{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:44:51Z","timestamp":1768895091999,"version":"3.49.0"},"reference-count":18,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1973,1]]},"abstract":"<jats:p>Some patients with the Zollinger-Ellison syndrome appear to have hypergastrinaemia and hyperplasia of the antral G cells but no tumour. This subgroup has been classified as Zollinger-Ellison syndrome type 1. We have treated such a patient by vagotomy and antrectomy, the fasting plasma gastrin and acid secretion subsequently returning to normal.<\/jats:p>\n                  <jats:p>A 17-year-old male had a four-year history of duodenal ulcer. Gastric secretion tests showed acid hypersecretion. Fasting plasma gastrin was 8350 pg\/ml (normal 50-170 pg\/ml). At laparotomy duodenal ulceration was confirmed but no pancreatic or other tumours were found. Truncal vagotomy and antrectomy was performed with distal pancreatectomy. Immunofluorescent staining showed hyperplasia of G cells in the resected antrum but a normal pancreas and duodenum.<\/jats:p>\n                  <jats:p>Six months after operation he was symptom free and acid secretion was reduced by 92%. The fasting plasma gastrin at two months was &lt;50 pg\/ml.<\/jats:p>\n                  <jats:p>These findings suggest that type 1 Zollinger-Ellison syndrome may be a clinical entity.<\/jats:p>","DOI":"10.1136\/gut.14.1.25","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"25-29","source":"Crossref","is-referenced-by-count":48,"title":["Zollinger-Ellison syndrome type 1: clinical and pathological correlations of a case"],"prefix":"10.1136","volume":"14","author":[{"given":"D. J.","family":"Cowley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. W.","family":"Dymock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. E.","family":"Boyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Y.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. H.","family":"Stagg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Lewin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia M.","family":"Polak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. G. E.","family":"Pearse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1973,1,1]]},"reference":[{"key":"ref_1","first-page":"9","article-title":"The clinical use of gastric function tests","volume":"5","author":"Baron, J.H.","year":"1970","unstructured":"Baron, J. H. (1970). The clinical use of gastric function tests. Scand. J. Gastroent., 5, Suppl. 9-46.","journal-title":"Scand. J. Gastroent"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00304798","article-title":"Immunofluorescent localization of the gastrin-secreting G-cells in the pyloric antrum of the pig","volume":"21","author":"Bussolati, G.; Pearse, A.G.E.","year":"1970","unstructured":"Bussolati, G., and Pearse, A. G. E. (1970). Immunofluorescent localization of the gastrin-secreting G-cells in the pyloric antrum of the pig. 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Studies on antibody production."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/00000658-196809000-00015","article-title":"A gastric factor in the pathogenesis of the Zollinger-Ellison syndrome","volume":"168","author":"Friesen, S.R.","year":"1968","unstructured":"Friesen, S. R. (1968). A gastric factor in the pathogenesis of the Zollinger-Ellison syndrome. Ann. Surg., 168, 483-501.","journal-title":"Ann. Surg"},{"key":"ref_6","article-title":"Microscopic Histochemistry","author":"Gomori, G.","year":"1952","unstructured":"Gomori, G. (1952). Microscopic Histochemistry. University of Chicago Press, Chicago."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2337\/diab.20.6.389","article-title":"Cellular localization of gastrin in the human pancreas","volume":"20","author":"Greider, M.H.; McGuigan, J.E.","year":"1971","unstructured":"Greider, M. H., and McGuigan, J. E. (1971). Cellular localization of gastrin in the human pancreas. Diabetes. 20, 389-396.","journal-title":"Diabetes"},{"key":"ref_8","first-page":"243","article-title":"A silver nitrate stain for a2 cells in human pancreatic islets","volume":"73","author":"Grimelius, L.","year":"1968","unstructured":"Grimelius, L. (1968). A silver nitrate stain for a2 cells in human pancreatic islets. Acta Soc. Med. upsalien., 73, 243-270.","journal-title":"Acta Soc. Med. upsalien"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1136\/gut.12.12.959","article-title":"Serum gastrin in duodenal ulcer. Part II. Effect of insulin hyperglycaemia","volume":"12","author":"Hansky, J.; Korman, M.G.; Cowley, D.J.; Baron, J.H.","year":"1971","unstructured":"Hansky, J., Korman, M. G., Cowley, D. J., and Baron, J. H. (1971). Serum gastrin in duodenal ulcer. Part II. Effect of insulin hyperglycaemia. 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Cytochemical immunofluorescence and ultrastructural investigations on the antral G-cells in hyperparathyroidism. Virchows Arch. Abt. B. Zell. path., 9, 187-197.","journal-title":"Virchows Arch. Abt. B. Zell. path"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1136\/gut.13.7.501","article-title":"Two types of Zollinger-Ellison syndrome. Immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states","volume":"13","author":"Polak, J.M.; Stagg, B.; Pearse, A.G.E.","year":"1972","unstructured":"Polak, J. M., Stagg, B., and Pearse, A. G. E. (1972). Two types of Zollinger-Ellison syndrome. Immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. 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