{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:47:42Z","timestamp":1764996462084,"version":"3.46.0"},"reference-count":18,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1972,5]]},"abstract":"<jats:p>\n                    The release of\n                    <jats:sup>51<\/jats:sup>\n                    Cr from labelled colon cells was used to assess a possible lymphocytotoxic effect of peripheral blood lymphocytes from patients suffering from recurrent aphthous ulceration. No significant (p &gt; 0\u00b703) difference was observed between the isotope release following incubation with patients' or control lymphocytes. The absence of such a lymphocytotoxic effect, detectable with oral epithelial cells, is discussed in relation to the role of cellular hypersensitivity in the pathogenesis of ulcerative colitis and aphthous ulceration.\n                  <\/jats:p>","DOI":"10.1136\/gut.13.5.387","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"387-389","source":"Crossref","is-referenced-by-count":12,"title":["The effect of lymphocytes from sufferers from recurrent aphthous ulceration upon colon cells in tissue culture"],"prefix":"10.1136","volume":"13","author":[{"given":"A. E.","family":"Dolby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1084\/jem.115.1.13","article-title":"Demonstration of an epithelial antigen in colon by means of fluorescent antibodies from children with ulcerative colitis","volume":"115","author":"Broberger, O.; Perlmann, P.","year":"1962","unstructured":"Broberger, O., and Perlmann, P. (1962). Demonstration of an epithelial antigen in colon by means of fluorescent antibodies from children with ulcerative colitis. J. exp. Med., 115, 13-27.","journal-title":"J. exp. Med"},{"key":"ref_2","first-page":"181","article-title":"Quantitative assay of the lytic action of immune lymphoid cells on \"\"Cr-labelled allogeneic target cells in vitro: inhibition by isoantibody and by drugs","volume":"14","author":"Brunner, K.T.; Mauel, J.; Cerottini, J.C.; Chapuis, B.","year":"1968","unstructured":"Brunner, K. T., Mauel, J., Cerottini, J. C., and Chapuis, B. (1968). Quantitative assay of the lytic action of immune lymphoid cells on \"\"Cr-labelled allogeneic target cells in vitro: inhibition by isoantibody and by drugs. Immunology, 14, 181-196.","journal-title":"Immunology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/bmj.1.5175.764","article-title":"Recurrent Mikulicz's aphthae treated with topical hydrocortisone hemisuccinate sodium","volume":"1","author":"Cooke, B.E.D.; Armitage, P.","year":"1960","unstructured":"Cooke, B. E. D., and Armitage, P. (1960). Recurrent Mikulicz's aphthae treated with topical hydrocortisone hemisuccinate sodium. Brit. med. J., 1, 764-770.","journal-title":"Brit. med. J"},{"key":"ref_4","first-page":"709","article-title":"Recurrent aphthous ulceration: effect of sera and peripheral blood lymphocytes upon oral epithelial tissue culture cells","volume":"17","author":"Dolby, A.E.","year":"1969","unstructured":"Dolby, A. E. (1969). Recurrent aphthous ulceration: effect of sera and peripheral blood lymphocytes upon oral epithelial tissue culture cells. Immunology, 17, 709-714.","journal-title":"Immunology"},{"key":"ref_5","first-page":"681","article-title":"Mikulicz's recurrent oral aphthae: the effect of anti-lymphocyte serum upon the in vitro cytotoxicity of lymphocytes from patients for oral epithelial cells","volume":"7","author":"Dolby, A.E.","year":"1970","unstructured":"Dolby, A. E. (1970). Mikulicz's recurrent oral aphthae: the effect of anti-lymphocyte serum upon the in vitro cytotoxicity of lymphocytes from patients for oral epithelial cells. Clin. exp. Immunol., 7, 681-686.","journal-title":"Clin. exp. Immunol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/224038a0","article-title":"Lymphokines': Nonantibody mediators of cellular immunity generated by lymphocyte activations","volume":"224","author":"Dumonde, D.C.; Wolstencroft, R.A.; Panayi, G.S.; Matthew, M.; Morley, J.; Howson, W.T.","year":"1969","unstructured":"Dumonde, D. C., Wolstencroft, R. A., Panayi, G. S., Matthew, M., Morley, J., and Howson, W. T. (1969). Lymphokines': Nonantibody mediators of cellular immunity generated by lymphocyte activations. 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Ass., 196, 637-644.","journal-title":"J. Amer. med. Ass"},{"key":"ref_9","first-page":"525","article-title":"Quantitative studies on phytohaemagglutinin-induced cytotoxicity by human lymphocytes against homologous cells in tissue culture","volume":"12","author":"Holm, G.; Perlmann, P.","year":"1967","unstructured":"Holm, G., and Perlmann, P. (1967). Quantitative studies on phytohaemagglutinin-induced cytotoxicity by human lymphocytes against homologous cells in tissue culture. Immunology, 12, 525-536.","journal-title":"Immunology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1177\/003591576505800628","article-title":"'Aphthous' and herpetic lesions of the oral mucosa","volume":"58","author":"Kramer, I.R.H.","year":"1965","unstructured":"Kramer, I. R. H. (1965). 'Aphthous' and herpetic lesions of the oral mucosa. Proc. roy. Soc. Med., 58, 458-462.","journal-title":"Proc. roy. Soc. 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