{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:12:52Z","timestamp":1761559972792,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1973,12]]},"abstract":"<jats:p>Liver biopsy was performed in 38 patients with fulminant hepatitis and coma and repeated in 22. Stereological estimation of hepatocyte volume was correlated with levels of clotting factors.<\/jats:p>\n               <jats:p>Early liver biopsy allowed prognosis in 55% of the cases. All patients with a hepatocyte volume of &lt;35% and thromboplastin time \u226410% died; all patients but two with hepatocyte volume \u226535% and thromboplastin time &gt;10% recovered consciousness (n = 9) or at least showed evidence of marked liver regeneration (n = 2).<\/jats:p>\n               <jats:p>On serial liver biopsy a significant increase in hepatocyte volume and clotting factors was only observed in patients who recovered consciousness. The estimated liver cell mass after regeneration in patients who recovered consciousness was \u226545% and &lt;45% in the patients who did not.<\/jats:p>","DOI":"10.1136\/gut.14.12.927","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"927-933","source":"Crossref","is-referenced-by-count":78,"title":["Liver biopsy and prognosis in acute liver failure"],"prefix":"10.1136","volume":"14","author":[{"given":"J.","family":"Scotto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Opolon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"\u00c9t\u00e9v\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Vergoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Caroli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1973,12,1]]},"reference":[{"key":"ref_1","first-page":"463466","article-title":"El6ments du pronostic au cours des comas par atrophie h6patique aigue","volume":"79","author":"Caroli, J.; Opolon, P.; Scotto, J.; Hadchouel, P.; Thomas, M.; Lageron, A.","year":"1971","unstructured":"Caroli, J., Opolon, P., Scotto, J., Hadchouel, P., Thomas, M., and Lageron, A. (1971). El6ments du pronostic au cours des comas par atrophie h6patique aigue. Presse mid., 79, 463466.","journal-title":"Presse mid"},{"key":"ref_2","first-page":"47","article-title":"Method for the quantitative morphologic analysis of tissues","volume":"4","author":"Chalkley, H.W.","year":"1943","unstructured":"Chalkley, H. W. (1943). Method for the quantitative morphologic analysis of tissues. J. nat. Cancer Inst., 4, 47.","journal-title":"J. nat. Cancer Inst"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1126\/science.110.2856.295","article-title":"A method for estimating volume surface ratios","volume":"110","author":"Chalkley, H.W.; Cornfield, J.; Park, H.","year":"1949","unstructured":"Chalkley, H. W., Cornfield, J., and Park, H. (1949). A method for estimating volume surface ratios. Science, 110, 295.","journal-title":"Science"},{"key":"ref_4","first-page":"1716","article-title":"Blutgerinnungs-faktoren als Index fiur den Schweregrad einer akuter Hepatitis","volume":"97","author":"Colombi, A.; Tholen, H.; Engelhart, G.; Duckert, F.; Hecht, Y.; Koller, F.","year":"1967","unstructured":"Colombi, A., Tholen, H., Engelhart, G., Duckert, F., Hecht, Y., and Koller, F. (1967). Blutgerinnungs-faktoren als Index fiur den Schweregrad einer akuter Hepatitis. Schweiz. med. Wscht, 97, 1716-1721","journal-title":"Schweiz. med. Wscht"},{"key":"ref_5","first-page":"133","article-title":"Les alt6rations histologiques des h6patites graves et leur 6volution. A propos de 45 observations suivies par biopsies","volume":"8","author":"Paliard, P.; Patricot, F.; Grimand, J.A.","year":"1972","unstructured":"Paliard, P., Patricot, F., and Grimand, J. A. (1972). Les alt6rations histologiques des h6patites graves et leur 6volution. A propos de 45 observations suivies par biopsies. Ann. Gastroent. Hefpat., 8, 133-150.","journal-title":"Ann. Gastroent. Hefpat"},{"key":"ref_6","first-page":"1","article-title":"Ammoni6mie et 6quilibre acido-basique au cours de l'atrophie aigu6 du foie","volume":"121","author":"Opolon, P.; Hadchouel, P.; Del Corso, A.; Caroli, J.","year":"1970","unstructured":"Opolon, P., Hadchouel, P., Del Corso, A., and Caroli, J. (1970). Ammoni6mie et 6quilibre acido-basique au cours de l'atrophie aigu6 du foie. Ann. Mid. interne, 121, 1-15.","journal-title":"Ann. Mid. interne"},{"key":"ref_7","first-page":"61","article-title":"Hepatite aigue: application d'une m6thode st6r6ologique en microscopie optique. Sp6culations pronostiques","volume":"45","author":"Scotto, J.; Theodoropoulos, G.; Lageron, A.","year":"1970","unstructured":"Scotto, J., Theodoropoulos, G., and Lageron, A. (1970). Hepatite aigue: application d'une m6thode st6r6ologique en microscopie optique. Sp6culations pronostiques. Rev. med.-chir. Mal. Foie, 45, 61-64.","journal-title":"Rev. med.-chir. Mal. Foie"},{"key":"ref_8","article-title":"Fulminant hepatic surveillance study","author":"Trey, C.","year":"1967","unstructured":"Trey, C. (1967). Fulminant hepatic surveillance study. (First progress report)."},{"issue":"92","key":"ref_9","first-page":"118","article-title":"Determination of the hepatic elimination capacity (Lm) of galactose by single injection. Scand","volume":"18","author":"Tygstrup, N.","year":"1966","unstructured":"Tygstrup, N. (1966). Determination of the hepatic elimination capacity (Lm) of galactose by single injection. Scand. J. clin. Lab Invest., 18, Suppl. 92, 118-125.","journal-title":"J. clin. Lab Invest"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.14.12.927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:21:41Z","timestamp":1757312501000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.14.12.927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,12]]},"references-count":9,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1973,12,1]]},"published-print":{"date-parts":[[1973,12]]}},"alternative-id":["10.1136\/gut.14.12.927"],"URL":"https:\/\/doi.org\/10.1136\/gut.14.12.927","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1973,12]]}}}