{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:22:47Z","timestamp":1765081367276,"version":"3.46.0"},"reference-count":23,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1970,6]]},"abstract":"<jats:p>Jejunal biopsy has been carried out in 19 relatives of patients with dermatitis herpetiformis and stereomicroscopic abnormalities have been found in seven. The majority of the relatives in whom these abnormalities were found had no bowel symptoms: one had the rash of dermatitis herpetiformis. All but one of the propositi of the relatives in whom were found small intestinal mucosal abnormalities themselves had the coeliac syndrome. It is concluded that a genetic factor is involved in the production of the enteropathy of dermatitis herpetiformis as in other forms of the coeliac syndrome.<\/jats:p>","DOI":"10.1136\/gut.11.6.493","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"493-497","source":"Crossref","is-referenced-by-count":27,"title":["Small intestinal mucosal abnormalities in relatives of patients with dermatitis herpetiformis"],"prefix":"10.1136","volume":"11","author":[{"given":"Janet","family":"Marks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Birkett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Shuster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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Alr. med"},{"key":"ref_3","first-page":"1223","article-title":"Coeliac sprue and the sprue-like lesion of dermatitis herpetiformisseparate or related entities?","volume":"54","author":"Brow, J.R.; Parker, F.; Rubin, C.E.","year":"1968","unstructured":"Brow, J. R., Parker, F., and Rubin, C. E. (1968). Coeliac sprue and the sprue-like lesion of dermatitis herpetiformisseparate or related entities? Gastroenterology, 54, 1223-9.","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3109\/00365526809180128","article-title":"Jejunal biopsy findings in healthy young men","volume":"3","author":"Burhol, P.G.; Myren, J.","year":"1968","unstructured":"Burhol, P. G., and Myren, J. (1968). Jejunal biopsy findings in healthy young men. Scand. J. Gastroent., 3, 346-350.","journal-title":"Scand. J. Gastroent"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1469-1809.1959.tb01470.x","article-title":"The inheritance of coeliac disease","volume":"23","author":"Carter, C.; Sheldon, W.; Walker, C.","year":"1959","unstructured":"Carter, C., Sheldon, W., and Walker, C. (1959). The inheritance of coeliac disease. Ann. hum. Genet., 23, 266-278.","journal-title":"Ann. hum. Genet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/BF02231100","article-title":"Intraluminal biopsy of the small-intestine","volume":"2","author":"Crosby, W.H.; Kugler, H.W.","year":"1957","unstructured":"Crosby, W. H., and Kugler, H. W. (1957). Intraluminal biopsy of the small-intestine. Amer. J. dig. Dis., 2, 236-241.","journal-title":"Amer. J. dig. 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Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/jmg.6.2.129","article-title":"Inheritance of coeliac disease","volume":"6","author":"McCrae, W.M.","year":"1969","unstructured":"McCrae, W. M. (1969). Inheritance of coeliac disease. J. Med. Genet., 6, 129-131.","journal-title":"J. Med. Genet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/gut.11.4.281","article-title":"Small-intestinal mucosal abnormalities in various skin diseases-fact or fancy?","volume":"11","author":"Marks, J.; Shuster, S.","year":"1970","unstructured":"Marks, J., and Shuster, S. (1970). Small-intestinal mucosal abnormalities in various skin diseases-fact or fancy? 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(Lond.)"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1136\/bmj.1.5591.552","article-title":"Small-bowel abnormalities in dermatitis herpetiformis","volume":"1","author":"Marks, R.; Whittle, M.W.; Beard, R.J.; Robertson, W.B.; Gold, S.C.","year":"1968","unstructured":"Marks, R., Whittle, M. W., Beard, R. J., Robertson, W. B., and Gold, S. C. (1968). Small-bowel abnormalities in dermatitis herpetiformis. Brit. med. J., 1, 552-555.","journal-title":"Brit. med. J"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/ajcn\/18.2.134","article-title":"A preliminary study of factors affecting blood lipid levels in three groups of Yemenite Jews","volume":"18","author":"Parkins, R.A.; Eidelman, S.; Perrin, E.B.; Rubin, C.E.","year":"1966","unstructured":"Parkins, R. A., Eidelman, S., Perrin, E. B., and Rubin, C. E. (1966). A preliminary study of factors affecting blood lipid levels in three groups of Yemenite Jews. Amer. J. clin. 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Comparison of jejunal mucosa in post-gastrectomy states, idiopathic steatorrhoea, and controls using the dissecting microscope and conventional histological methods. Gut, 5, 553-562.","journal-title":"Gut"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0140-6736(68)90181-5","article-title":"Coeliac syndrome in dermatitis herpetiformis","volume":"1","author":"Shuster, S.; Watson, A.J.; Marks, J.","year":"1968","unstructured":"Shuster, S., Watson, A. J., and Marks, J. (1968). Coeliac syndrome in dermatitis herpetiformis. Lancet, 1, 1101-1106.","journal-title":"Lancet"},{"key":"ref_22","first-page":"176","article-title":"The diagnosis of dermatitis herpetiformis","volume":"52","author":"Smith, E.L.","year":"1966","unstructured":"Smith, E. L. (1966). The diagnosis of dermatitis herpetiformis. Trans. St. John's Hosp. derm. Soc. (Lond.), 52, 176-196.","journal-title":"Trans. St. John's Hosp. derm. Soc. 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