{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:44:07Z","timestamp":1768895047681,"version":"3.49.0"},"reference-count":15,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1972,3]]},"abstract":"<jats:p>\n                    Thirteen patients with Wilson's disease were compared with seven cirrhotic and 13 normal controls to define better the haematological abnormalities in this condition. Hypersplenism (anaemia, leukopenia, thrombocytopenia, and reduced red cell survival) commonly occurred in patients with both Wilson's disease and cirrhosis. These abnormalities correlated with splenic enlargement. Despite reduced haematocrits, red cell mass was greater in these two groups than in normal controls. Plasma volume and the body haematocrit\/peripheral haematocrit ratios were also greater in patients with Wilson's disease and cirrhosis. Increased splenic sequestration of\n                    <jats:sup>51<\/jats:sup>\n                    Cr-tagged red blood cells was not demonstrated in any subjects. The hypersplenism in patients with Wilson's disease is similar to that found in patients with cirrhosis from other causes.\n                  <\/jats:p>","DOI":"10.1136\/gut.13.3.220","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"220-224","source":"Crossref","is-referenced-by-count":10,"title":["Hypersplenism in Wilson's disease"],"prefix":"10.1136","volume":"13","author":[{"given":"G. Thomas","family":"Strickland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N-K.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Beckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI102102","article-title":"Hypervolemic anemia in cirrhosis","volume":"28","author":"Bateman, J.C.; Shorr, H.M.; Elgvin, T.","year":"1949","unstructured":"Bateman, J. C., Shorr, H. M., and Elgvin, T. (1949). Hypervolemic anemia in cirrhosis. J. clin. Invest., 28, 539-547.","journal-title":"J. clin. 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Science, 112, 179-180.","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1172\/JCI103087","article-title":"The anemia of liver disease. Observations on its mechanism","volume":"34","author":"Jandi, J.H.","year":"1955","unstructured":"Jandi, J. H. (1955). The anemia of liver disease. Observations on its mechanism. J. clin. Invest., 34, 390-404.","journal-title":"J. clin. Invest"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0016-5085(64)80101-3","article-title":"Red cell survival estimated by radioactive chromium in hepatobiliary disease","volume":"46","author":"Katz, R.; Velasco, M.; Guzman, C.; Alessandri, H.","year":"1964","unstructured":"Katz, R., Velasco, M., Guzman, C., and Alessandri, H. (1964). Red cell survival estimated by radioactive chromium in hepatobiliary disease. 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