{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:57:54Z","timestamp":1772762274509,"version":"3.50.1"},"reference-count":29,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1971,10]]},"abstract":"<jats:p>A 44-year-old woman is described with an endocrine tumour arising in the kidney. There were associated abnormalities of small intestinal morphology, motility, and absorptive function. These abnormalities reversed on removal of the tumour. Detailed studies showed that the tumour contained, and was secreting, glucagon. It is postulated that the intestinal abnormalities may have resulted from glucagon itself or another, as yet unidentified, hormone.<\/jats:p>","DOI":"10.1136\/gut.12.10.773","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"773-782","source":"Crossref","is-referenced-by-count":303,"title":["Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function"],"prefix":"10.1136","volume":"12","author":[{"given":"M. H.","family":"Gleeson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Polak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. H.","family":"Dowling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1971,10,1]]},"reference":[{"key":"ref_1","series-title":"vitro Procedures with Radioisotopes in Medicine. (Proceedings of International Atomic Energy Authority Symposium","first-page":"491","article-title":"The attainment of high sensitivity and precision in radioimmunoassay techniques as exemplified in a simple assay of serum insulin","author":"Albano, J.; Elkins, R.P.","year":"1970","unstructured":"Albano, J., and Elkins, R. P. (1970). The attainment of high sensitivity and precision in radioimmunoassay techniques as exemplified in a simple assay of serum insulin. In vitro Procedures with Radioisotopes in Medicine. (Proceedings of International Atomic Energy Authority Symposium, Vienna, 1969). pp. 491-513. I.A.E.A., Vienna."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/bjs.18004619821","article-title":"Intestinal hypertrophy following partial resection of the small bowel in the rat","volume":"46","author":"Booth, C.C.; Evans, K.T.; Menzies, T.; Street, D.F.","year":"1959","unstructured":"Booth, C. C., Evans, K. T., Menzies, T., and Street, D. F. (1959). Intestinal hypertrophy following partial resection of the small bowel in the rat. Brit. J. Surg., 46, 403-410.","journal-title":"Brit. J. Surg"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1084\/jem.102.1.49","article-title":"Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to study of the hyperimmune rabbit","volume":"102","author":"Coons, A.H.; Leduc, E.H.; andConnolly, J.M.","year":"1955","unstructured":"Coons, A. H., Leduc, E.H.,andConnolly, J. M. (1955). Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to study of the hyperimmune rabbit. J. exp. Med., 102, 49-60.","journal-title":"J. exp. Med"},{"key":"ref_4","first-page":"657663","article-title":"A method for the determination of urinary indoxyl sulphate (indican)","volume":"7","author":"Curzon, G.; Walsh, J.","year":"1962","unstructured":"Curzon, G., and Walsh, J. (1962). A method for the determination of urinary indoxyl sulphate (indican). Clin. chim. Acta, 7, 657663.","journal-title":"Clin. chim. Acta"},{"key":"ref_5","first-page":"139","article-title":"Structural and functional changes following small intestinal resection in the rat","volume":"32","author":"Dowling, R.H.; Booth, C.C.","year":"1967","unstructured":"Dowling, R. H., and Booth, C. C. (1967). Structural and functional changes following small intestinal resection in the rat. Clin. Sci., 32, 139-149.","journal-title":"Clin. Sci"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0016-5085(70)80067-1","article-title":"Influence of glucagon on pancreatic exocrine secretion in man","volume":"58","author":"Dyck, W.P.; Texter, Jr., E.C.; Lasater, J.M.; Hightower, Jr, N.C.","year":"1970","unstructured":"Dyck, W. P., Texter, E. C., Jr., Lasater, J. M., and Hightower, N. C., Jr. (1970). Influence of glucagon on pancreatic exocrine secretion in man. Gastroenterology, 58, 532-539.","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1055\/s-0028-1112452","article-title":"Metastasierendes Inselzelikarzinom vom A-Zelltyp bei einem Fall von Pemphigus foliaceus mit Diabetes renalis","volume":"85","author":"Gdssner, W.; Korting, G.W.","year":"1960","unstructured":"Gdssner, W., and Korting, G. W. (1960). Metastasierendes Inselzelikarzinom vom A-Zelltyp bei einem Fall von Pemphigus foliaceus mit Diabetes renalis. Dtsch. med. Wschr., 85, 434-437.","journal-title":"Dtsch. med. Wschr"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1172\/JCI100862","article-title":"Gastro-intestinal studies. VII. The excretion of xylose in pernicious anemia","volume":"16","author":"Helmer, 0. M.; Fouts, P. J","year":"1937","unstructured":"Helmer, 0. M., and Fouts, P. J. (1937). Gastro-intestinal studies. VII. The excretion of xylose in pernicious anemia. J. clin. Invest., 16, 343-349.","journal-title":"J. clin. Invest"},{"key":"ref_9","first-page":"820","article-title":"Impairment of fat absorption by altered intestinal motility","volume":"48","author":"Hershenson, L.M.","year":"1965","unstructured":"Hershenson, L. M. (1965). Impairment of fat absorption by altered intestinal motility. (Abstr.). Gastroenterology, 48, 820-821.","journal-title":"(Abstr.). Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0021-9258(18)57092-7","article-title":"Rapid method for the determination of fat in feces","volume":"177","author":"van de Kamer, J.H.; ten Bokkel Huinink, H.; Weyers, H.A.","year":"1949","unstructured":"van de Kamer, J. H., ten Bokkel Huinink, H., and Weyers, H. A. (1949). Rapid method for the determination of fat in feces. J. biol. Chem., 177, 347-355.","journal-title":"J. biol. Chem"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0016-5085(19)34266-0","article-title":"Inhibition of intestinal motility in man by glucagon given intraportally","volume":"53","author":"Kock, N.G.; Darle, N.; Dotevall, G.","year":"1967","unstructured":"Kock, N. G., Darle, N., and Dotevall, G. (1967). Inhibition of intestinal motility in man by glucagon given intraportally. Gastroenterology, 53, 88-92.","journal-title":"Gastroenterology"},{"key":"ref_12","first-page":"373379","article-title":"Hemodynamic responses to glucagon: an experimental study of central, visceral and peripheral effects","volume":"171","author":"Kock, N.G.; Tibblin, S.; Schenk, Jr, W.G.","year":"1970","unstructured":"Kock, N. G., Tibblin, S., and Schenk, W. G., Jr. (1970). Hemodynamic responses to glucagon: an experimental study of central, visceral and peripheral effects. Ann. Surg., 171, 373379.","journal-title":"Ann. Surg"},{"key":"ref_13","first-page":"1311","article-title":"Correlation of radiological and histological findings in idiopathicsteatorrhoea","volume":"1","author":"Laws, J.W.; Shawdon, H.; Booth, C.C.; Stewart, J.S.","year":"1963","unstructured":"Laws, J. W., Shawdon, H., Booth, C. C., and Stewart, J. S. (1963). Correlation of radiological and histological findings in idiopathicsteatorrhoea. Brit. med. J., 1, 1311-1314.","journal-title":"Brit. med. J"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1083\/jcb.7.4.667","article-title":"Cellular proliferation of intestinal epithelia in the rat two months after partial resection of the ileum","volume":"7","author":"Loran, M.R.; Althausen, T.L.","year":"1960","unstructured":"Loran, M. R., and Althausen, T. L. (1960). Cellular proliferation of intestinal epithelia in the rat two months after partial resection of the ileum. J. biophys. biochem. Cytol., 7, 667-672.","journal-title":"J. biophys. biochem. Cytol"},{"key":"ref_15","first-page":"127","volume-title":"Gastrointestinal Radiation Injury; Excerpta Medica Foundation, Amsterdam.","author":"Loran, M.R.; Carbone, J.V.","year":"1968","unstructured":"Loran, M. R., and Carbone, J. V. (1968). In Gastrointestinal Radiation Injury, edited by M. F. Sullivan, pp. 127-139. Excerpta Medica Foundation, Amsterdam."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1083\/jcb.19.2.285","article-title":"Population dynamics of intestinal epithelia in the rat two months after partial resection of the ileum","volume":"19","author":"Loran, M.R.; Crocker, T.T.","year":"1963","unstructured":"Loran, M. R., and Crocker, T. T. (1963). Population dynamics of intestinal epithelia in the rat two months after partial resection of the ileum. J. Cell Biol., 19, 285-291.","journal-title":"J. Cell Biol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1056\/NEJM196606232742503","article-title":"A glucagon-secreting alpha-cell carcinoma of the pancreas","volume":"274","author":"McGavran, M.H.; Unger, R.H.; Recant, L.; Polk, H.C.; Kilo, C.; Levin, M.E.","year":"1966","unstructured":"McGavran, M. H., Unger, R. H., Recant, L., Polk, H. C., Kilo, C., and Levin, M. E. (1966). A glucagon-secreting alpha-cell carcinoma of the pancreas. New Engl. J. Med., 274, 1408-1413.","journal-title":"New Engl. J. Med"},{"key":"ref_18","first-page":"1056","article-title":"The production of indole by bacteria in vitro","volume":"10","author":"Neale, G.; Lambert, R.A.; Gorbach, S.","year":"1969","unstructured":"Neale, G., Lambert, R. A., and Gorbach, S. (1969). The production of indole by bacteria in vitro. Gut, 10, 1056-1057. (Abstr.)","journal-title":"Gut"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/17.5.303","article-title":"The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept","volume":"17","author":"Pearse, A.G.E.","year":"1969","unstructured":"Pearse, A. G. E. (1969). The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J. Histochem. Cytochem., 17, 303-313.","journal-title":"J. Histochem. Cytochem"},{"key":"ref_20","article-title":"Unpublished observations","author":"Polak, J.M.","year":"1971","unstructured":"Polak, J. M. (1971). Unpublished observations."},{"key":"ref_21","author":"Polak, J.M.; Bloom, S.; Coulling, I.; Pearse, A.G.E.","year":"1971","unstructured":"Polak, J. M., Bloom, S., Coulling, I., and Pearse, A. G. E. (1971)."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/gut.12.4.319","article-title":"Tbe G celis in pernicious anaemia","volume":"12","author":"Polak, J.M.; Coulling, I.; Doe, W.; Pearse, A.G.E.","year":"1971","unstructured":"Polak, J. M., Coulling, I., Doe, W., and Pearse, A. G. E. (1971), Tbe G celis in pernicious anaemia. Gut, 12, 319-323.","journal-title":"Gut"},{"key":"ref_23","first-page":"93","article-title":"The melanocyte: Its cytochemical and immunological relationship to cells of the endocrine polypeptide (APUD) series","volume":"4","author":"Rost, F.W.D.; Polak, J.M.; Pearse, A.G.E.","year":"1969","unstructured":"Rost, F. W. D., Polak, J. M., and Pearse, A. G. E. (1969). The melanocyte: Its cytochemical and immunological relationship to cells of the endocrine polypeptide (APUD) series. Virchows Arch. (Zellpath.], 4, 93-101.","journal-title":"Virchows Arch. (Zellpath.]"},{"key":"ref_24","first-page":"860","article-title":"Intrinsicfactor studies. II. The effect ofgastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B13","volume":"42","author":"Schilling, R.F.","year":"1953","unstructured":"Schilling, R. F. (1953). Intrinsicfactor studies. II. The effect ofgastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B13. J. Lab. clin. Med., 42, 860-866.","journal-title":"J. Lab. clin. Med"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00309872","article-title":"Differential staining of catecholamines, 5-hydroxytryptamine and related compounds in aldehyde-fixed tissues","volume":"17","author":"Solcia, E.; Sampietro, R.; Capella, C.","year":"1969","unstructured":"Solcia, E., Sampietro, R., and Capella, C. (1969). Differential staining of catecholamines, 5-hydroxytryptamine and related compounds in aldehyde-fixed tissues. Histochemie, 17, 273-283.","journal-title":"Histochemie"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0009-8981(66)90061-1","article-title":"Demonstration of protein-losing gastroenteropathy: the disappearance rate '1Cr from plasma and the binding of \"'Cr to different serum proteins","volume":"14","author":"van Tongeren, J.H.M.; Majoor, C.L.H.","year":"1966","unstructured":"van Tongeren, J. H. M., and Majoor, C. L. H. (1966). Demonstration of protein-losing gastroenteropathy: the disappearance rate '1Cr from plasma and the binding of \"'Cr to different serum proteins. Clin. chim. Acta, 14, 31-41.","journal-title":"Clin. chim. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1210\/jcem-24-9-823","article-title":"Identification of insulin and glucagon in a bronchogenic metastasis","volume":"24","author":"Unger, R.H.; Lochner, J.de V.; Eisentraut, A.M.","year":"1964","unstructured":"Unger, R. H., Lochner, J. de V., and Eisentraut, A. M. (1964). Identification of insulin and glucagon in a bronchogenic metastasis. J. clin. Endocr., 24, 823-831.","journal-title":"J. clin. Endocr"},{"key":"ref_28","first-page":"299","article-title":"Hypersecretion of insulin, glucagon and gastrin in a kindred with multiple adenomatosis","volume":"17","author":"Vance, J.E.; Kitabchi, A.E.; Buchanan, K.D.; Stoll, R.W.; Hollander, D.; Wood, F.C.","year":"1968","unstructured":"Vance, J. E., Kitabchi, A. E., Buchanan, K. D., Stoll, R. W., Hollander, D., and Wood, F. C. (1968). Hypersecretion of insulin, glucagon and gastrin in a kindred with multiple adenomatosis. (Abstr.) Diabetes, 17, 299.","journal-title":"(Abstr.) Diabetes"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2337\/diab.15.10.709","article-title":"Pancreatic A-cell tumor associated with severe diabetes mellitus","volume":"15","author":"Yoshinaga, T.; Okuno, G.; Shinji, Y.; Tsujii, T.; Nishikawa, M.","year":"1966","unstructured":"Yoshinaga, T., Okuno, G., Shinji, Y., Tsujii, T., and Nishikawa, M. (1966). Pancreatic A-cell tumor associated with severe diabetes mellitus. Diabetes, 15, 709-713.","journal-title":"Diabetes"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.12.10.773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:27:43Z","timestamp":1765639663000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.12.10.773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,10]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1971,10,1]]},"published-print":{"date-parts":[[1971,10]]}},"alternative-id":["10.1136\/gut.12.10.773"],"URL":"https:\/\/doi.org\/10.1136\/gut.12.10.773","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,10]]}}}