{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:30:03Z","timestamp":1758123003506,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1974,11]]},"abstract":"<jats:p>A previously described technique for measuring changes in the architecture of the small intestinal mucosa was used to measure the long-term response in six patients with adult coeliac disease to treatment with a gluten-free diet. All had flat or flat-with-mosaic jejunal mucosae before treatment and were subsequently believed to keep strictly to a gluten-free diet. They were followed for between four and 14 months from the start of treatment. The ratio of the area of surface epithelium to that of crypt epithelium (`area ratio') invariably increased following gluten withdrawal, but did not begin to do so until after several weeks of treatment. No patient attained complete histological normality within the limited period of observation, which was never more than 14 months. In one of the three patients followed for a year or more the area ratio increased to within the control range, and in two of these three the ratio was about 10 times the pretreatment ratio. There was a highly significant linear correlation between area ratio and time on the diet (r = 0.775, <jats:sc>p<\/jats:sc> &lt; 0.005).<\/jats:p>\n               <jats:p>The surface cell height measurements for these patients, by contrast, rose steeply and almost invariably during the first few weeks of treatment, but after that they fluctuated without further significant change. It is suggested that the two methods of measurement were complementary to each other, surface cell height being useful while the patient was in hospital on a rigidly strict diet, and the area ratio after return home, when minor dietary lapses were almost invariable.<\/jats:p>","DOI":"10.1136\/gut.15.11.870","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"870-874","source":"Crossref","is-referenced-by-count":11,"title":["Measuring the response of the jejunal mucosa in adult coeliac disease to treatment with a gluten-free diet"],"prefix":"10.1136","volume":"15","author":[{"given":"B. L.","family":"Chapman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Paice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. F.","family":"Coghill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,11,1]]},"reference":[{"key":"ref_1","series-title":"Coeliac Disease: Proceedings of an International Conference held at the Royal Postgraduate Medical School","first-page":"76","article-title":"Morphologic and functional effects of gluten feeding on jejunal mucosa in coeliac disease","author":"Bayless, T.M.; Rubin, C.E.; Topping, T.M.; Yardley, J.H.; Hendrix, T.R.","year":"1970","unstructured":"Bayless, T. M., Rubin, C. E., Topping, T. M., Yardley, J. H., and Hendrix, T. R. (1970). Morphologic and functional effects of gluten feeding on jejunal mucosa in coeliac disease. In Coeliac Disease: Proceedings of an International Conference held at the Royal Postgraduate Medical School, London, 1969, edited by C. C. Booth and R. H. Dowling, pp. 76-90. Churchill Livingstone, Edinburgh and London."},{"key":"ref_2","first-page":"1344","article-title":"Adult celiac disease: rapid sequential changes in jejunal mucosa with alterations of dietary gluten","volume":"41","author":"Bayless, T.M.; Yardley, J.H.; Norton, J.H.; Hendrix, T.R.","year":"1962","unstructured":"Bayless, T. M., Yardley, J. H., Norton, J. H., and Hendrix, T. R. (1962). Adult celiac disease: rapid sequential changes in jejunal mucosa with alterations of dietary gluten. J. clin. Invest., 41, 1344.","journal-title":"J. clin. Invest"},{"key":"ref_3","first-page":"2","article-title":"Dissecting microscope appearances of intestinal mucosa","volume-title":"Intestinal Biopsy (Ciba Foundation Study Group","volume":"14","author":"Booth, C.C.; Stewart, J.S.; Holmes, R.; Brackenbury, W.","year":"1962","unstructured":"Booth, C. C., Stewart, J. S., Holmes, R., and Brackenbury, W. (1962). Dissecting microscope appearances of intestinal mucosa. In Intestinal Biopsy (Ciba Foundation Study Group No. 14), edited by G. E. W. Wolstenholme and M. P. Cameron, pp. 2-23. Churchill, London."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1136\/bmj.4.5573.222","article-title":"A case of Crohn's disease in a patient with treated adult coeliac disease","volume":"4","author":"Booth, C.C.; Stewart, J.S.; Olsen, E.","year":"1967","unstructured":"Booth, C. C., Stewart, J. S., Olsen, E., et al (1967). A case of Crohn's disease in a patient with treated adult coeliac disease. (Clinicopathological Conference). Brit. med. J., 4, 222-226.","journal-title":"(Clinicopathological Conference). Brit. med. J"},{"key":"ref_5","first-page":"47","article-title":"Method for the quantitative morphologic analysis of tissues","volume":"4","author":"Chalkley, H.W.","year":"1943","unstructured":"Chalkley, H. W. (1943). Method for the quantitative morphologic analysis of tissues. J. nat. Cancer Inst., 4, 47-53.","journal-title":"J. nat. Cancer Inst"},{"key":"ref_6","series-title":"the Proceedings of the British Society of Gastroenterology. Gut","first-page":"846","article-title":"A new technique for examining intestinal biopsies. Abstract","volume":"13","author":"Chapman, B.L.; Henry, K.; Paice, F.; Stewart, J.S.; Coghill, N.F.","year":"1972","unstructured":"Chapman, B. L., Henry, K., Paice, F., Stewart, J. S., and Coghill, N. F. (1972). A new technique for examining intestinal biopsies. Abstract in the Proceedings of the British Society of Gastroenterology. Gut, 13, 846."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/gut.14.11.905","article-title":"A new technique for examining intestinal biopsies","volume":"14","author":"Chapman, B.L.; Henry, K.; Paice, F.; Stewart, J.S.; Coghill, N.F.","year":"1973","unstructured":"Chapman, B. L., Henry, K., Paice, F., Stewart, J. S., and Coghill, N. F. (1973). A new technique for examining intestinal biopsies. Gut, 14, 905-909.","journal-title":"Gut"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/00359157730661P113","article-title":"Adult coeliac disease and multiple small bowel diverticula","volume":"66","author":"Chapman, B.L.; Stewart, J.S.","year":"1973","unstructured":"Chapman, B. L., and Stewart, J. S. (1973). Adult coeliac disease and multiple small bowel diverticula. Proc. roy. Soc. Med., 66, 11-12.","journal-title":"Proc. roy. Soc. Med"},{"key":"ref_9","first-page":"378","article-title":"Proc6d6 m6canique pour determiner la composition des roches","volume":"13","author":"Delesse, M.","year":"1848","unstructured":"Delesse, M. (1848). Proc6d6 m6canique pour determiner la composition des roches. Ann. Mines (Paris), 13, 378-388.","journal-title":"Ann. Mines (Paris)"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0016-5085(19)35791-9","article-title":"Duodenal and jejunal biopsies","volume":"33","author":"Doniach, I.; Shiner, M.","year":"1957","unstructured":"Doniach, I., and Shiner, M. (1957). Duodenal and jejunal biopsies. It. Histology. Gastroenterology, 33, 71-86.","journal-title":"It. Histology. Gastroenterology"},{"key":"ref_11","article-title":"Counting techniques in morbid anatomy","volume-title":"Proc","author":"Dunnill, M.S.","year":"1972","unstructured":"Dunnill, M. S. (1972). Counting techniques in morbid anatomy. Proc."},{"key":"ref_12","first-page":"243246","article-title":"A method for the quantitation of small intestinal biopsy specimens","volume":"25","author":"Dunnill, M.S.; Whitehead, R.","year":"1972","unstructured":"Dunnill, M. S., and Whitehead, R. (1972). A method for the quantitation of small intestinal biopsy specimens. J. clin. Path., 25, 243246.","journal-title":"J. clin. Path"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0300-5089(21)00352-7","article-title":"Anaemia in adult coeliac disease","volume":"3","author":"Hoffbrand, A.V.","year":"1974","unstructured":"Hoffbrand, A. V. (1974). Anaemia in adult coeliac disease. Clin. Gastroent., 3, 71-89.","journal-title":"Clin. Gastroent"},{"key":"ref_14","first-page":"81","article-title":"Dissectingmicroscope appearances of jejunal biopsy specimens from patients with 'idiopathic steatorrhoea'","volume":"1","author":"Holmes, R.; Hourihane, D.O.'B.; Booth, C.C.","year":"1961","unstructured":"Holmes, R., Hourihane, D. O'B., and Booth, C. C. (1961). Dissectingmicroscope appearances of jejunal biopsy specimens from patients with 'idiopathic steatorrhoea'. Lancet, 1, 81-83.","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0002-9343(65)90158-0","article-title":"Measurements of small intestinal mucosa obtained by peroral biopsy","volume":"38","author":"Madanagopalan, N.; Shiner, M.; Rowe, B.","year":"1965","unstructured":"Madanagopalan, N., Shiner, M., and Rowe, B. (1965). Measurements of small intestinal mucosa obtained by peroral biopsy. Amer. J. Med., 38, 42-53.","journal-title":"Amer. J. Med"},{"key":"ref_16","first-page":"457","article-title":"Disaccharidase activity and jejunal morphology in coeliac disease","volume":"41","author":"Peina, A.S.; Truelove, S.C.; Whitehead, R.","year":"1972","unstructured":"Peina, A. S., Truelove, S. C., and Whitehead, R. (1972). Disaccharidase activity and jejunal morphology in coeliac disease. Quart. J. Med., n.s., 41, 457-476.","journal-title":"Quart. J. Med., n.s"},{"key":"ref_17","first-page":"567575","article-title":"The effect on jejunal mucosa of withdrawing and adding dietary gluten in cases of idiopathic steatorrhoea","volume":"11","author":"Pollock, D.J.; Nagle, R.E.; Jeejeebhoy, K.N.; Coghill, N.F.","year":"1970","unstructured":"Pollock, D. J., Nagle, R. E., Jeejeebhoy, K. N., and Coghill, N. F. (1970). The effect on jejunal mucosa of withdrawing and adding dietary gluten in cases of idiopathic steatorrhoea. Gut, 11, 567575.","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0016-5085(60)80143-6","article-title":"Histopathologic studies in steatorrhea","volume":"38","author":"Shiner, M.; Doniach, I.","year":"1960","unstructured":"Shiner, M., and Doniach, I. (1960). Histopathologic studies in steatorrhea. Gastroenterology, 38, 419-440.","journal-title":"Gastroenterology"},{"key":"ref_19","article-title":"A study of intestinal mucosal structure and absorptive function in adult coeliac disease","author":"Stewart, J.S.","year":"1970","unstructured":"Stewart, J. S. (1970). A study of intestinal mucosal structure and absorptive function in adult coeliac disease. Doctoral Thesis, University ofLondon."},{"key":"ref_20","first-page":"425","article-title":"A study of proximal and distal intestinal structure and absorptive function in idiopathic steatorrhoea","volume":"36","author":"Stewart, J.S.; Pollock, D.J.; Hoffbrand, A.V.; Mollin, D.L.; Booth, C.C.","year":"1967","unstructured":"Stewart, J. S., Pollock, D. J., Hoffbrand, A. V., Mollin, D. L., and Booth, C. C. (1967). A study of proximal and distal intestinal structure and absorptive function in idiopathic steatorrhoea. Quart. J. Med., n.s., 36, 425-444.","journal-title":"Quart. J. Med., n.s"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1056\/NEJM197012032832302","article-title":"Epithelial-cell renewal in cultured duodenal biopsies in celiac sprue","volume":"283","author":"Trier, J.S.; Browning, T.H.","year":"1970","unstructured":"Trier, J. S., and Browning, T. H. (1970). Epithelial-cell renewal in cultured duodenal biopsies in celiac sprue. New Engl. J. Med., 283, 1245-1250.","journal-title":"New Engl. J. Med"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/gut.11.1.7","article-title":"Response of the jejunal mucosa in adult coeliac disease to oral prednisolone","volume":"11","author":"Wall, A.J.; Douglas, A.P.; Booth, C.C.; Pearse, A.G.E.","year":"1970","unstructured":"Wall, A. J., Douglas, A. P., Booth, C. C., and Pearse, A. G. E. (1970). Response of the jejunal mucosa in adult coeliac disease to oral prednisolone. Gut, 11, 7-14.","journal-title":"Gut"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/003591577206500619","article-title":"Automated histoquantitation studies of bone","volume":"65","author":"Williams, E.D.","year":"1972","unstructured":"Williams, E. D. (1972). Automated histoquantitation studies of bone. Proc. roy. Soc. Med., 65, 539-541.","journal-title":"Proc. roy. Soc. Med"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1056\/NEJM196212062672303","article-title":"Celiac disease: a study of the jejunal epithelium before and after a gluten-free diet","volume":"267","author":"Yardley, J.H.; Bayless, T.M.; Norton, J.H.; Hendrix, T.R.","year":"1962","unstructured":"Yardley, J. H., Bayless, T. M., Norton, J. H., and Hendrix, T. R. (1962). Celiac disease: a study of the jejunal epithelium before and after a gluten-free diet. New Engl. J. Med., 267, 1173-1179.","journal-title":"New Engl. J. Med"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.15.11.870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T19:27:07Z","timestamp":1757273227000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.15.11.870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,11]]},"references-count":24,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1974,11,1]]},"published-print":{"date-parts":[[1974,11]]}},"alternative-id":["10.1136\/gut.15.11.870"],"URL":"https:\/\/doi.org\/10.1136\/gut.15.11.870","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1974,11]]}}}