{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:41:24Z","timestamp":1791031284610,"version":"4.1.0"},"reference-count":31,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1969,9]]},"abstract":"<jats:p>The effect of desferrioxamine is examined in more than 100 patients with liver disease, including haemochromatosis, using the differential ferrioxamine test.<\/jats:p>\n                  <jats:p>The procedure gives a reasonably accurate estimate of the size of the iron stores, as determined by multiple venesection, in patients with idiopathic haemochromatosis. Since desferrioxamine is not specific for storage iron, unequivocally abnormal results are not obtained unless the iron load exceeds about 2\u00b73 g.<\/jats:p>\n                  <jats:p>In other forms of liver disease the effect of desferrioxamine is generally increased compared with that in controls. The results show no correlation with the serum iron level or the degree of hepatic siderosis. High values are usual in the presence of jaundice and overlap the range found in untreated haemochromatosis, adding to other evidence that desferrioxamine can derive iron from a hyperchelatable source unrelated to the stores.<\/jats:p>\n                  <jats:p>It is concluded that in liver diseases other than haemochromatosis the results of the test do not reliably reflect body storage iron content.<\/jats:p>","DOI":"10.1136\/gut.10.9.697","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"697-704","source":"Crossref","is-referenced-by-count":17,"title":["Differential ferrioxamide test in haemochromatosis and liver disease"],"prefix":"10.1136","volume":"10","author":[{"given":"Michael","family":"Barry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiseppe","family":"Cartei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Sherlock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1969,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.7326\/0003-4819-68-3-518","article-title":"Measurement of iron stores using deferoxamine","volume":"68","author":"Balcerzak, S.P.; Westerman, M.P.; W., Heinle E.; Taylor, F.H.","year":"1968","unstructured":"Balcerzak, S. P., Westerman, M. P., Heinle E. W., and Taylor, F. H. (1968). Measurement of iron stores using deferoxamine. Ann. intern. Med., 68, 518-525.","journal-title":"Ann. intern. Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0002-9343(66)90201-4","article-title":"Idiopathic hemochromatosis. A study of three families","volume":"40","author":"Balcerzak, S.P.; Westerman, M.P.; W., Heinle E.; Taylor, F.H.; Lee, R.E.; Doyle, A.P.","year":"1966","unstructured":"Balcerzak, S. P., Westerman, M. P., Heinle E. W., and Taylor, F. H., Lee, R. E., and Doyle, A. P. (1966). Idiopathic hemochromatosis. A study of three families. Amer. J. Med., 40, 857-873.","journal-title":"Amer. J. Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1136\/jcp.21.2.166","article-title":"D-termination of chelated iron in urine","volume":"21","author":"Barry, M.","year":"1968","unstructured":"Barry, M. (1968). D-termination of chelated iron in urine. J. clin. Path., 21, 166-168.","journal-title":"J. clin. Path"},{"key":"ref_4","first-page":"169","article-title":"Estimation of ferrioxamine in jaundiced urine","volume":"21","author":"Barry, M.; Cartei, G.C.","year":"1968","unstructured":"Barry, M. and Cartei, G. C. (1968). Estimation of ferrioxamine in jaundiced urine. Ibid., 21, 169-170.","journal-title":"Ibid"},{"key":"ref_5","first-page":"88","article-title":"Differential ferrioxamine test for measuring chelatable body iron","volume":"18","author":"Fielding, J.","year":"1965","unstructured":"Fielding, J. (1965). Differential ferrioxamine test for measuring chelatable body iron. Ibid., 18, 88-97.","journal-title":"Ibid"},{"key":"ref_6","first-page":"\"668","article-title":"Desferrioxamine chelatable body iron","volume":"20","author":"Fielding, J.","year":"1967","unstructured":"Fielding, J. (1967). Desferrioxamine chelatable body iron. Ibid., 20, 668-670, and Brunstrom, G. M. (1964). Estimation of ferrioxamine and desferrioxamine in urine. Ibid., 17, 395-398.","journal-title":"Ibid; Estimation of ferrioxamine and desferrioxamine in urine"},{"key":"ref_7","first-page":"402","article-title":"Storage iron depletion in male blood donors: its significance for iron status in women","volume":"21","author":"Karabus, C.D.; Brunstrom, G.M.","year":"1968","unstructured":"Karabus, C. D., and Brunstrom, G. M. (1968). Storage iron depletion in male blood donors: its significance for iron status in women. Ibid., 21, 402-405.","journal-title":"Ibid"},{"key":"ref_8","first-page":"9","article-title":"Iron deficiency without anaemia","volume":"2","author":"O'Shaughnessy, M.C.; Brunstrom, G.M.","year":"1965","unstructured":"O'Shaughnessy, M. C., and Brunstrom, G. M. (1965). Iron deficiency without anaemia. Lancet, 2, 9-12.","journal-title":"Lancet"},{"key":"ref_9","first-page":"159","article-title":"Differential ferrioxamine test in idiopathic haemochromatosis and transfusional haemosiderosis","volume":"19","author":"O'Shaughnessy, M.C.; Brunstrom, G.M.","year":"1966","unstructured":"O'Shaughnessy, M. C., and Brunstrom, G. M. (1966). Differential ferrioxamine test in idiopathic haemochromatosis and transfusional haemosiderosis. Ibid., 19, 159-164.","journal-title":"Ibid"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1152\/ajplegacy.1968.215.4.807","article-title":"Biliary iron excretion in normal and iron-loaded rats after desferrioxamine and CaDTPA","volume":"215","author":"Figueroa, W.G.; Thompson, J.H.","year":"1968","unstructured":"Figueroa, W. G., and Thompson, J. H. (1968). Biliary iron excretion in normal and iron-loaded rats after desferrioxamine and CaDTPA. Amer. J. Physiol., 215, 807-810.","journal-title":"Amer. J. Physiol"},{"key":"ref_11","author":"Hallberg, L.","year":"1964","unstructured":"Hallberg, L. (1964). In Iron Metabolism, An International Symposium. Edited by F. Gross. Springer, Berlin."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-0609.1965.tb01280.x","article-title":"The effect of desferrioxamine on iron metabolism in man","volume":"2","author":"Hallberg, L.; Hedenberg, L.","year":"1965","unstructured":"Hallberg, L. and Hedenberg, L. (1965a). The effect of desferrioxamine on iron metabolism in man. Scand. J. Haemat., 2, 67-79.","journal-title":"Scand. J. Haemat"},{"key":"ref_13","first-page":"277","article-title":"The effect of desferrioxamine on iron metabolism in man","volume":"2","author":"Hallberg, L.","year":"1965","unstructured":"Hallberg, L. (1965b). The effect of desferrioxamine on iron metabolism in man. II. Ibid., 2, 277-287.","journal-title":"II. Ibid"},{"key":"ref_14","first-page":"85","article-title":"Liver iron and desferrioxamineinduced urinary iron excretion","volume":"3","author":"Hallberg, L.; Weinfeld, A.","year":"1966","unstructured":"Hallberg, L., and Weinfeld, A. (1966). Liver iron and desferrioxamineinduced urinary iron excretion. Ibid., 3, 85-98.","journal-title":"Ibid"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0002-9343(68)90012-0","article-title":"Evaluation of storage iron by chelates","volume":"45","author":"Harker, L.A.; Funk, D.D.; Finch, C.A.","year":"1968","unstructured":"Harker, L. A., Funk, D. D., and Finch, C. A. (1968). Evaluation of storage iron by chelates. Amer. J. Med., 45, 105-115.","journal-title":"Amer. J. Med"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1172\/JCI103087","article-title":"The anemia of liver disease: observations on its mechanism","volume":"34","author":"Jandl, J.H.","year":"1955","unstructured":"Jandl, J. H. (1955). The anemia of liver disease: observations on its mechanism. J. clin. Invest., 34, 390-404.","journal-title":"J. clin. Invest"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/j.1365-2141.1967.tb08862.x","article-title":"Desferrioxamine chelatable iron in haemolytic, megaloblastic and sideroblastic anaemias","volume":"13","author":"Karabus, C.D.; Fielding, J.","year":"1967","unstructured":"Karabus, C. D., and Fielding, J. (1967). Desferrioxamine chelatable iron in haemolytic, megaloblastic and sideroblastic anaemias. Brit. J. Haemat., 13, 924-933.","journal-title":"Brit. J. Haemat"},{"key":"ref_18","first-page":"33","article-title":"The mechanism of anaemia in liver disease","volume":"34","author":"Kimber, C.; Deller, D.J.; Ibbotson, R.N.; Lander, H.","year":"1965","unstructured":"Kimber, C., Deller, D. J., Ibbotson, R. N., and Lander, H. (1965). The mechanism of anaemia in liver disease. Quart. J. Med., 34, 33-64.","journal-title":"Quart. J. Med"},{"key":"ref_19","first-page":"224","article-title":"Prediction of blood volume in normal human adults","volume":"51","author":"Nadler, S.B.; Hidalgo, J.U.; Bloch, T.","year":"1962","unstructured":"Nadler, S. B., Hidalgo, J. U., and Bloch, T. (1962). Prediction of blood volume in normal human adults. Surgery 51, 224-232.","journal-title":"Surgery"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1136\/jcp.19.4.364","article-title":"Iron chelation in haematomas at fracture sites","volume":"19","author":"C., O.'Shaughnessy M.; Brunstrom, G.M.; Fielding, J.","year":"1966","unstructured":"O'Shaughnessy. M. C., Brunstrom, G. M. and Fielding, J. (1966). Iron chelation in haematomas at fracture sites. J. clin. Path., 19, 364-367.","journal-title":"J. clin. Path"},{"key":"ref_21","first-page":"239","article-title":"Reduced red cell survival in jaundice and its relation to glutathione metabolism","volume":"24","author":"Pitcher, C.S.; Williams, R.","year":"1963","unstructured":"Pitcher, C. S., and Williams, R. (1963). Reduced red cell survival in jaundice and its relation to glutathione metabolism. Clin. Sci., 24, 239-252.","journal-title":"Clin. Sci"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1172\/JCI103312","article-title":"On the presence of ferritin in the peripheral blood of patients with hepatocellular disease","volume":"35","author":"Reissman, K.R.; Dietrich, M.R.","year":"1956","unstructured":"Reissman, K. R., and Dietrich, M. R. (1956). On the presence of ferritin in the peripheral blood of patients with hepatocellular disease. J. clin. Invest., 35, 588-595.","journal-title":"J. clin. 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Gastro-ent"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/pgmj.43.505.708","article-title":"Siderosis, haemolysis, or hepatonecrosis in increasing post-desferrioxamine sideruria in acute viral hepatitis?","volume":"43","author":"Scuro, L.A.; Dobrilla, G.","year":"1967","unstructured":"Scuro, L. A., and Dobrilla, G. (1967). Siderosis, haemolysis, or hepatonecrosis in increasing post-desferrioxamine sideruria in acute viral hepatitis? Postgrad. med. J., 43, 708-71 1.","journal-title":"Postgrad. med. J"},{"key":"ref_26","first-page":"133","article-title":"Assessment of body-iron stores in cirrhosis and haemochromatosis with the differential ferrioxamine test","volume":"1","author":"Smith, P.M.; Studley, F.; Williams, R.","year":"1967","unstructured":"Smith, P. M., Studley, F., and Williams, R. (1967). Assessment of body-iron stores in cirrhosis and haemochromatosis with the differential ferrioxamine test. 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The differential ferrioxamine test in rheumatoid disease, neoplastic, and other haematological disorders. Brit. J. Haemat., 14, 5-11.","journal-title":"Brit. J. Haemat"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1136\/jcp.18.1.98","article-title":"Method for the automatic determination of serum iron","volume":"18","author":"Young, D.S.; Hicks, J.M.","year":"1965","unstructured":"Young, D. S., and Hicks, J. M. (1965). Method for the automatic determination of serum iron. J. clin. Path., 18, 98-102.","journal-title":"J. clin. Path"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.10.9.697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:10:06Z","timestamp":1765609806000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.10.9.697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,9]]},"references-count":31,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1969,9,1]]},"published-print":{"date-parts":[[1969,9]]}},"alternative-id":["10.1136\/gut.10.9.697"],"URL":"https:\/\/doi.org\/10.1136\/gut.10.9.697","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,9]]}}}