11,1]]},"reference":[{"key":"ref_1","first-page":"452","article-title":"Regional ileitis with coincident ileal carcinoma","volume":"57","author":"Almond, C.H.; Neal, M.P.; Moedl, K.R.","year":"1960","unstructured":"Almond, C. H., Neal, M. P., and Moedl, K. R. (1960). Regional ileitis with coincident ileal carcinoma. Missouri Med., 57, 452-453.","journal-title":"Missouri Med"},{"key":"ref_2","first-page":"30","article-title":"Adenocarcinoma ofthesmall intestine occurring in a case of regional enteritis","volume":"31","author":"Berman, L.G.; Prior, J.T.","year":"1964","unstructured":"Berman, L. G., and Prior, J. T. (1964). Adenocarcinoma ofthesmall intestine occurring in a case of regional enteritis. J. Mt. Sinai Hosp., 31, 30-37.","journal-title":"J. Mt. Sinai Hosp"},{"issue":"703-710","key":"ref_3","article-title":"A unique case with roentgenologic evidence of regional enteritis of long duration and histologic evidence of diffuse adenocarcinoma","volume":"34","author":"Bersack, S.R.; Howe, J.S.; Rehak, E.M.","year":"1958","unstructured":"Bersack, S. R., Howe, J. S., and Rehak, E. M. (1958). A unique case with roentgenologic evidence of regional enteritis of long duration and histologic evidence of diffuse adenocarcinoma. Gastroenterology, 34,703-710.","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/bjs.1800550602","article-title":"Malignant lesions of the small intestine: a ten-year survey","volume":"55","author":"Brookes, V.S.; Waterhouse, J.A.H.; Powell, D.J.","year":"1968","unstructured":"Brookes, V. S., Waterhouse, J. A. H., and Powell, D. J. (1968). Malignant lesions of the small intestine: a ten-year survey. Brit. J. Surg., 55, 405-410.","journal-title":"Brit. J. Surg"},{"key":"ref_5","article-title":"Personal communication","author":"Brookes, V.S.; Waterhouse, J.A.H.; Powell, D.J.","year":"1968","unstructured":"Brookes, V. S., Waterhouse, J. A. H., and Powell, D. J. (1968). Personal communication."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0002-9610(59)90313-7","article-title":"Carcinoma of the ileum occurring in an area of regional enteritis","volume":"97","author":"Buchanan, D.P.; Huebner, G.D.; Woolvin, S.C.; North, S.C.; Novack, T.D.","year":"1959","unstructured":"Buchanan, D. P., Huebner, G. D., Woolvin, S. C., North, S. C., and Novack, T. D. (1959). Carcinoma of the ileum occurring in an area of regional enteritis. Amer. J. Surg., 97, 336-339.","journal-title":"Amer. J. Surg"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0016-5085(68)80075-7","article-title":"Adenocarcinoma complicating regional enteritis: report of a case and review of the literature","volume":"54","author":"Cantwell, J.D.; Kettering, R.F.; Carney, J.A.; Ludwig, J.","year":"1968","unstructured":"Cantwell, J. D., Kettering, R. F., Carney, J. A., and Ludwig, J. (1968). Adenocarcinoma complicating regional enteritis: report of a case and review of the literature. Gastroenterology, 54, 599-604.","journal-title":"Gastroenterology"},{"key":"ref_8","first-page":"74","article-title":"Regional Enteritis","volume-title":"Personal Communication","author":"Crohn, B.B.; Yarnis, H.","year":"1958","unstructured":"Crohn, B. B., and Yarnis, H. (1958). Regional Enteritis, 2nd ed., p. 74. Grune and Stratton, New York. Curwen, M. P. (1968). Personal Communication.","edition":"2nd ed"},{"key":"ref_9","first-page":"1","article-title":"Local complications of ulcerative colitis: stricture, pseudopolyposis, and carcinoma of colon and rectum","author":"De Dombal, F.T.; Watts, J.McK; Watkinson, G.; Goligher, J.C.","year":"1966","unstructured":"De Dombal, F. T., Watts, J. McK., Watkinson, G., and Goligher, J. C. (1966). Local complications of ulcerative colitis: stricture, pseudopolyposis, and carcinoma of colon and rectum. Brit. med. J., 1,1442-1447.","journal-title":"Brit. med. J"},{"key":"ref_10","first-page":"347","article-title":"Carcinoma of the jejunum occurring in a case of regional enteritis","volume":"39","author":"Ginzburg, L.; Schneider, K.M.; Dreizin, D.H.; Levinson, C.","year":"1956","unstructured":"Ginzburg, L., Schneider, K. M., Dreizin, D. H., and Levinson, C. (1956). Carcinoma of the jejunum occurring in a case of regional enteritis. Surgery, 39, 347-351.","journal-title":"Surgery"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1177\/003591576605900725","article-title":"Carcinoma in ulcerative colitis","volume":"59","author":"Hinton, J.M.","year":"1966","unstructured":"Hinton, J. M. (1966). Carcinoma in ulcerative colitis. Proc. roy. Soc. Med., 59, 632-633.","journal-title":"Proc. roy. Soc. Med"},{"key":"ref_12","first-page":"63","article-title":"Adenocarcinoma of the terminal ileum in a segment of bowel with coexisting active ileitis","author":"Hoffert, P.W.; Weingarten, B.; Friedman, L.D.; Morecki, R.","year":"1963","unstructured":"Hoffert, P. W., Weingarten, B., Friedman, L. D., and Morecki, R. (1963). Adenocarcinoma of the terminal ileum in a segment of bowel with coexisting active ileitis. New York Med. J., 63,1567-1571.","journal-title":"New York Med. J"},{"key":"ref_13","first-page":"770","article-title":"Reticulum cell sarcoma: a case possibly originating in regional enteritis","volume":"21","author":"Hughes, R.K.","year":"1955","unstructured":"Hughes, R. K. (1955). Reticulum cell sarcoma: a case possibly originating in regional enteritis. Amer. Surg., 21, 770-773.","journal-title":"Amer. Surg"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0002-9343(57)90328-5","article-title":"Adenocarcinoma occurring in regional jejunitis","volume":"23","author":"Kornfeld, P.; Ginsburg, L.; Aldersburg, D.","year":"1957","unstructured":"Kornfeld, P., Ginsburg, L., and Aldersburg, D. (1957). Adenocarcinoma occurring in regional jejunitis. Amer. J. Med., 23, 493-498.","journal-title":"Amer. J. Med"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0016-5085(19)34050-8","article-title":"Adenocarcinoma of the ileum complicating chronic enteritis","volume":"55","author":"Morowitz, D.A.; Block, G.E.; Kirsner, J.B.","year":"1968","unstructured":"Morowitz, D. A., Block, G. E., Kirsner, J. B. (1968). Adenocarcinoma of the ileum complicating chronic enteritis. Gastroenterology, 55, 397-402.","journal-title":"Gastroenterology"},{"key":"ref_16","article-title":"Personal communication","author":"Murray, I.","year":"1968","unstructured":"Murray, I. (1968). Personal communication."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1136\/bmj.2.5603.466","article-title":"Crohn's disease and carcinoma of colon","volume":"2","author":"Perrett, A.D.; Truelove, S.C.; Massarella, G.R.","year":"1968","unstructured":"Perrett, A. D., Truelove, S. C., and Massarella, G. R. (1968). Crohn's disease and carcinoma of colon. Brit. med. J., 2, 466-468.","journal-title":"Brit. med. J"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/bjs.1800550117","article-title":"Adenocarcinoma associated with Crohn's disease","volume":"55","author":"Sheil, F.O.'M.; Clark, C.G.; Goligher, J.C.","year":"1968","unstructured":"Sheil, F. O'M., Clark, C. G., and Goligher, J. C. (1968). Adenocarcinoma associated with Crohn's disease. Brit. J. Surg., 55, 53-68.","journal-title":"Brit. J. Surg"},{"issue":"379-38","key":"ref_19","first-page":"1","article-title":"Adenocarcinoma arising in a site of chronic regional enteritis","volume":"83","author":"Steele, D.C.; McNeely, D.T.","year":"1960","unstructured":"Steele, D. C., and McNeely, D. T. (1960). Adenocarcinoma arising in a site of chronic regional enteritis. Canad. med. Ass. J., 83, 379-38 1.","journal-title":"Canad. med. Ass. J"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/00000658-196904000-00006","article-title":"Adenocarcinoma of the small intestine and othes malignant tumors complicating regional enteritis","volume":"169","year":"1969","unstructured":"Tyers, G. F. 0., Steiger, E., and Dudrick, S. J. (1969). Adenocarcinoma of the small intestine and othes malignant tumors complicating regional enteritis. Ann. Surg., 169, 510-518.","journal-title":"Ann. Surg"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1001\/archsurg.1959.04320030127021","article-title":"Adenocarcinoma of the jejunum in nonspecific granulomatous enteritis","volume":"78","author":"Weingarten, B.; Parker, J.G.; Chazen, E.M.; Jacobson, H.G.","year":"1959","unstructured":"Weingarten, B., Parker, J. G., Chazen, E. M., and Jacobson, H. G. (1959). Adenocarcinoma of the jejunum in nonspecific granulomatous enteritis. Arch. Surg., 78, 483-489.","journal-title":"Arch. Surg"},{"key":"ref_22","first-page":"203","article-title":"Malignant degeneration in chronic inflammatory disease of the colon and small intestine","volume":"33","author":"Weingarten, B.; Parker, J.G.; Chazen, E.M.; Jacobson, H.G.; Weiss, J.","year":"1960","unstructured":"Weingarten, B., Parker, J. G., Chazen, E. M., and Jacobson, H. G. and Weiss, J. (1960). Malignant degeneration in chronic inflammatory disease of the colon and small intestine. Amer. J. Gastroent., 33, 203-207.","journal-title":"Amer. J. Gastroent"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1136\/bmj.2.5606.697-a","article-title":"Crohn's disease and carcinoma of colon","volume":"2","author":"Wyburn-Mason, R.","year":"1968","unstructured":"Wyburn-Mason, R. (1968). Crohn's disease and carcinoma of colon. (Letter). Brit. med. J., 2, 697.","journal-title":"(Letter). Brit. med. J"},{"key":"ref_24","first-page":"970","article-title":"Regional enteritis complicated by adenocarcinoma of the ileum: a report of two cases","volume":"47","author":"Zisk, J.; Shore, J.M.; Rosoff, L.; Friedman, N.B.","year":"1960","unstructured":"Zisk, J., Shore, J. M., Rosoff, L., and Friedman, N. B. (1960). Regional enteritis complicated by adenocarcinoma of the ileum: a report of two cases. Surgery, 47, 970-974.","journal-title":"Surgery"},{"key":"ref_25","unstructured":"ADDENDUM carcinoma developing in a defunctioned loop of Since writing this report a further case has been jejunum in a man of 32 who had had symptoms of published (Tyers, Steiger, and Dudrick, 1969) of regional enteritis for 12 years.","article-title":"ADDENDUM carcinoma developing in a defunctioned loop of Since writing this report a further case has been jejunum in a man of 32 who had had symptoms of published (Tyers, Steiger, and Dudrick, 1969) of regional enteritis for 12 years"},{"key":"ref_26","unstructured":"The October 1969 Issue","article-title":"The October 1969 Issue"},{"key":"ref_27","unstructured":"THE OCTOBER 1969 ISSUE CONTAINS THE FOLLOWING PAPERS","article-title":"THE OCTOBER 1969 ISSUE CONTAINS THE FOLLOWING PAPERS"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.10.11.924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:40:28Z","timestamp":1765608028000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.10.11.924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,11]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1969,11,1]]},"published-print":{"date-parts":[[1969,11]]}},"alternative-id":["10.1136\/gut.10.11.924"],"URL":"https:\/\/doi.org\/10.1136\/gut.10.11.924","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1969,11]]}}}