{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:45:51Z","timestamp":1765637151353,"version":"3.48.0"},"reference-count":30,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1972,2]]},"abstract":"<jats:p>\n                    The results of pancreatic scanning with\n                    <jats:sup>75<\/jats:sup>\n                    Se-selenomethionine in 393 carefully documented patients over a two-year period are presented. On follow up 50 patients had operatively proven malignant tumours in the gland and a further 22 had similar tumours in adjacent organs, clinically mimicking carcinoma of the pancreas and in many cases causing scan abnormalities. Five patients had pancreatic adenomata. Remote tumours rarely affected the scan. Examination of the role of scanning in patients with neoplastic disease revealed that the test was effective in screening and in detection; false negative diagnoses were rare. By contrast, survival following diagnosis was extremely poor with only 8% of pancreatic tumours resectable and 50% metastasized at the time of surgery. Causes of pancreatic dysfunction, other than pancreatitis or carcinoma, which were associated with abnormalities on the scan are described and general aspects of reporting on the scan are discussed. The patterns seen in abnormal scans, while non-specific with regard to aetiology, were anatomically meaningful and useful adjuncts to the diagnosis of pancreatic disease. A normal scan excluded pancreatic cancer with a probability greater than 95%.\n                  <\/jats:p>","DOI":"10.1136\/gut.13.2.75","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"75-87","source":"Crossref","is-referenced-by-count":25,"title":["<sup>75<\/sup>\n                    Se-selenomethionine scanning in the diagnosis of tumours of the pancreas and adjacent viscera: The use of the test and its impact on survival"],"prefix":"10.1136","volume":"13","author":[{"given":"Denis M.","family":"McCarthy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. N.","family":"Melmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Agnew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. A. D.","family":"Bouchier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1259\/0007-1285-42-502-762","article-title":"Count rate analysis as an adjunct to the \"Seselenomethionine pancreas scan","volume":"42","author":"Agnew, J.E.; McCarthy, D.M.; Melmed, R.N.; Bouchier, I.A.D.","year":"1969","unstructured":"Agnew, J. E., McCarthy, D. M., Melmed, R. N., and Bouchier, I. A. D. (1969). Count rate analysis as an adjunct to the \"Seselenomethionine pancreas scan. Brit. J. Radiol., 42, 762-769.","journal-title":"Brit. J. Radiol"},{"key":"ref_2","first-page":"409","article-title":"Int6ret et limites de la scintigraphie du pancr6as","volume":"33","author":"Blanquet, P.; Doutre, L.P.; Beck, C.; Ducassou, D.","year":"1970","unstructured":"Blanquet, P., Doutre, L. P., Beck, C., and Ducassou, D. (1970). Int6ret et limites de la scintigraphie du pancr6as. Acta gastroent. beig., 33, 409-421.","journal-title":"Acta gastroent. beig"},{"key":"ref_3","first-page":"275","article-title":"Pancreas scanning with Se75-selenomethionine. In Medical Radioisotope Scanning, Vol","author":"Blau, M.","year":"1964","unstructured":"Blau, M. (1964). Pancreas scanning with Se75-selenomethionine. In Medical Radioisotope Scanning, Vol. II, pp. 275-287. International Atomic Energy Agency, Vienna."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1148\/78.6.974","article-title":"Se'7-selenomethionine for visualization of the pancreas by isotope scanning","volume":"78","author":"Blau, M.; Bender, M.A.","year":"1962","unstructured":"Blau, M., and Bender, M. A. (1962). Se'7-selenomethionine for visualization of the pancreas by isotope scanning. Radiology, 78, 974.","journal-title":"Radiology"},{"key":"ref_5","first-page":"194","article-title":"Diagnosis of pancreatic carcinoma by photoscanning","author":"Burdine, J.A.; Haynie, T.P.","year":"1965","unstructured":"Burdine, J. A., and Haynie, T. P. (1965). Diagnosis of pancreatic carcinoma by photoscanning. J. Amer. med. Ass., 194,979-983.","journal-title":"J. Amer. med. Ass"},{"key":"ref_6","first-page":"1156","article-title":"Radioisotope photoscanning in the diagnosis ofpancreatic disease","volume":"92","author":"Burke, G.; Goldstein, M.S.","year":"1964","unstructured":"Burke, G., and Goldstein, M. S. (1964). Radioisotope photoscanning in the diagnosis ofpancreatic disease. Amer. J. Roentgenol., 92, 1156-1161.","journal-title":"Amer. J. Roentgenol"},{"key":"ref_7","first-page":"662669","article-title":"Experiences in pancreas scanning using \"5Se-selenomethionine. Brit","volume":"40","author":"Centi Colella, A.; Pigorini, F.","year":"1967","unstructured":"Centi Colella, A., and Pigorini, F. (1967). Experiences in pancreas scanning using \"5Se-selenomethionine. Brit. J. Radiol., 40, 662669.","journal-title":"J. Radiol"},{"key":"ref_8","article-title":"Problems ofinterpretation of isotope scans of the normal and abnormal pancreas. Atti del XXIII Congresso Nazionale di Radiologia e Medicina Nucleare, Padua","author":"Centi-Colella, A.; Pigorini, F.","year":"1968","unstructured":"Centi-Colella, A., and Pigorini, F. (1968). Problems ofinterpretation of isotope scans of the normal and abnormal pancreas. Atti del XXIII Congresso Nazionale di Radiologia e Medicina Nucleare, Padua, 1968."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1056\/NEJM196808222790801","article-title":"Comparison of current radiologic approaches to the diagnosis of pancreatic disease","volume":"279","author":"Eaton, S.B.Fleischli; J., D.; Pollard, J.J.; Nebesar, R.A.; Potsaid, M.S.","year":"1968","unstructured":"Eaton, S. B. Fleischli, D. J., Pollard, J. J., Nebesar, R. A., and Potsaid, M. S. (1968). Comparison of current radiologic approaches to the diagnosis of pancreatic disease. New Engl. J. Med., 279, 389-396.","journal-title":"New Engl. J. Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/1097-0142(196710)20:10<1663::AID-CNCR2820201014>3.0.CO;2-D","article-title":"Circulating antibodies against carcinomembryonic antigens of the human digestive system","volume":"20","author":"Gold, P.","year":"1967","unstructured":"Gold, P. (1967). Circulating antibodies against carcinomembryonic antigens of the human digestive system. Cancer (Philad.), 20, 1663-1667.","journal-title":"Cancer (Philad.)"},{"key":"ref_11","first-page":"387","article-title":"Radioisotope scanning of pancreas carcinoma","volume":"8","author":"Kakehi, H.; Tateno, Y.; Uchiyama, G.; Tsuchiya, S.","year":"1967","unstructured":"Kakehi, H., Tateno, Y., Uchiyama, G., and Tsuchiya, S. (1967). Radioisotope scanning of pancreas carcinoma. (Abstr.) J. nucl. Med., 8, 387-388.","journal-title":"(Abstr.) J. nucl. Med"},{"key":"ref_12","first-page":"349","article-title":"Evaluation of pancreatic disease by dual channel scanning","volume":"8","author":"Kaplan, E.; Ben-Porath, M.; Fink, S.; Clayton, G.D.; Jacobson, B.","year":"1967","unstructured":"Kaplan, E., Ben-Porath, M., Fink, S., Clayton, G. D., and Jacobson, B. (1967). Evaluation of pancreatic disease by dual channel scanning. (Abstr.) J. nucl. Med., 8, 349.","journal-title":"(Abstr.) J. nucl. Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2214\/ajr.96.3.657","article-title":"A study of the morphology of the normal pancreas using Se'7-methionine photoscanning","volume":"96","author":"King, E.R.; Sharpe, A.; Grubb, W.; Brock, J.S.; Greenberg, L.","year":"1966","unstructured":"King, E. R., Sharpe, A., Grubb, W., Brock, J. S., and Greenberg, L. (1966). A study of the morphology of the normal pancreas using Se'7-methionine photoscanning. Amer. J. Roentgenol., 96, 657-663.","journal-title":"Amer. J. Roentgenol"},{"key":"ref_14","first-page":"115","article-title":"Isotope scanning of the pancreas as a diagnostic aid in some cases of pancreatic disease","volume":"55","author":"Lahdevirta, J.; Rasanen, T.; Haikonen, M.","year":"1966","unstructured":"Lahdevirta, J., Rasanen, T., and Haikonen, M. (1966). Isotope scanning of the pancreas as a diagnostic aid in some cases of pancreatic disease. Ann. Med. intern. Fenn., 55, 115-119.","journal-title":"Ann. Med. intern. Fenn"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.0954-6820.1970.tb08007.x","article-title":"Evaluation of pancreatic scanning","volume":"188","author":"Liewendahl, K.; Kvist, G.","year":"1970","unstructured":"Liewendahl, K., and Kvist, G. (1970). Evaluation of pancreatic scanning. Acta. med. scand., 188, 75-80.","journal-title":"Acta. med. scand"},{"key":"ref_16","article-title":"Pancreatic scanning","author":"McCarthy, D.M.","year":"1970","unstructured":"McCarthy, D. M. (1970). Pancreatic scanning. MD Thesis, University College Dublin (NUI)."},{"key":"ref_17","volume-title":"Scanning in pancreatitis. In Pancreatitis","author":"McCarthy, D.M.","year":"1972","unstructured":"McCarthy, D. M. (1972). Scanning in pancreatitis. In Pancreatitis, edited by 0. Fitzgerald and J. McMullin. London (in press)."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1136\/gut.10.11.913","article-title":"Measurement of duodenal tryptic activity and 75Se-selenomethionine pancreatic scanning compared as tests of pancreatic function","volume":"10","author":"McCarthy, D.M.; Brown, P.","year":"1969","unstructured":"McCarthy, D. M., and Brown, P. (1969). Measurement of duodenal tryptic activity and 75Se-selenomethionine pancreatic scanning compared as tests of pancreatic function. Gut, 10, 913-920.","journal-title":"Gut"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/gut.10.8.665","article-title":"Value of hypotonic duodenography as an adjunct to pancreatic scanning","volume":"10","author":"McCarthy, D.M.; Kreel, L.; Agnew, J.E.; Bouchier, I.A.D.","year":"1969","unstructured":"McCarthy, D. M., Kreel, L., Agnew, J. E., and Bouchier, I. A. D. (1969). Value of hypotonic duodenography as an adjunct to pancreatic scanning. Gut, 10, 665-673.","journal-title":"Gut"},{"key":"ref_20","first-page":"504","article-title":"Rilievi scintigrafici ottenuti con seleniometionina radioattiva nelle pancreatiti acute e croniche","volume":"53","author":"Marabini, A.; Donati, E.; Cabassa, N.; Gagni, G.","year":"1967","unstructured":"Marabini, A., Donati, E., Cabassa, N., and Gagni, G. (1967). Rilievi scintigrafici ottenuti con seleniometionina radioattiva nelle pancreatiti acute e croniche. (Abstr.) Radiol. med. (Torino), 53, 504.","journal-title":"(Abstr.) Radiol. med. (Torino)"},{"key":"ref_21","first-page":"607","article-title":"The normal and abnormal pancreatic scan","volume":"37","author":"Melmed, R.N.; Agnew, J.E.; Bouchier, I.A.D.","year":"1968","unstructured":"Melmed, R. N., Agnew, J. E., and Bouchier, I. A. D. (1968). The normal and abnormal pancreatic scan. Quart. J. Med., n.s., 37, 607-624.","journal-title":"Quart. J. Med., n.s"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02233781","article-title":"Carcinoembryonic antigen assay in cancer of the colon and pancreas and other digestive tract disorders","volume":"16","author":"Moore, T.L.; Zupchik, H.Z.; Marcon, N.; Zamcheck, N.","year":"1971","unstructured":"Moore, T. L., Zupchik, H. Z., Marcon, N., and Zamcheck, N. (1971). Carcinoembryonic antigen assay in cancer of the colon and pancreas and other digestive tract disorders. Amer. J. dig. Dis., 16, 1-7.","journal-title":"Amer. J. dig. Dis"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0037-198X(68)90010-2","article-title":"Pancreatic scanning","volume":"3","author":"Riccobono, X.J.","year":"1968","unstructured":"Riccobono, X. J. (1968). Pancreatic scanning. Semin. Roentgenol., 3, 310-317.","journal-title":"Semin. Roentgenol"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"730","DOI":"10.7326\/0003-4819-65-4-730","article-title":"Photoscanning in diagnosis of carcinoma of the pancreas","volume":"65","author":"Rodriguez-Antunez, A.; Filson, E.J.; Sullivan, Jr., B.H.; Brown, C.H.","year":"1966","unstructured":"Rodriguez-Antunez, A., Filson, E. J., Sullivan, B. H., Jr., and Brown, C. H. (1966). Photoscanning in diagnosis of carcinoma of the pancreas. Ann. intern. Med., 65, 730-737.","journal-title":"Ann. intern. Med"},{"key":"ref_25","first-page":"454","article-title":"The clinical correlation of isotope pancreatography","volume":"45","author":"Sodee, D.B.","year":"1966","unstructured":"Sodee, D. B. (1966). The clinical correlation of isotope pancreatography. Amer. J. Gastroent., 45, 454-459.","journal-title":"Amer. J. Gastroent"},{"key":"ref_26","first-page":"285","article-title":"Bisherige Engebnisse der Pancreasszyintigraphie mit \"Se-Methionin","volume":"98","author":"Steinhoff, H.; Pabst, H.W.","year":"1968","unstructured":"Steinhoff, H., and Pabst, H. W. (1968). Bisherige Engebnisse der Pancreasszyintigraphie mit \"Se-Methionin. Schweiz. med. Wschr., 98, 285-287.","journal-title":"Schweiz. med. Wschr"},{"key":"ref_27","first-page":"773782","article-title":"L'exploration isotopique du pancr6as par la s6l6nom6thionine: a propos de 60 observations","volume":"12","author":"Swyngedauw, J.; Tacquet, A.; Foissac-Gegoux, P.; Huart, M.","year":"1967","unstructured":"Swyngedauw, J., Tacquet, A., Foissac-Gegoux, P., and Huart, M. (1967). L'exploration isotopique du pancr6as par la s6l6nom6thionine: a propos de 60 observations. Lille med., 12, 773782.","journal-title":"Lille med"},{"key":"ref_28","first-page":"197","article-title":"La pancreatographie par les isotopes radioactifs","volume":"29","author":"Van Vaerenbergh, Jr., M.; Van Vaerenbergh, P.M.; Demeulenaere, L.; Yvergneaux, J.P.; Barbier, F.","year":"1966","unstructured":"Van Vaerenbergh, M., Jr., Van Vaerenbergh, P. M., Demeulenaere, L., Yvergneaux, J. P., and Barbier, F. (1966). La pancreatographie par les isotopes radioactifs. Acta gastro-ent. belg., 29, 197-210.","journal-title":"Acta gastro-ent. belg"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/bmj.2.5756.252","article-title":"Radioselenium in duodenal aspirate as an assessment of pancreatic exocrine function","volume":"2","author":"Youngs, G.R.; Agnew, J.E.; Levin, G.E.; Bouchier, I.A.D.","year":"1971","unstructured":"Youngs, G. R., Agnew, J. E., Levin, G. E., and Bouchier, I. A. D. (1971). Radioselenium in duodenal aspirate as an assessment of pancreatic exocrine function. Brit. med. J., 2, 252-255.","journal-title":"Brit. med. J"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/00000658-196311000-00020","article-title":"Pancr6atic uptake of Se7-selenomethionine","volume":"158","author":"Zuidema, G.D.; Kirsh, M.; Turcotte, J.G.; Gaisford, W.D.; Powers, W.; Kowalczyk, R.S.","year":"1963","unstructured":"Zuidema, G. D., Kirsh, M., Turcotte, J. G., Gaisford, W. D., Powers, W., and Kowalczyk, R. S. (1963). Pancr6atic uptake of Se7-selenomethionine. Ann. Surg., 158, 894-897.","journal-title":"Ann. Surg"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.13.2.75","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:42:11Z","timestamp":1765636931000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.13.2.75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,2]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1972,2,1]]},"published-print":{"date-parts":[[1972,2]]}},"alternative-id":["10.1136\/gut.13.2.75"],"URL":"https:\/\/doi.org\/10.1136\/gut.13.2.75","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1972,2]]}}}