{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:22:47Z","timestamp":1771629767026,"version":"3.50.1"},"reference-count":12,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1974,11]]},"abstract":"<jats:p>Oesophageal acid clearing has been measured by counting the number of swallows needed to raise the lower oesophageal pH from 1\u00b75 to 5\u00b70 after instilling 15 ml 0\u00b71 N hydrochloric acid. Normal subjects all had a result less than 12, as did asymptomatic patients with hiatal hernias. Patients with symptomatic gastrooesophageal reflux tended to have abnormal acid clearance, as did those with oesophageal motility disorders. Acid clearance correlated well with the mean duration of spontaneous episodes of acid reflux during 15-hour continuous recordings of lower oesophageal pH.<\/jats:p>\n                  <jats:p>Abnormal acid clearance was improved by raising the bedhead, by medical treatment for oesophagitis, and by metoclopramide.<\/jats:p>\n                  <jats:p>We conclude that abnormal acid clearing may result from disturbed oesophageal motility and render patients with these disorders susceptible to reflux oesophagitis. However, it also seems that gastrooesophageal reflux may lead to impaired acid clearance, both by creating abnormal motility and by effects on the oesophageal wall, and thus lead to a `vicious-spiral' oesophagitis. In treating gastrooesophageal reflux, attention must be paid to improving acid clearance.<\/jats:p>","DOI":"10.1136\/gut.15.11.852","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"852-857","source":"Crossref","is-referenced-by-count":145,"title":["Oesophageal acid clearing: One factor in the production of reflux oesophagitis"],"prefix":"10.1136","volume":"15","author":[{"given":"C.","family":"Stanciu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/bjs.18004821212","article-title":"Problems of achalasia","volume":"48","author":"Barlow, D.","year":"1961","unstructured":"Barlow, D. (1961). Problems of achalasia. Brit. J. Surg., 48, 642-645.","journal-title":"Brit. J. Surg"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1001\/archsurg.1968.01330230039006","article-title":"Acid clearing from the distal esophagus","volume":"96","author":"Booth, D.J.; Kemmerer, W.T.; Skinner, D.B.","year":"1968","unstructured":"Booth, D. J., Kemmerer, W. T., and Skinner, D. B. (1968). Acid clearing from the distal esophagus. Arch. Surg., 96, 731-734.","journal-title":"Arch. Surg"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0140-6736(55)90108-2","article-title":"Oesophageal reflux","volume":"1","author":"Creamer, B.","year":"1955","unstructured":"Creamer, B. (1955). Oesophageal reflux. Lancet, 1, 279-281.","journal-title":"Lancet"},{"key":"ref_4","first-page":"6","article-title":"Reflux after cardiomyotomy","author":"Ellis, F.; Cole, F.L.","year":"1965","unstructured":"Ellis, F., and Cole, F. L. (1965). Reflux after cardiomyotomy. Gut, 6,80-84."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1172\/JCI104335","article-title":"Heartburn in late pregnancy: manometric studies of esophageal motor function","volume":"40","author":"Nagler, R.; Spiro, H.M.","year":"1961","unstructured":"Nagler, R., and Spiro, H. M. (1961). Heartburn in late pregnancy: manometric studies of esophageal motor function. J. clin. Invest., 40, 954-970.","journal-title":"J. clin. Invest"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/gut.11.8.659","article-title":"Investigation of gastro-oesophageal reflux in various positions with a two-lumen pH electrode","volume":"11","author":"Pattrick, F.G.","year":"1970","unstructured":"Pattrick, F. G. (1970). Investigation of gastro-oesophageal reflux in various positions with a two-lumen pH electrode. Gut, 11, 659-667.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1172\/JCI104760","article-title":"Esophageal motor abnormalities induced by acid perfusion in patients with heartburn","volume":"42","author":"Siegel, C.I.; Hendrix, T.R.","year":"1963","unstructured":"Siegel, C. I., and Hendrix, T. R. (1963). Esophageal motor abnormalities induced by acid perfusion in patients with heartburn. J. clin. Invest., 42, 686-695.","journal-title":"J. clin. Invest"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/bjs.1800561211","article-title":"Prolonged pH recoiding in the study of gastrooesophageal reflux","volume":"56","author":"Spencer, J.","year":"1969","unstructured":"Spencer, J. (1969). Prolonged pH recoiding in the study of gastrooesophageal reflux. Brit. J. Surg., 56, 912-914.","journal-title":"Brit. J. Surg"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1136\/gut.14.4.275","article-title":"Metoclopramide in gastrooesophageal reflux","volume":"14","author":"Stanciu, C.; Bennett, J.R.","year":"1973","unstructured":"Stanciu, C., and Bennett, J. R. (1973). Metoclopramide in gastrooesophageal reflux. Gut, 14, 275-279.","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0016-5085(60)80053-4","article-title":"Esophageal acid perfusion test and a gastroesophageal reflux test in patients with esophagitis","volume":"38","author":"Tuttle, S.G.; Bettarello, A.; Grossman, M.I.","year":"1960","unstructured":"Tuttle, S. G., Bettarello, A., and Grossman, M. I. (1960). Esophageal acid perfusion test and a gastroesophageal reflux test in patients with esophagitis. Gastroenterology, 38, 861-872.","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1136\/thx.25.5.568","article-title":"The assessment of oesophagitis in hiatus hernia patients","volume":"25","author":"Ward, A.S.; Wright, D.H.; Collis, J.L.","year":"1970","unstructured":"Ward, A. S., Wright, D. H., and Collis, J. L. (1970). The assessment of oesophagitis in hiatus hernia patients. Thorax, 25, 568-572.","journal-title":"Thorax"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/thx.25.4.459","article-title":"Response of the gullet to gastric reflux in patients with hiatus hernia and oesophagitis","volume":"25","author":"Woodward, D.A.K.","year":"1970","unstructured":"Woodward, D. A. K. (1970). Response of the gullet to gastric reflux in patients with hiatus hernia and oesophagitis. Thorax, 25, 459-464.","journal-title":"Thorax"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.15.11.852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:26:07Z","timestamp":1765603567000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.15.11.852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,11]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1974,11,1]]},"published-print":{"date-parts":[[1974,11]]}},"alternative-id":["10.1136\/gut.15.11.852"],"URL":"https:\/\/doi.org\/10.1136\/gut.15.11.852","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,11]]}}}