{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:17:27Z","timestamp":1764688647473,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1973,8]]},"abstract":"<jats:p>A hyperproductive mucosal state in gluten-sensitive enteropathy has been proposed on the basis of an elevated mitotic index, but this parameter is dependent on the mitotic duration when used as an index of proliferative status. The mitotic duration was therefore measured in two control patients with normal villous mucosae and in two patients with the flat avillous mucosa of untreated gluten-sensitive enteropathy, using two different stathmokinetic techniques with vincristine. No significant difference in mitotic duration was found but values obtained for cell cycle time showed a halving in the flat mucosae. An increased rate of cell production in the small bowel mucosa of untreated gluten-sensitive enteropathy is thus confirmed.<\/jats:p>","DOI":"10.1136\/gut.14.8.603","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"603-606","source":"Crossref","is-referenced-by-count":50,"title":["The cell cycle time in the flat (avillous) mucosa of the human small intestine"],"prefix":"10.1136","volume":"14","author":[{"given":"Nicholas","family":"Wright","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Morley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Appleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Marks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1973,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/0014-4827(72)90406-5","article-title":"On correcting the error due to metaphase degeneration in stathmokinetic studies","volume":"74","author":"Aherne, W.A.; Camplejohn, R.S.","year":"1972","unstructured":"Aherne, W. A., and Camplejohn, R. S. (1972). On correcting the error due to metaphase degeneration in stathmokinetic studies. Exp. Cell Res., 74, 496-502.","journal-title":"Exp. Cell Res"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"725731","DOI":"10.1136\/bmj.3.5725.725","article-title":"Enterocyte in coeliac disease","volume":"3","author":"Booth, C.C.","year":"1970","unstructured":"Booth, C. C. (1970). Enterocyte in coeliac disease. Brit. med. J., 3, 725731.","journal-title":"Brit. med. J"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0140-6736(68)90354-1","article-title":"Small-bowel cellloss and weight-loss in the coeliac syndrome","volume":"2","author":"Croft, D.N.; Loehry, C.A.; Creamer, B.","year":"1968","unstructured":"Croft, D. N., Loehry, C. A., and Creamer, B. (1968). Small-bowel cellloss and weight-loss in the coeliac syndrome. Lancet, 2, 68-70.","journal-title":"Lancet"},{"key":"ref_4","article-title":"Cell cycle of cancer cells","volume-title":"man. In The Cell Cycle and","author":"Gavast; F.; Pileri, A.","year":"1971","unstructured":"Gavast,, F., and Pileri, A. (1971). Cell cycle of cancer cells in man. In The Cell Cycle and Cancer, edited by R. Baserga. Dekker, New York."},{"key":"ref_5","article-title":"Cell proliferation kinetics in the gastrointestinal tract of[man","author":"Lipkin, M.; Bell, B.; Sherlock, P.","year":"1963","unstructured":"Lipkin, M., Bell, B., and Sherlock, P. (1963). Cell proliferation kinetics in the gastrointestinal tract of[man."},{"key":"ref_6","first-page":"\"767","article-title":"Cell renewal in colon and rectum","volume":"42","author":"Padykula, H.A.; Strauss, E.W.; Ladman, A.J.; Gardner, F.H.","year":"1961","unstructured":"Cell renewal in colon and rectum. J. clin. Invest., 42, 767-776. Padykula, H. A., Strauss, E. W., Ladman, A. J., and Gardner, F. H. (1961). 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(1970). Epithelial-cell renewal in cultured duodenal biopsies in coeliac sprue. New Engl. J. Med., 283, 1245-1250.","journal-title":"New Engl. J. Med"},{"key":"ref_9","first-page":"60","volume-title":"Proliferative abnormalities in the gastro-intestinal tract. In Modern Trends in Gastroenterology","volume":"4","author":"Winawer, S.J.; Lipkin, M.","year":"1970","unstructured":"Winawer, S. J., and Lipkin, M. (1970). Proliferative abnormalities in the gastro-intestinal tract. In Modern Trends in Gastroenterology, vol. 4, pp. 60-72, edited by W. I. Card and B. Creamer. Butterworths, London."},{"key":"ref_10","first-page":"351","article-title":"Variation in mitotic duration in the crypts of Leiberkuhn of the rat: a cytokinetic study using vincristine","volume":"5","author":"Wright, N.A.; Morley, A.R.; Appleton, D.R.","year":"1972","unstructured":"Wright, N. A., Morley, A. R., and Appleton, D. R. (1972). Variation in mitotic duration in the crypts of Leiberkuhn of the rat: a cytokinetic study using vincristine. Cell Tiss. Kinet., 5, 351-364.","journal-title":"Cell Tiss. Kinet"},{"key":"ref_11","first-page":"11731179","article-title":"Cell kinetics in flat (avillous) mucosa of the human small intestine","volume":"14","author":"Wright, N.A.; Watson, A.J.; Morley, A.R.; Appleton, D.; Marks, J.","year":"1973","unstructured":"Wright, N. A., Watson, A. J., Morley, A. R., Appleton, D., and Marks, J. (1973). Cell kinetics in flat (avillous) mucosa of the human small intestine. Gut, 14, Yardley, J. H., Bayless, T. M., Norton, J. H., and Hendrix, T. R. (1962), Celiac disease: a study of the jejunal epithelium before and after a gluten-free diet. New Engl. J. Med., 267, 11731179.","journal-title":"Gut; Celiac disease: a study of the jejunal epithelium before and after a gluten-free diet"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.14.8.603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T20:20:50Z","timestamp":1757276450000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.14.8.603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,8]]},"references-count":11,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1973,8,1]]},"published-print":{"date-parts":[[1973,8]]}},"alternative-id":["10.1136\/gut.14.8.603"],"URL":"https:\/\/doi.org\/10.1136\/gut.14.8.603","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1973,8]]}}}