{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:33:04Z","timestamp":1791286384646,"version":"4.1.0"},"reference-count":29,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1969,12]]},"abstract":"<jats:p>The gastrointestinal abnormalities encountered in 125 patients with the Ehlers-Danlos syndrome have been described. Spontaneous perforation of the intestine and massive gastrointestinal haemorrhage are uncommon but potentially lethal complications of the Ehlers-Danlos syndrome. Less dangerous abnormalities, such `as external hernia, hiatus hernia, eventration of the diaphragm, intestinal diverticula, and rectal prolapse were all encountered in patients in the series. Abdominal surgery in affected patients may be made difficult by fragility of tissues and a bleeding tendency. In the postoperative period, tearing out of sutures and wound dehiscence may occur.<\/jats:p>","DOI":"10.1136\/gut.10.12.1004","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1004-1008","source":"Crossref","is-referenced-by-count":114,"title":["Gastrointestinal complications of the Ehlers-Danlos syndrome"],"prefix":"10.1136","volume":"10","author":[{"given":"Peter H.","family":"Beighton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Lamont","family":"Murdoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Votteler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1969,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/bjs.1800540107","article-title":"Ehlers-Danlos syndrome causing intestinal perforation","volume":"54","author":"Aldridge, R.T.","year":"1967","unstructured":"Aldridge, R. T. (1967). Ehlers-Danlos syndrome causing intestinal perforation. Brit. J. Surg., 54, 22-25.","journal-title":"Brit. J. Surg"},{"key":"ref_2","first-page":"971","article-title":"Incidences haemorragiques et viscerales de la maladie d'EhlersDanlos","volume":"116","author":"Andre, R.; Duhamel, G.; Vergos, D.; Lavallee, R.","year":"1965","unstructured":"Andre, R., Duhamel, G., Vergos, D., and Lavallee, R. (1965). Incidences haemorragiques et viscerales de la maladie d'EhlersDanlos. Bull. Soc. med. H6p. Paris, 116, 971-976.","journal-title":"Bull. Soc. med. H6p. Paris"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1136\/bmj.3.5564.558-b","article-title":"EhlersDanlos syndrome","volume":"3","author":"Bannerman, R.M.; Graf, C.J.; Upson, J.F.","year":"1967","unstructured":"Bannerman, R. M., Graf, C. J., and Upson, J. F. (1967). EhlersDanlos syndrome. Brit. med. J., 3, 558-559.","journal-title":"Brit. med. J"},{"key":"ref_4","first-page":"656","article-title":"Lethal complications of the Ehlers-Danlos syndrome","volume":"3","author":"Beighton, P.","year":"1968","unstructured":"Beighton, P. (1968). Lethal complications of the Ehlers-Danlos syndrome. Ibid, 3, 656-659.","journal-title":"Ibid"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/bjs.1800560404","article-title":"Surgical aspects of the Ehlers-Danlos syndrome","volume":"56","author":"Beighton, P.; Horan, F.T.","year":"1969","unstructured":"Beighton, P. and Horan, F. T. (1969). Surgical aspects of the Ehlers-Danlos syndrome. Brit. J. Surg., 56, 255-259.","journal-title":"Brit. J. Surg"},{"key":"ref_6","article-title":"The Ehlers-Danlos syndrome","author":"Beighton, P.; Horan, F.T.; Horan, F.T.","year":"1970","unstructured":"Beighton, P. and Horan, F. T. and Horan, F. T. (1970). The Ehlers-Danlos syndrome. London, Heinemann. In press."},{"key":"ref_7","first-page":"413","article-title":"Contribution a l'etude de l'tiologie de la hernie hiatale et de la diverticulose du tube digestif: un cas de maladie d'Ehlers-Danlos associee a une hernie hiatale, un diverticule de l'estomac, un diverticule duodenal, une diverticulose colique et un anemie sideropenique","volume":"41","author":"Brombart, M.; Coupatez, G.; Laurent, Y.","year":"1952","unstructured":"Brombart, M., Coupatez, G., and Laurent, Y. (1952). Contribution a l'etude de l'tiologie de la hernie hiatale et de la diverticulose du tube digestif: un cas de maladie d'Ehlers-Danlos associee a une hernie hiatale, un diverticule de l'estomac, un diverticule duodenal, une diverticulose colique et un anemie sideropenique. Arch. Mal. Appar. dig., 41, 413-420.","journal-title":"Arch. Mal. Appar. dig"},{"key":"ref_8","first-page":"1463","article-title":"Un cas de maladie d'Ehlers-Danlos","volume":"52","author":"Dreyfus, G.; Weill, J.; Martineau, J.; Mathivat, A.","year":"1936","unstructured":"Dreyfus, G., Weill, J., Martineau, J., and Mathivat, A. (1936). Un cas de maladie d'Ehlers-Danlos. Bull. Soc. mid. Hop., Paris, 52, 1463-1469.","journal-title":"Bull. Soc. mid. Hop., Paris"},{"key":"ref_9","article-title":"Personal communication","author":"Epstein, C.J.","year":"1969","unstructured":"Epstein, C. J. (1969). Personal communication."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/0002-9343(62)90044-X","article-title":"The Ehiers-Danlos syndrome and neurofibromatosis in a kindred of mixed derivation, with special emphasis on hemostasis in the Ehlers-Danlos syndrome","volume":"32","author":"Goodman, R.M.; Levitsky, J.M.; Friedman, I.A.","year":"1962","unstructured":"Goodman, R. M., Levitsky, J. M., and Friedman, I. A. (1962). The Ehiers-Danlos syndrome and neurofibromatosis in a kindred of mixed derivation, with special emphasis on hemostasis in the Ehlers-Danlos syndrome. Amer. J. Med., 32, 976-983.","journal-title":"Amer. J. Med"},{"key":"ref_11","first-page":"75","article-title":"Haemorrhage into the upper part of the gastro-intestinal tract in three patients with heritable disorders of connective tissue","volume":"16","author":"Grant, A.K.; Aldor, T.A.M.","year":"1967","unstructured":"Grant, A. K. and Aldor, T. A. M. (1967). Haemorrhage into the upper part of the gastro-intestinal tract in three patients with heritable disorders of connective tissue. Aust. Ann. Med., 16, 75-79.","journal-title":"Aust. Ann. Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/0002-9343(66)90224-5","article-title":"Ehlers-Danlos syndrome complicated by acute haemorrhagic sigmoid diverticulitis with unusual Mitral valve abnormality","volume":"41","author":"Green, G.J.; Schuman, B.M.; Barron, J.","year":"1966","unstructured":"Green, G. J., Schuman, B. M., and Barron, J. (1966). Ehlers-Danlos syndrome complicated by acute haemorrhagic sigmoid diverticulitis with unusual Mitral valve abnormality. Amer. J. Med., 41, 622-625.","journal-title":"Amer. J. Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/archderm.1958.01560120052008","article-title":"Ehlers-Danlos syndrome","volume":"78","author":"Husebye, K.C.; Getz, K.","year":"1958","unstructured":"Husebye, K. C., and Getz, K. (1958). Ehlers-Danlos syndrome. Arch. Derm., 78, 732-739.","journal-title":"Arch. Derm"},{"key":"ref_14","first-page":"460","article-title":"Ehlers-Danlos syndrome: report of a case with onset at age 29","volume":"76","author":"Jacobs, P.H.","year":"1957","unstructured":"Jacobs, P. H. (1957). Ehlers-Danlos syndrome: report of a case with onset at age 29. Ibid, 76, 460-462.","journal-title":"Ibid"},{"key":"ref_15","author":"Kashiwagi, H.; Riddle, J.M.; Abraham, J.P.; Frame, B.","year":"1965","unstructured":"Kashiwagi, H., Riddle, J. M., Abraham, J. P., and Frame, B. (1965)."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1148\/65.3.352","article-title":"Ehlers-Danlos syndrome with ectopic bone formation","volume":"65","author":"Katz, I.; Steiner, K.","year":"1955","unstructured":"Katz, I., and Steiner, K. (1955). Ehlers-Danlos syndrome with ectopic bone formation. Radiology, 65, 352-360.","journal-title":"Radiology"},{"key":"ref_17","first-page":"232","article-title":"Cutis hyperelastica, the Ehlers-Danlos syndrome","volume":"84","author":"Lapayowker, M.S.","year":"1960","unstructured":"Lapayowker, M. S. (1960). Cutis hyperelastica, the Ehlers-Danlos syndrome. Amer. J. Roentgenol., 84, 232-234.","journal-title":"Amer. J. Roentgenol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"388","DOI":"10.7326\/0003-4819-53-2-388","article-title":"Plasma thromboplastin component deficiency in the Ehlers-Danlos syndrome","volume":"53","author":"Lisker, R.; Nogueron, A.; Sanchez-Medal, L.","year":"1960","unstructured":"Lisker, R., Nogueron, A., and Sanchez-Medal, L. (1960). Plasma thromboplastin component deficiency in the Ehlers-Danlos syndrome. Ann. intern. Med., 53, 388-395.","journal-title":"Ann. intern. Med"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1001\/jama.1965.03090220067024","article-title":"Ehlers-Danlos syndrome and \"congenital\" arteriovenous fistulae","volume":"194","author":"Lynch, H.T.; Larsen, A.L.; Wilson, R.; Magnuson, C.L.","year":"1965","unstructured":"Lynch, H. T., Larsen, A. L., Wilson, R., and Magnuson, C. L. (1965). Ehlers-Danlos syndrome and \"congenital\" arteriovenous fistulae. J. Amer. med. Ass., 194, 1011-1014.","journal-title":"J. Amer. med. Ass"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJM196412172712508","article-title":"Mortality in Ehlers-Danlos syndrome due to spontaneous rupture of large arteries","volume":"271","author":"McFarland, W.; Fuller, D.E.","year":"1964","unstructured":"McFarland, W., and Fuller, D. E. (1964). Mortality in Ehlers-Danlos syndrome due to spontaneous rupture of large arteries. New Engl. J. Med., 271, 1309-1312.","journal-title":"New Engl. J. Med"},{"key":"ref_21","first-page":"179","article-title":"Heritable Disorders of Connective Tissue","author":"McKusick, V.A.","year":"1966","unstructured":"McKusick, V. A. (1966). Heritable Disorders of Connective Tissue, pp. 179-229. C. V. Mosby, St. Louis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/003693306000500607","article-title":"Ehlers-Danlos syndrome with a report of a fatal case","volume":"5","author":"Mories, A.","year":"1960","unstructured":"Mories, A. (1960). Ehlers-Danlos syndrome with a report of a fatal case. Scot. med. J., 5, 269-272.","journal-title":"Scot. med. J"},{"key":"ref_23","article-title":"M6ga-organes (oesophage, trachee, colon) syndromes de Mickuliez et d'Ehlers-Danlos chez une heredo-syphilitique","author":"Mounier-Kuhn, P.; Meyer, L.","year":"1943","unstructured":"Mounier-Kuhn, P., and Meyer, L. (1943). M6ga-organes (oesophage, trachee, colon) syndromes de Mickuliez et d'Ehlers-Danlos chez une heredo-syphilitique. Bull. Soc. med. Hop. Lyon.","journal-title":"Bull. Soc. med. Hop. Lyon"},{"key":"ref_24","first-page":"120","article-title":"Erster Fall von \"Syndrome d'EhlersDanlos\" in Japan","volume":"60","author":"Ota, M.; Yasuda, T.","year":"1941","unstructured":"Ota, M., and Yasuda, T. (1941). Erster Fall von \"Syndrome d'EhlersDanlos\" in Japan. Zbl. Haut. Geschl. -kr., 60, 120.","journal-title":"Zbl. Haut. Geschl. -kr"},{"key":"ref_25","first-page":"27","article-title":"Dermatorrhexis: a case report-the so-called Ehlers-Danlos syndrome. Virginia mned","volume":"81","author":"Packer, B.D.; Blades, J.F.","year":"1954","unstructured":"Packer, B. D., and Blades, J. F. (1954). Dermatorrhexis: a case report-the so-called Ehlers-Danlos syndrome. Virginia mned. Mon., 81, 27-30.","journal-title":"Mon"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1080\/00325481.1966.11696024","article-title":"Ehlers-Danlos syndrome. Incidence in three generations of a kindred","volume":"40","author":"Papp, J.P.; Paley, R.G.","year":"1966","unstructured":"Papp, J. P., and Paley, R. G. (1966). Ehlers-Danlos syndrome. Incidence in three generations of a kindred. Postgrad. Med., 40, 586-592.","journal-title":"Postgrad. Med"},{"key":"ref_27","first-page":"245","article-title":"Das Ehlers-Danlos syndrome","volume":"6","author":"Rossi, E.; Angst, H.","year":"1951","unstructured":"Rossi, E., and Angst, H. (1951). Das Ehlers-Danlos syndrome. Helv. paediat. Acta, 6, 245-254.","journal-title":"Helv. paediat. Acta"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1212\/WNL.14.2.125","article-title":"Ehlers-Danlos syndrome associated with multiple intracranial aneurysms","volume":"14","author":"Rubinstein, M.K.; Cohen, N.H.","year":"1964","unstructured":"Rubinstein, M. K., and Cohen, N. H. (1964). Ehlers-Danlos syndrome associated with multiple intracranial aneurysms. Neurology (Minneap.), 14, 125-132.","journal-title":"Neurology (Minneap.)"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1001\/archderm.1967.01610050062009","article-title":"Ehlers-Danlos syndrome with a hypoplastic kidney, bladder diverticulum and diaphragmatic hernia","volume":"96","author":"Zalis, E.G.; Roberts, D.C.","year":"1967","unstructured":"Zalis, E. G., and Roberts, D. C. (1967). Ehlers-Danlos syndrome with a hypoplastic kidney, bladder diverticulum and diaphragmatic hernia. Arch. Derm., 96, 540-544.","journal-title":"Arch. Derm"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.10.12.1004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:53:27Z","timestamp":1765623207000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.10.12.1004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,12]]},"references-count":29,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1969,12,1]]},"published-print":{"date-parts":[[1969,12]]}},"alternative-id":["10.1136\/gut.10.12.1004"],"URL":"https:\/\/doi.org\/10.1136\/gut.10.12.1004","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,12]]}}}