{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:22:42Z","timestamp":1780392162764,"version":"3.54.1"},"reference-count":16,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1973,1]]},"abstract":"<jats:p>Seventeen patients bleeding from oesophageal varices were treated by continuous infusion of vasopressin through a catheter inserted percutaneously and positioned in the superior mesenteric artery and in two other patients catheterization proved technically impossible. Bleeding was completely controlled on only four out of 18 occasions in the 17 patients treated. In seven patients, bleeding was controlled for two or more days but then recurred although the infusion was continued with an increased dose of vasopressin. There was a high incidence of complications, including bleeding from the site of catheter insertion in the groin and septicaemias. Sengstaken balloon tamponade and oesophageal transection had to be used to control bleeding in some patients but only six out of 17 survived to leave hospital.<\/jats:p>","DOI":"10.1136\/gut.14.1.59","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"59-63","source":"Crossref","is-referenced-by-count":34,"title":["Treatment of bleeding oesophageal varices by infusion of vasopressin into the superior mesenteric artery"],"prefix":"10.1136","volume":"14","author":[{"given":"Iain M.","family":"Murray-Lyon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. N. H.","family":"Pugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. B.","family":"Nunnerley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Laws","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1973,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1148\/98.3.497","article-title":"The control of gastrointestinal hemorrhage by selective mesenteric arterial infusion of vasopressin","volume":"98","author":"Baum, S.; Nusbaum, M.","year":"1971","unstructured":"Baum, S., and Nusbaum, M. (1971). The control of gastrointestinal hemorrhage by selective mesenteric arterial infusion of vasopressin. Radiology, 98, 497-505.","journal-title":"Radiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0002-9343(71)90293-2","article-title":"Pitressin-induced myocardial injury and depression in a young woman","volume":"51","author":"Beller, B.M.; Trevino, A.; Urban, E.","year":"1971","unstructured":"Beller, B. M., Trevino, A., and Urban, E. (1971). Pitressin-induced myocardial injury and depression in a young woman. Amer. J. Med., 51, 675-679.","journal-title":"Amer. J. Med"},{"key":"ref_3","first-page":"797","article-title":"La sonde de Linton-Nachlas: sa superiorit6 sur celle de Sengstaken-Blakemore pour le tamponnement des varices oeso-gastriques chez le cirrhotique","volume":"58","author":"Bertrand, L.; Michel, H.","year":"1969","unstructured":"Bertrand, L., and Michel, H. (1969). La sonde de Linton-Nachlas: sa superiorit6 sur celle de Sengstaken-Blakemore pour le tamponnement des varices oeso-gastriques chez le cirrhotique. Arch. Mal. Appar. dig., 58, 797-816.","journal-title":"Arch. Mal. Appar. dig"},{"key":"ref_4","first-page":"868","article-title":"Intra-arterial vasopressin in the treatment of upper gastrointestinal hemorrhage","volume":"62","author":"Conn, H.O.; Ramsby, G.R.; Storer, E.H.","year":"1972","unstructured":"Conn, H. O., Ramsby, G. R., and Storer, E. H. (1972). Intra-arterial vasopressin in the treatment of upper gastrointestinal hemorrhage. Gastroenterology, 62, 868.","journal-title":"Gastroenterology"},{"key":"ref_5","first-page":"945","article-title":"The natural history of haemorrhage from oesophageal varices","volume":"1","author":"Hislop, I.G.; Waters, T.E.; Kellock, T.D.; Swynnerton, B.","year":"1966","unstructured":"Hislop, I. G., Waters, T. E., Kellock, T. D., and Swynnerton, B. (1966). The natural history of haemorrhage from oesophageal varices. Lancet, 1, 945-948.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00000658-195501000-00002","article-title":"The life history of patients with cirrhosis of the liver and bleeding esophageal varices","volume":"141","author":"Nachlas, M.M.; O'Neil, J.E.; Campbell, A.J.A.","year":"1955","unstructured":"Nachlas, M. M., O'Neil, J. E., and Campbell, A. J. A. (1955). The life history of patients with cirrhosis of the liver and bleeding esophageal varices. Ann. Surg., 141, 10-23.","journal-title":"Ann. Surg"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/00000658-196909010-00018","article-title":"Clinical experience with the diagnosis and management of gastrointestinal hemorrhage by selective mesenteric catheterization","volume":"170","author":"Nusbaum, M.; Baum, S.; Blakemore, W.S.","year":"1969","unstructured":"Nusbaum, M., Baum, S., and Blakemore, W. S. (1969). Clinical experience with the diagnosis and management of gastrointestinal hemorrhage by selective mesenteric catheterization. Ann. Surg., 170, 506-514.","journal-title":"Ann. Surg"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1001\/archsurg.1968.01340060183022","article-title":"Control of portal hypertension by selective mesenteric arterial drug infusion","volume":"97","author":"Nusbaum, M.; Baum, S.; Kuroda, K.; Blakemore, W.S.","year":"1968","unstructured":"Nusbaum, M., Baum, S., Kuroda, K., and Blakemore, W. S. (1968). Control of portal hypertension by selective mesenteric arterial drug infusion. Arch. Surg., 97, 1005-1013.","journal-title":"Arch. Surg"},{"key":"ref_9","first-page":"299","article-title":"Pharmacologic control of portal hypertension","volume":"62","author":"Nusbaum, M.Baum; S., Sakiyalek; P.; Blakemore, W.S.","year":"1967","unstructured":"Nusbaum, M. Baum, S., Sakiyalek, P., and Blakemore, W. S. (1967). Pharmacologic control of portal hypertension. Surgery, 62, 299-310.","journal-title":"Surgery"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0016-5085(19)33524-3","article-title":"Safety and effectiveness of the modified Sengstaken-Blakemore tube: a prospective study","volume":"61","author":"Pitcher, J.L.","year":"1971","unstructured":"Pitcher, J. L. (1971). Safety and effectiveness of the modified Sengstaken-Blakemore tube: a prospective study. Gastroenterology, 61, 291-298.","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00005792-194209010-00001","article-title":"The natural history of Laennec's cirrhosis of the liver. An analysis of 386 cases","volume":"21","author":"Ratnoff, 0. D.; Patek, A. J., Jr","year":"1942","unstructured":"Ratnoff, 0. D., and Patek, A. J., Jr. (1942). The natural history of Laennec's cirrhosis of the liver. An analysis of 386 cases. Medicine (Baltimore), 21, 207-268.","journal-title":"Medicine (Baltimore)"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1148\/102.2.299","article-title":"Mesenteric venous thrombosis and small-bowel infarction following infusion of vasopressin into the superior mesenteric artery","volume":"102","author":"Renert, W.A.; Button, K.F.; Fuld, S.L.; Casarella, W.J.","year":"1972","unstructured":"Renert, W. A., Button, K. F., Fuld, S. L., and Casarella, W. J. (1972). Mesenteric venous thrombosis and small-bowel infarction following infusion of vasopressin into the superior mesenteric artery. Radiology, 102, 299-302.","journal-title":"Radiology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1148\/99.1.27","article-title":"Selective arterial infusions of vasoconstrictors in acute gastro-intestinal bleeding","volume":"99","author":"Rosch, J.; Dotter, C.T.; Rose, R.W.","year":"1971","unstructured":"Rosch, J., Dotter, C. T., and Rose, R. W. (1971). Selective arterial infusions of vasoconstrictors in acute gastro-intestinal bleeding. Radiology, 99, 27-36.","journal-title":"Radiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0140-6736(60)91423-9","article-title":"The use of vasopressin (Pitressin) in the control of bleeding from oesophageal varices","volume":"2","author":"Shaldon, S.; Sherlock, S.","year":"1960","unstructured":"Shaldon, S., and Sherlock, S. (1960). The use of vasopressin (Pitressin) in the control of bleeding from oesophageal varices. Lancet, 2, 222-225.","journal-title":"Lancet"},{"key":"ref_15","first-page":"117","volume":"121","author":"Stahl, W.M.","year":"1971","unstructured":"Stahl, W. M. (1971). In discussion. Amer. J. Surg., 121, 117.","journal-title":"In discussion. Amer. J. Surg"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0016-5085(61)80017-6","article-title":"Spontaneous colon bacillus bacteremnia in Laennec's cirrhosis","volume":"40","author":"Tisdale, W.A.","year":"1961","unstructured":"Tisdale, W. A. (1961). Spontaneous colon bacillus bacteremnia in Laennec's cirrhosis. Gastroenterology, 40, 141-148.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.14.1.59","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:06:57Z","timestamp":1765073217000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.14.1.59"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,1]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1973,1,1]]},"published-print":{"date-parts":[[1973,1]]}},"alternative-id":["10.1136\/gut.14.1.59"],"URL":"https:\/\/doi.org\/10.1136\/gut.14.1.59","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,1]]}}}