{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:42:32Z","timestamp":1765078952106,"version":"3.46.0"},"reference-count":16,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1972,11]]},"abstract":"<jats:p>The rosette inhibition test was used to measure serum immunosuppressive activity after azathioprine (1\u00b75 mg\/kg) in 20 patients with liver disease (10 with active chronic hepatitis, six with primary biliary cirrhosis, and four with miscellaneous hepatic disorders) and in nine healthy normal volunteers. Where possible testing was repeated after one week and after at least two months of treatment. The titre of immunosuppression was related to the degree of impairment of hepatic function, and was found to be low in those with severe and normal in those with mild disturbance of hepatic function. Titres were unrelated to the presence of immunological abnormalities such as smooth muscle antibodies. In patients treated for at least two months there was no relationship between the initial titre of immunosuppressive activity and the response to treatment. Thus some patients improved despite failure to develop immunosuppressive activity, while others deteriorated even though immunosuppressive activity was normal when first studied. The development of immunosuppressive activity after azathioprine seems to be dependent on adequate hepatic function and the favourable response of some patients with liver disease to the drug may not be due entirely to immunosuppression.<\/jats:p>","DOI":"10.1136\/gut.13.11.907","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"907-914","source":"Crossref","is-referenced-by-count":17,"title":["Immunosuppressive activity in patients with active chronic hepatitis and primary biliary cirrhosis treated with azathioprine"],"prefix":"10.1136","volume":"13","author":[{"given":"Gregory","family":"Whelan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Sherlock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,11,1]]},"reference":[{"key":"ref_1","first-page":"189","article-title":"Mechanism and significance of rosette inhibition by antilymphocyte serum","volume-title":"International Symposium on Antilymphocytic Serum, Versailles","volume":"16","author":"Bach, J.F.","year":"1970","unstructured":"Bach, J. F. (1970). Mechanism and significance of rosette inhibition by antilymphocyte serum. In International Symposium on Antilymphocytic Serum, Versailles, 1970, edited by J. F. Bach et aol (Symposia series in Immunoglobulin Standardization, vol. 16), pp. 189-198."},{"key":"ref_2","first-page":"453","article-title":"ttudes sur le m6tabolisme de l'azathioprine","volume":"271","author":"Bach, J.F.; Dardenne, M.","year":"1970","unstructured":"Bach, J. F., and Dardenne, M. (1970). ttudes sur le m6tabolisme de l'azathioprine. C.R. Acad. Sci. Paris D, 271, 453-456.","journal-title":"C. R. Acad. Sci. Paris D"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/222998a0","article-title":"In vitro evaluation of immunosuppressive drugs","volume":"222","author":"Bach, J.F.; Dardenne, M.; Fournier, C.","year":"1969","unstructured":"Bach, J. F., Dardenne, M., and Fournier, C. (1969a). In vitro evaluation of immunosuppressive drugs. Nature (Lond.), 222, 998-999.","journal-title":"Nature (Lond.)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/00007890-197101000-00016","article-title":"Further developments of the rosette inhibition test for the testing of antihuman lymphocyte serum","volume":"11","author":"Bach, J.F.; Dormont, J.","year":"1971","unstructured":"Bach, J. F., and Dormont, J. (1971). Further developments of the rosette inhibition test for the testing of antihuman lymphocyte serum. Transplantation, 11, 96-100.","journal-title":"Transplantation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00007890-196909000-00008","article-title":"In vitro rosette inhibition by antihuman antilymphocyte serum","volume":"8","author":"Bach, J.F.; Dormont, J.; Dandenne, M.; Balner, H.","year":"1969","unstructured":"Bach, J. F., Dormont, J., Dandenne, M., and Balner, H. (1969b). In vitro rosette inhibition by antihuman antilymphocyte serum. Transplantation, 8, 265-280.","journal-title":"Transplantation"},{"key":"ref_6","first-page":"898","article-title":"Biochemistry and pharmacology of purine analogues","volume":"26","author":"Elion, G.B.","year":"1967","unstructured":"Elion, G. B. (1967a). Biochemistry and pharmacology of purine analogues. Fed. Proc., 26, 898-903.","journal-title":"Fed. Proc"},{"key":"ref_7","first-page":"399","volume-title":"Immunopathology: Mechanisms of Inflammation Induced by Immune Reactions: 5th International Symposium on Immunopathology, Punta Ala","author":"Elion, G.B.","year":"1967","unstructured":"Elion, G. B. (1967b). In Immunopathology: Mechanisms of Inflammation Induced by Immune Reactions: 5th International Symposium on Immunopathology, Punta Ala, edited by P. A. Miescher and P. Grabar, pp. 399-401. Grune and Stratton, New York."},{"key":"ref_8","first-page":"2448","article-title":"Action of purine analogs: enzyme specificity studies as a basis for interpretation and design","volume":"29","author":"Elion, G.B.","year":"1969","unstructured":"Elion, G. B. (1969). Action of purine analogs: enzyme specificity studies as a basis for interpretation and design. Cancer Res., 29, 2448-2453.","journal-title":"Cancer Res"},{"key":"ref_9","first-page":"257","article-title":"Significance ofazathioprine metabolites","volume":"65","author":"Elion, G.B.","year":"1972","unstructured":"Elion, G. B. (1972). Significance ofazathioprine metabolites. Proc. roy. Soc. Med., 65, 257-260.","journal-title":"Proc. roy. Soc. Med"},{"key":"ref_10","first-page":"379","article-title":"Chronic hepatitis: effect of prolonged suppressive treatment and comparison of azathioprine with prednisolone","volume":"37","author":"Mackay, I.R.","year":"1968","unstructured":"Mackay, I. R. (1968). Chronic hepatitis: effect of prolonged suppressive treatment and comparison of azathioprine with prednisolone. Quart. J. Med., 37, 379-392.","journal-title":"Quart. J. Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0140-6736(64)91627-7","article-title":"Treatment of active chronic hepatitis and lupoid hepatitis with 6-mercaptopurine and azathioprine","volume":"1","author":"Mackay, I.R.; Weiden, S.; Ungar, B.","year":"1964","unstructured":"Mackay, I. R., Weiden, S., and Ungar, B. (1964). Treatment of active chronic hepatitis and lupoid hepatitis with 6-mercaptopurine and azathioprine. Lancet, 1, 899-902.","journal-title":"Lancet"},{"key":"ref_12","first-page":"305","article-title":"The treatment of active chronic hepatitis with 6-mercaptopurine and azathioprine","volume":"16","author":"Mistilis, S.P.; Blackburn, C.R.B.","year":"1967","unstructured":"Mistilis, S. P., and Blackburn, C. R. B. (1967). The treatment of active chronic hepatitis with 6-mercaptopurine and azathioprine. Aust. Ann. Med., 16, 305-311.","journal-title":"Aust. Ann. Med"},{"key":"ref_13","first-page":"1196","article-title":"Serum immunosuppressive activity due to azathioprine and its relation to hepatic function after liver transplantation","volume":"1","author":"Mitchell, C.G.; Eddleston, A.L.W.F.; Smith, M.G.M.; Williams, R.","year":"1970","unstructured":"Mitchell, C. G., Eddleston, A. L. W. F., Smith, M. G. M., and Williams, R. (1970). Serum immunosuppressive activity due to azathioprine and its relation to hepatic function after liver transplantation. Lancet, 1, 1196-1199.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0002-9343(69)90169-7","article-title":"Long term results of therapy in patients with chronic liver disease associated with hypergammaglobulinemia","volume":"47","author":"Page, A.R.; Good, R.A.; Pollara, B.","year":"1969","unstructured":"Page, A. R., Good, R. A., and Pollara, B. (1969). Long term results of therapy in patients with chronic liver disease associated with hypergammaglobulinemia. Amer. J. Med., 47, 765-774.","journal-title":"Amer. J. Med"},{"key":"ref_15","article-title":"Liver Biopsy Interpretation","author":"Scheuer, P.J.","year":"1968","unstructured":"Scheuer, P. J. (1968). Liver Biopsy Interpretation. Bailliere, Tindall, Cassell, London."},{"key":"ref_16","article-title":"NonParametric Statistics for the Behavioral Sciences","author":"Siegel, S.","year":"1956","unstructured":"Siegel, S. (1956). NonParametric Statistics for the Behavioral Sciences. 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