{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:50:50Z","timestamp":1787637050411,"version":"build-2736575974"},"reference-count":21,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1974,12]]},"abstract":"<jats:p>Using a pH-sensitive radiotelemetering device the effect of lactulose on luminal pH in the ileum, colon, and rectum has been compared with that of two other laxative agents.<\/jats:p>\n                  <jats:p>Lactulose produced marked acidification of proximal colonic contents but this effect was not consistently maintained into the distal colon. Sodium sulphate acidified distal rather than proximal colonic contents. However, for a similar degree of laxation it was not possible to produce a significantly more uniform reduction of pH along the length of the colon by combining these laxatives compared with lactulose alone. Magnesium sulphate had little effect upon luminal pH except in the rectum where a significant rise occurred.<\/jats:p>\n                  <jats:p>These results are discussed in relation to both normal colonic physiology and to their possible relevance to the treatment of chronic hepatic encephalopathy by colonic acidification.<\/jats:p>","DOI":"10.1136\/gut.15.12.999","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"999-1004","source":"Crossref","is-referenced-by-count":202,"title":["Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device"],"prefix":"10.1136","volume":"15","author":[{"given":"R. L.","family":"Bown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. E.","family":"Sladen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1974,12,1]]},"reference":[{"key":"ref_1","first-page":"859","article-title":"Faecal ammonia and pH during lactulose administration in man: comparison with other cathartics","volume":"13","author":"Agostini, L.; Down, P.F.; Murison, J.; Wrong, O.M.","year":"1972","unstructured":"Agostini, L., Down, P. F., Murison, J., and Wrong, O. M. (1972). Faecal ammonia and pH during lactulose administration in man: comparison with other cathartics. Gut, 13, 859-866."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3733\/hilg.v01n08p167","article-title":"The influence of feeding lactulose or dry skim milk on artificial infection of chicks with Eimeri avium","volume":"1","author":"Beach, J.R.; Davis, D.E.","year":"1925","unstructured":"Beach, J. R., and Davis, D. E. (1925). The influence of feeding lactulose or dry skim milk on artificial infection of chicks with Eimeri avium. Hilgardia, 1, 167-181.","journal-title":"Hilgardia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0002-9343(71)90233-6","article-title":"Treatment of chronic portal-systemic encephalopathy with lactulose","volume":"51","author":"Bircher, J.; Haemmerli, U.P.; Scollo-Lavizzari, G.; Hoffmann, K.","year":"1971","unstructured":"Bircher, J., Haemmerli, U. P., Scollo-Lavizzari, G., and Hoffmann, K. (1971). Treatment of chronic portal-systemic encephalopathy with lactulose. Amer. J. Med., 51, 148-159.","journal-title":"Amer. J. Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1042\/cs0430891","article-title":"A study of water and electrolyte transport by the excluded human colon","volume":"43","author":"Bown, R.L.; Sladen, G.E.; Rousseau, B.; Gibson, J.A.; Clark, M.L.; Dawson, A.M.","year":"1972","unstructured":"Bown, R. L., Sladen, G. E., Rousseau, B., Gibson, J. A., Clark, M. L., and Dawson, A. M. (1972). A study of water and electrolyte transport by the excluded human colon. Clin. Sci., 43, 891-902.","journal-title":"Clin. Sci"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/archsurg.1971.01350010027006","article-title":"Lactulose treatment of hepatic encephalopathy in outpatients","volume":"102","author":"Brown, H.; Trey, C.; McDermott, Jr, W.V.","year":"1971","unstructured":"Brown, H., Trey, C., McDermott, W. V., Jr. (1971). Lactulose treatment of hepatic encephalopathy in outpatients. Arch. Surg., 102, 25-27.","journal-title":"Arch. Surg"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/infdis\/32.3.175","article-title":"Factors controlling intestinal bacteria: the influence of hydrogen-ion concentration on bacterial types","volume":"32","author":"Cannon, P.R.; McNease, B.W.","year":"1923","unstructured":"Cannon, P. R., and McNease, B. W. (1923). Factors controlling intestinal bacteria: the influence of hydrogen-ion concentration on bacterial types. J. infect. Dis., 32, 175-180.","journal-title":"J. infect. 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Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/BF02239140","article-title":"Electrolyte absorption and secretion in the human colon","volume":"17","author":"Giller, J.; Phillips, S.F.","year":"1972","unstructured":"Giller, J., and Phillips, S. F. (1972). Electrolyte absorption and secretion in the human colon. Amer. J. dig. Dis., 17, 1003-1011.","journal-title":"Amer. J. dig. Dis"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0002-9343(65)90156-7","article-title":"Acquired milk intolerance in the adult caused by lactose malabsorption due to a selective deficiency of intestinal lactase activity","volume":"38","author":"G., Auricchio; S.; Prader, A.","year":"1965","unstructured":"G., Auricchio, S., and Prader, A. (1965). Acquired milk intolerance in the adult caused by lactose malabsorption due to a selective deficiency of intestinal lactase activity. Amer. J. Med., 38, 7-30.","journal-title":"Amer. J. Med"},{"key":"ref_14","first-page":"265","article-title":"Assessment and significance of bacterial overgrowth in the small bowel","volume":"39","author":"Hamilton, J.D.; Dyer, N.H.; Dawson, A.M.; O'Grady, F.W.; Vince, A.; Fenton, J.C.B.; Mollin, D.L.","year":"1970","unstructured":"Hamilton, J. D., Dyer, N. H., Dawson, A. M., O'Grady, F. W., Vince, A., Fenton, J. C. B., and Mollin, D. L. (1970). Assessment and significance of bacterial overgrowth in the small bowel. Quart. J. Med., 39, 265-285.","journal-title":"Quart. J. Med"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3181\/00379727-127-32882","article-title":"Absorption of lactic acid from an isolated intestinal segment in the intact rat","volume":"127","author":"Heller, M.D.; Kern, Jr, F.","year":"1968","unstructured":"Heller, M. D., and Kern, F., Jr. (1968). Absorption of lactic acid from an isolated intestinal segment in the intact rat. Proc. Soc. exp. Biol. (N.Y.), 127, 1103-1106. 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Lancet, 1, 717-720.","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1136\/bmj.2.5805.104","article-title":"pH profile of gut as measured by radiotelemetry capsule","volume":"2","author":"Meldrum, S.J.; Watson, B.W.; Riddle, H.C.; Bown, R.L.; Sladen, G.E.","year":"1972","unstructured":"Meldrum, S. J., Watson, B. W., Riddle, H. C., Bown, R. L., and Sladen, G. E. (1972). pH profile of gut as measured by radiotelemetry capsule. Brit. Med. J., 2, 104-106.","journal-title":"Brit. Med. J"},{"key":"ref_19","first-page":"355","article-title":"Drug-induced malabsorption of vitamin B1. IV. Malabsorption and deficiency of B12 during treatment with slow-release potassium chloride","volume":"191","author":"Palva, I.P.; Salokannel, S.J.; Timonen, T.; Palva, H.L.A.","year":"1972","unstructured":"Palva, I. P., Salokannel, S. J., Timonen, T., and Palva, H. L. A. (1972). Drug-induced malabsorption of vitamin B1. IV. 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