{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T13:06:53Z","timestamp":1765631213268,"version":"3.48.0"},"reference-count":16,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1971,10]]},"abstract":"<jats:p>\n                    The lymphocytes of patients with coeliac disease are shown to have a significant diminution of proliferative and cytotoxic capacity as compared to normal lymphocytes when challenged\n                    <jats:italic>in vitro<\/jats:italic>\n                    with tumour cells from a lymphoma cell line. This impaired responsiveness is partly related to an intrinsic cellular defect but an inhibiting factor in the serum of coeliac patients has also been demonstrated.\n                  <\/jats:p>\n                  <jats:p>\n                    The impaired coeliac lymphocyte response in this\n                    <jats:italic>in-vitro<\/jats:italic>\n                    test system may serve as an indicator of a comparable defect in immune surveillance\n                    <jats:italic>in vivo.<\/jats:italic>\n                    This would account for the increased incidence of lymphosarcoma known to arise in patients with longstanding coeliac disease and might also explain the raised incidence of other gut-related tumours in these patients.\n                  <\/jats:p>","DOI":"10.1136\/gut.12.10.794","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"794-800","source":"Crossref","is-referenced-by-count":21,"title":["Impaired lymphocyte reactivity against tumour cells in patients with coeliac disease"],"prefix":"10.1136","volume":"12","author":[{"given":"B. P.","family":"Maclaurin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. T.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. R.","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1971,10,1]]},"reference":[{"key":"ref_1","first-page":"475","article-title":"Steatorrhea and malignant lymphoma","volume":"12","author":"Austad, W.I.; Cornes, J.S.; Gough, K.R.; McCarthy, C.F.; Read, A.E.","year":"1967","unstructured":"Austad, W. I., Cornes, J. S., Gough, K. R., McCarthy, C. F., and Read, A. E. (1967). Steatorrhea and malignant lymphoma. Amer. J. dig. Dis., 12, 475-490.","journal-title":"Amer. J. dig. Dis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/gut.10.1.57","article-title":"Serum immunoglobulins and lymphocyte transformation studies in coeliac disease","volume":"10","author":"Blecher, T.E.; Brzechwa-Ajdukiewicz, A.; McCarthy, C.F.; Read, A.E.","year":"1969","unstructured":"Blecher, T. E., Brzechwa-Ajdukiewicz, A., McCarthy, C. F., and Read, A. E. (1969). Serum immunoglobulins and lymphocyte transformation studies in coeliac disease. Gut, 10, 57-62.","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0140-6736(68)91971-5","article-title":"A modern basis for pathology","volume":"1","author":"Burnet, F.M.","year":"1968","unstructured":"Burnet, F. M. (1968). A modern basis for pathology. 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