{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:42:20Z","timestamp":1770432140477,"version":"3.49.0"},"reference-count":27,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1974,12]]},"abstract":"<jats:p>The vitamin E status and ease of repletion in groups of children with coeliac disease, intestinal lymphangiectasia, and abetalipoproteinaemia was studied and compared with earlier studies in cystic fibrosis and obstructive jaundice. Each group represents an experimental model in which one of the transport steps involved in the absorption of vitamin E is defective or absent and thus the relative importance of these factors could be determined. Chylomicron formation and an adequate intraluminal concentration of bile salts were found to be the most important factors for the efficient absorption of the vitamin. The results in the five groups of patients have therapeutic implications if it is considered desirable to correct vitamin E deficiency states.<\/jats:p>","DOI":"10.1136\/gut.15.12.966","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"966-971","source":"Crossref","is-referenced-by-count":78,"title":["The relative importance of the factors involved in the absorption of vitamin E in children"],"prefix":"10.1136","volume":"15","author":[{"given":"D. P. R.","family":"Muller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. T.","family":"Harries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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PhD Thesis, University of London."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/archpedi.1956.02060030158010","article-title":"Studies of tocopherol deficiency in infants and children","volume":"92","author":"Nitowsky, H.M.; Cornblath, M.; Gordon, H.H.","year":"1956","unstructured":"Nitowsky, H. M., Cornblath, M., and Gordon, H. H. (1956). Studies of tocopherol deficiency in infants and children. Amer. J. Dis. Child., 92, 164-174.","journal-title":"Amer. J. Dis. Child"},{"issue":"399","key":"ref_22","first-page":"1","article-title":"Plasma vitamin A and E in the study of lipid and lipoprotein metabolism in coronary heart disease","volume":"174","author":"Pelkonen, R.","year":"1963","unstructured":"Pelkonen, R. (1963). Plasma vitamin A and E in the study of lipid and lipoprotein metabolism in coronary heart disease. 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