{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T19:34:43Z","timestamp":1765654483815,"version":"3.48.0"},"reference-count":32,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1973,11]]},"abstract":"<jats:p>\n                    A new technique for measuring changes in the architecture of the small intestinal mucosa is described using a modification of the technique of television image analysis to measure the areas occupied by the surface and crypt epithelium in proximal jejunal biopsies. The ratios of these two areas to each other were then calculated. In 12 control mucosae, the mean ratio (\u00b1SD) was 2\u00b727 \u00b1 0\u00b741. In 12 untreated flat mucosae, by contrast, the mean ratio was only 0\u00b724 \u00b1 0\u00b707. This ten-fold difference, which was highly significant (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b7001), was greater than that for any similar measurements previously reported. This technique is intended for the measurement of changes in the mucosa too small for existing techniques to detect reliably rather than for the diagnosis of coeliac disease.\n                  <\/jats:p>","DOI":"10.1136\/gut.14.11.905","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"905-909","source":"Crossref","is-referenced-by-count":11,"title":["A new technique for examining intestinal biopsies"],"prefix":"10.1136","volume":"14","author":[{"given":"B. L.","family":"Chapman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Paice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. F.","family":"Coghill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1973,11,1]]},"reference":[{"key":"ref_1","first-page":"404","article-title":"Measurement and features of normal jejunal mucosa by peroral biopsy","author":"Astaldi, G.; Conrad, M.; Ratto, L.; Costa, G.","year":"1965","unstructured":"Astaldi, G., Conrad, M., Ratto, L., and Costa, G. (1965). Measurement and features of normal jejunal mucosa by peroral biopsy. Pamninerva med., (English edition), 7, 404-408.","journal-title":"Pamninerva med"},{"key":"ref_2","first-page":"1344","article-title":"Adult celiac disease: rapid sequential changes in jejunal mucosa with alterations of dietary gluten","volume":"41","author":"Bayless, T.M.; Yardley, J.H.; Norton, J.H.; Hendrix, T.R.","year":"1962","unstructured":"Bayless, T. M., Yardley, J. H., Norton, J. H., and Hendrix, T. R. (1962). Adult celiac disease: rapid sequential changes in jejunal mucosa with alterations of dietary gluten. (Abstr.) J. clin. Invest., 41, 1344.","journal-title":"(Abstr.) J. clin. Invest"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.7326\/0003-4819-60-4-581","article-title":"Adult celiac disease: histologic results of long-term low gluten diet","volume":"60","author":"Bolt, R.J.; Parrish, J.A.; French, A.B.; Pollard, H.M.","year":"1964","unstructured":"Bolt, R. J., Parrish, J. A., French, A. B., and Pollard, H. M. (1964). Adult celiac disease: histologic results of long-term low gluten diet. Ann. intern. Med., 60, 581-586.","journal-title":"Ann. intern. Med"},{"key":"ref_4","first-page":"2","article-title":"Dissecting microscope appearances of intestinal mucosa","volume-title":"Intestinal Biopsy (Ciba Foundation Study Group","volume":"14","author":"Booth, C.C.; Stewart, J.S.; Holmes, R.; Brackenbury, W.","year":"1962","unstructured":"Booth, C. C., Stewart, J. S., Holmes, R., and Brackenbury, W. (1962). Dissecting microscope appearances of intestinal mucosa. In Intestinal Biopsy (Ciba Foundation Study Group, No. 14), edited by G. E. W. Wolstenholme and M. P. Cameron, pp. 2-23. Churchill, London."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.7326\/0003-4819-48-1-8","article-title":"Jejunal biopsies in sprue","volume":"48","author":"Butterworth, C. E. Jr.; Perez-Santiago, E","year":"1958","unstructured":"Butterworth, C. E. Jr., and Perez-Santiago, E. (1958). Jejunal biopsies in sprue. Ann. intern. Med., 48, 8-29.","journal-title":"Ann. intern. Med"},{"key":"ref_6","first-page":"125","article-title":"Duodenojejunal biopsy in the investigation of children with coeliac disease","volume":"31","author":"Cameron, A.H.; Astley, R.; Hallowell, M.; Rawson, A.B.; Miller, C.G.; French, J.M.; Hubble, D.V.","year":"1962","unstructured":"Cameron, A. H., Astley, R., Hallowell, M., Rawson, A. B., Miller, C. G., French, J. M., and Hubble, D. V. (1962). Duodenojejunal biopsy in the investigation of children with coeliac disease. Quart. J. Med., 31, 125-140.","journal-title":"Quart. J. Med"},{"key":"ref_7","first-page":"203","article-title":"Histopathological changes in the upper jejunum in tropical malabsorption syndrome studied by transoral biopsy","volume":"4","author":"Chacko, C.J.G.; Job, C.K.; Johnson, S.; Baker, S.J.","year":"1961","unstructured":"Chacko, C. J. G., Job, C. K., Johnson, S., and Baker, S. J. (1961). Histopathological changes in the upper jejunum in tropical malabsorption syndrome studied by transoral biopsy. Indian J. Path. Bact., 4, 203-213.","journal-title":"Indian J. Path. Bact"},{"key":"ref_8","article-title":"In preparation","author":"Coyne, M.B.","year":"1973","unstructured":"Coyne, M. B. (1973). In preparation."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/BF02231100","article-title":"Intraluminal biopsy of the small intestine: the intestinal biopsy capsule","volume":"2","author":"Crosby, W.H.; Kugler, H.W.","year":"1957","unstructured":"Crosby, W. H., and Kugler, H. W. (1957). Intraluminal biopsy of the small intestine: the intestinal biopsy capsule. Amer. J. dig. Dis., 2, 236-241.","journal-title":"Amer. J. dig. 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Med"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1136\/gut.13.7.501","article-title":"Two types of Zollinger-Ellison syndrome; immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states","volume":"13","author":"Polak, J.M.; Stagg, B.; Pearse, A.G.E.","year":"1972","unstructured":"Polak, J. M., Stagg, B., and Pearse, A. G. E. (1972). Two types of Zollinger-Ellison syndrome; immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. Gut, 13, 501-512.","journal-title":"Gut"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/gut.11.7.567","article-title":"The effect on jejunal mucosa of withdrawing and adding dietary gluten in cases of idiopathic steatorrhoea","volume":"11","author":"Pollock, D.J.; Nagle, R.E.; Jeejeebhoy, K.N.; Coghill, N.F.","year":"1970","unstructured":"Pollock, D. J., Nagle, R. E., Jeejeebhoy, K. N., and Coghill, N. F. (1970). The effect on jejunal mucosa of withdrawing and adding dietary gluten in cases of idiopathic steatorrhoea. Gut, 11, 567-575.","journal-title":"Gut"},{"key":"ref_21","first-page":"28","article-title":"Studies of celiac disease. I. The apparent identical and specific nature of the duodenal and proximal jejunal lesion in celiac disease and idiopathic sprue","volume":"38","author":"Rubin, C.E.; Brandborg, L.L.; Phelps, P.C.; Taylor, Jr, H.C.","year":"1960","unstructured":"Rubin, C. E., Brandborg, L. L., Phelps, P. C., and Taylor, H. C., Jr. (1960). Studies of celiac disease. I. The apparent identical and specific nature of the duodenal and proximal jejunal lesion in celiac disease and idiopathic sprue. 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EDMONDS AND DIANA PILCHER","key":"ref_32"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.14.11.905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T19:30:17Z","timestamp":1765654217000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.14.11.905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,11]]},"references-count":32,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1973,11,1]]},"published-print":{"date-parts":[[1973,11]]}},"alternative-id":["10.1136\/gut.14.11.905"],"URL":"https:\/\/doi.org\/10.1136\/gut.14.11.905","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1973,11]]}}}