{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T22:15:39Z","timestamp":1759702539704,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1971,11]]},"abstract":"<jats:p>The prevalence of circulating antibodies to gastric intrinsic factor and parietal cells was examined in 60 patients with histologically proven gastric carcinoma and was found not to differ from the prevalence of these antibodies in control subjects of similar age and sex distribution.<\/jats:p>\n               <jats:p>Amongst the 60 patients with gastric carcinoma seven were thought to have actual or potential pernicious anaemia.<\/jats:p>\n               <jats:p>The absence of an increased prevalence of antigastric antibodies in gastric carcinoma indicates that gastritis itself, whether autoimmune or not, is the likely common denominator underlying the predisposition to gastric carcinoma in both pernicious anaemia and chronic atrophic gastritis.<\/jats:p>","DOI":"10.1136\/gut.12.11.903","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"903-905","source":"Crossref","is-referenced-by-count":10,"title":["The prevalence and significance of circulating antibodies to gastric intrinsic factor and parietal cells in gastric carcinoma"],"prefix":"10.1136","volume":"12","author":[{"given":"Berta","family":"Ungar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. G.","family":"Strickland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Francis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1971,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/jcp.17.1.14","article-title":"Investigations into the Euglena method for the assay of vitamin B1, in serum","volume":"17","author":"Anderson, B.B.","year":"1964","unstructured":"Anderson, B. B. (1964). Investigations into the Euglena method for the assay of vitamin B1, in serum. J. clin. Path., 17, 14-26.","journal-title":"J. clin. Path"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1182\/blood.V25.6.875.875","article-title":"Rapid charcoal assay for intrinsic factor (IF), gastric juice unsaturated B1, binding capacity, antibody to IF and serum unsaturated B,, binding capacity","volume":"25","author":"Gottlieb, C.; Lau, K.S.; Wasserman, L.R.; Herbert, V.","year":"1965","unstructured":"Gottlieb, C., Lau, K. S., Wasserman, L. R., and Herbert, V. (1965). Rapid charcoal assay for intrinsic factor (IF), gastric juice unsaturated B1, binding capacity, antibody to IF and serum unsaturated B,, binding capacity. Blood, 25, 875-884.","journal-title":"Blood"},{"key":"ref_3","first-page":"99","article-title":"Immunoassay of gastric intrinsic factor and the titration of antibody to intrinsic factor","volume":"1","author":"Irvine, W.J.","year":"1966","unstructured":"Irvine, W. J. (1966). Immunoassay of gastric intrinsic factor and the titration of antibody to intrinsic factor. Clin. exp. Immunol., 1, 99-118.","journal-title":"Clin. exp. Immunol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00000441-194503000-00008","article-title":"Pernicious anaemia and carcinoma of the stomach","volume":"209","author":"Kaplan, H.S.; Rigler, L.G.","year":"1945","unstructured":"Kaplan, H. S., and Rigler, L. G. (1945). Pernicious anaemia and carcinoma of the stomach. Amer. J. med. Sci., 209, 339-348.","journal-title":"Amer. J. med. Sci"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0140-6736(67)91299-8","article-title":"Parietal-cell antibodies in patients with duodenal ulcer and gastric cancer","volume":"1","author":"Kravetz, R.E.; Van Noorden, S.; Spiro, H.M.","year":"1967","unstructured":"Kravetz, R. E., Van Noorden, S.,and Spiro, H. M. (1967). Parietal-cell antibodies in patients with duodenal ulcer and gastric cancer. Lancet, 1, 235-237.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/bmj.2.4675.390","article-title":"Mortality from and risk of gastric carcinoma among patients with pernicious anaemia","volume":"2","author":"Mosbech, J.; Videbaek, A.","year":"1950","unstructured":"Mosbech, J., and Videbaek, A. (1950). Mortality from and risk of gastric carcinoma among patients with pernicious anaemia. Brit. med. J., 2, 390-394.","journal-title":"Brit. med. J"},{"key":"ref_7","first-page":"403","article-title":"Carcinoma of the stomach and early pernicious anaemia","volume":"2","author":"Shearman, D.J.C.; Finlayson, N.D.C.; Wilson, R.; Samson, R.R.","year":"1966","unstructured":"Shearman, D. J. C., Finlayson, N. D. C., Wilson, R., and Samson, R. R. (1966). Carcinoma of the stomach and early pernicious anaemia. Lancet, 2, 403-405.","journal-title":"Lancet"},{"key":"ref_8","first-page":"419","article-title":"Natural history of chronic atrophic gastritis","volume":"19","author":"Strickland, R.G.; Ungar, B.; Mackay, I.R.","year":"1970","unstructured":"Strickland, R. G., Ungar, B., and Mackay, I. R. (1970). Natural history of chronic atrophic gastritis. Aust. Ann. Med., 19, 419.","journal-title":"Aust. Ann. Med"},{"key":"ref_9","article-title":"Parietal Cell Antibodies, Chronic Gastritis and Pernicious Anaemia","author":"Te Velde, K.","year":"1967","unstructured":"Te Velde, K. (1967). Parietal Cell Antibodies, Chronic Gastritis and Pernicious Anaemia. Thesis, State University, Groningen, Netherlands."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/icb.1967.28","article-title":"Detection and titration of antibody to intrinsic factor by a modified charcoal method","volume":"45","author":"Ungar, B.","year":"1967","unstructured":"Ungar, B. (1967). Detection and titration of antibody to intrinsic factor by a modified charcoal method. Aust. J. exp. Biol. med. Sci., 45, 317-321.","journal-title":"Aust. J. exp. Biol. med. Sci"},{"key":"ref_11","first-page":"107","article-title":"Antibody to gastric intrinsic factor in blood donors and hospital patients","volume":"17","author":"Ungar, B.","year":"1968","unstructured":"Ungar, B. (1968). Antibody to gastric intrinsic factor in blood donors and hospital patients. Aust. Ann. Med., 17, 107-109.","journal-title":"Aust. Ann. Med"},{"key":"ref_12","first-page":"415","article-title":"Intrinsic-factor antibody, parietal-cell antibody, and latent pernicious anaemia in diabetes mellitus","volume":"2","author":"Ungar, B.; Stocks, A.E.; Martin, F.I.R.; Whittingbam, S.; Mackay, I.R.","year":"1968","unstructured":"Ungar, B., Stocks, A. E., Martin, F. I. R., Whittingbam, S., and Mackay, I. R. (1968). Intrinsic-factor antibody, parietal-cell antibody, and latent pernicious anaemia in diabetes mellitus. Lancet, 2, 415-418.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1136\/gut.12.11.906","article-title":"Simple atrophic gastritis and gastric carcinoma","volume":"12","author":"Walker, I.R.; Strickland, R.G.; Ungar, B.; Mackay, I.R.","year":"1971","unstructured":"Walker, I. R., Strickland, R. G., Ungar, B., and Mackay, I. R. (1971). Simple atrophic gastritis and gastric carcinoma. Gut, 12, 906-911.","journal-title":"Gut"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.5694\/j.1326-5377.1969.tb62269.x","article-title":"Laboratory methods for diagnosis of autoimmune disease","volume":"1","author":"Whittingham, S.; Mackay, I.R.","year":"1969","unstructured":"Whittingham, S., and Mackay, I. R. (1969). Laboratory methods for diagnosis of autoimmune disease. Med. J. Aust., 1, 1200-1205.","journal-title":"Med. J. Aust"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.12.11.903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:48:12Z","timestamp":1757314092000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.12.11.903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,11]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1971,11,1]]},"published-print":{"date-parts":[[1971,11]]}},"alternative-id":["10.1136\/gut.12.11.903"],"URL":"https:\/\/doi.org\/10.1136\/gut.12.11.903","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1971,11]]}}}