{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:35:03Z","timestamp":1771630503347,"version":"3.50.1"},"reference-count":9,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1972,3]]},"abstract":"<jats:p>\n                    Colonic motility studies using time-lapse cinefluorography and intraluminal pressure recording before and after the introduction\n                    <jats:italic>per rectum<\/jats:italic>\n                    of a mixture of barium sulphate and oxyphenisatin solution show the different forms of movement of the colonic contents.\n                  <\/jats:p>\n                  <jats:p>Oxyphenisatin was found to be a selective actuator of a form of progressive mass propulsion indistinguishable from spontaneous mass peristalsis. Less than 0\u00b75 mg distributed through the pelvic and distal descending colon was enough to produce a peristaltic response; larger quantities tended to increase the number of resulting movements.<\/jats:p>\n                  <jats:p>A standard dose of 4 mg of the drug was followed by mass peristalsis in 82% of the subjects in whom it came into adequate contact with colonic mucosa. The response usually took place within 20 minutes. The more sensitive the subject, the greater was the number of peristaltic responses and the shorter the interval before the response began.<\/jats:p>\n                  <jats:p>In 73% of the subjects who responded, the mass peristalsis came to a halt between 40 and 25 cm from the anal margin, and many of those in whom it extended farther appeared to have shortened distal colons. The likelihood of the drug giving rise to peristalsis diminished abruptly distal to about 45 cm from the anus; its effectiveness was greatest in the proximal descending colon.<\/jats:p>","DOI":"10.1136\/gut.13.3.211","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"211-219","source":"Crossref","is-referenced-by-count":47,"title":["Mass peristalsis in the human colon after contact with oxyphenisatin"],"prefix":"10.1136","volume":"13","author":[{"given":"James","family":"Ritchie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1113\/jphysiol.1900.sp000825","article-title":"The movements and the innervation of the large intestine","volume":"26","author":"Bayliss, W.M.; Starling, E.H.","year":"1900","unstructured":"Bayliss, W. M., and Starling, E. H. (1900). The movements and the innervation of the large intestine. J. Physiol. (Lond.), 26, 107-118.","journal-title":"J. Physiol. (Lond.)"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/gut.11.1.41","article-title":"Physical factors in the stimulation of colonic peristalsis","volume":"11","author":"Hardcastle, J.D.; Mann, C.V.","year":"1970","unstructured":"Hardcastle, J. D., and Mann, C. V. (1970). Physical factors in the stimulation of colonic peristalsis. Gut, 11, 41-46.","journal-title":"Gut"},{"key":"ref_3","first-page":"633","article-title":"A study of colonic peristalsis","volume":"8","author":"Hardcastle, J.D.; Mann, C.V.; Parks, A.G.; Murray, R.S.","year":"1967","unstructured":"Hardcastle, J. D., Mann, C. V., Parks, A. G., and Murray, R. S. (1967). A study of colonic peristalsis. (Abstr.) Gut, 8, 633.","journal-title":"(Abstr.) Gut"},{"key":"ref_4","first-page":"560","article-title":"The mechanism by which senna glycosides and related compounds stimulate peristalsis in the human colon","volume-title":"Report of World Congress of Gastroenterology, Copenhagen","author":"Hardcastle, J.D.; Wilkins, J.L.","year":"1970","unstructured":"Hardcastle, J. D., and Wilkins, J. L. (1970). The mechanism by which senna glycosides and related compounds stimulate peristalsis in the human colon. In Report of World Congress of Gastroenterology, Copenhagen, p. 560."},{"key":"ref_5","first-page":"\"2401","article-title":"Die normale Peristaltik des Kolon","volume":"56","author":"Holznecht, G.","year":"1909","unstructured":"Holznecht, G. (1909). Die normale Peristaltik des Kolon. Munch. med. Wschr., 56, 2401-2403. (Abridged translation (1969) Amer. J. dig. Dis., 14, 57-60).","journal-title":"Munch. med. Wschr; Amer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/gut.9.4.442","article-title":"Colonic motor activity and bowel function. I. Normal movement of contents","volume":"9","author":"Ritchie, J.A.","year":"1968","unstructured":"Ritchie, J. A. (1968). Colonic motor activity and bowel function. I. Normal movement of contents. Gut, 9, 442-456.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/BF02239592","article-title":"Propulsion and retropulsion of normal colonic contents","volume":"16","author":"Ritchie, J.A.; Truelove, S.C.; Ardran, G.M.; Tuckey, M.S.","year":"1971","unstructured":"Ritchie, J. A., Truelove, S. C., Ardran, G. M., and Tuckey, M. S. (1971). Propulsion and retropulsion of normal colonic contents. Amer. J. dig. Dis., 16, 697-704.","journal-title":"Amer. J. dig. Dis"},{"key":"ref_8","first-page":"150","article-title":"Mass movements and intracolonic pressures","volume":"1","author":"Torsoli, A.; Ramorino, M.L.; Ammaturo, M.V.; Capurso, L.; Archangeli, G.; Pauluzi, P.","year":"1969","unstructured":"Torsoli, A., Ramorino, M. L., Ammaturo, M. V., Capurso, L., Archangeli, G., and Pauluzi, P. (1969). Mass movements and intracolonic pressures. Rendic. R. R. Gastroent., 1, 150-152.","journal-title":"Gastroent"},{"key":"ref_9","first-page":"813","article-title":"The observations of Reynolds and his coworkers since 1969 (Gastroenterology","volume":"56","author":"418, J","year":"1969","unstructured":"The observations of Reynolds and his coworkers since 1969 (Gastroenterology 1969, 56, 418; J. Amer. med. Ass., 1970, 211, 86; New Engl. J. Med., 1971, 285, 813) have shown that oxyphenisatin ingested in a daily dosage of 6 mg for at least 12 months may give rise to hepatitis. This appears to be a specific hypersensitivity reaction occurring in a few patients; challenge with the drug does not exacerbate hepatitis due to other causes. While this reaction makes its use as a regular oral aperient undesirable, oxyphenisatin remains at least as safe as the potassium soaps for occasional administration as an enema. A dose of 10-15 mg administered in this way, by actuating mass peristalsis, enables impacted scybala to be expelled even from the proximal part of the bowel efficiently and without discomfort.","journal-title":"Amer. med. Ass; 86; New Engl"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.13.3.211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T13:01:37Z","timestamp":1765630897000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.13.3.211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,3]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1972,3,1]]},"published-print":{"date-parts":[[1972,3]]}},"alternative-id":["10.1136\/gut.13.3.211"],"URL":"https:\/\/doi.org\/10.1136\/gut.13.3.211","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,3]]}}}