{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:54:25Z","timestamp":1758124465858,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1974,2]]},"abstract":"<jats:p>The effect of circulatory transit of the gastric fundus on serum levels of endogenous gastrin measured directly by radioimmunoassay has been studied in 14 dogs. Gastrin was measured in samples obtained simultaneously from the arterial inflow and venous outflow of the gastric fundus. During basal conditions, transit of the gastric fundus resulted in no change in gastrin concentration. During periods of stimulated gastrin release from the antrum, nine of the 14 dogs demonstrated a significant gastric acid secretory response. In these dogs there was a significant arteriovenous difference (approximately 30%) in circulating gastrin values. In the remaining five dogs, which did not demonstrate a significant gastric acid secretory response, there was no arteriovenous difference in circulating gastrin values. It is concluded that the gastric fundus is an important site for the inactivation of stimulated levels of circulating gastrin.<\/jats:p>","DOI":"10.1136\/gut.15.2.112","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"112-115","source":"Crossref","is-referenced-by-count":13,"title":["Extraction of circulating endogenous gastrin by the gastric fundus"],"prefix":"10.1136","volume":"15","author":[{"given":"John C. W.","family":"Evans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Reeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst D.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0016-5085(19)32982-8","article-title":"Extraction of circulating endogenous gastrin by the small bowel","volume":"65","author":"Becker, H.D.; Reeder, D.D.; Thompson, J.C.","year":"1973","unstructured":"Becker, H. D., Reeder, D. D., and Thompson, J. C. (1973). Extraction of circulating endogenous gastrin by the small bowel. 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Effect of nephrectomy on the rate and pattern of disappearance of exogenous gastrin in dogs. Gut, 14, 462-467.","journal-title":"Gut"},{"key":"ref_4","first-page":"129","article-title":"Effect of anesthesia on gastric secretion and circulating gastrin","volume":"15","author":"Evans, J.C.W.; Reeder, D.D.; Thompson, J.C.","year":"1972","unstructured":"Evans, J. C. W., Reeder, D. D., and Thompson, J. C. (1972). Effect of anesthesia on gastric secretion and circulating gastrin. Physiologist, 15, 129.","journal-title":"Physiologist"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0002-9610(72)90323-6","article-title":"Dynamic characteristics of gastrin release","volume":"123","author":"Jackson, B.M.; Reeder, D.D.; Thonpson, J.C.","year":"1972","unstructured":"Jackson, B. M., Reeder, D. D., and Thonpson, J. C. (1972). Dynamic characteristics of gastrin release. Amer. J. Surg., 123, 137-142.","journal-title":"Amer. J. Surg"},{"key":"ref_6","first-page":"531","article-title":"The effect of phenobarbital on the gastric secretions in dog and man","volume":"10","author":"Merendino, K.A.","year":"1948","unstructured":"Merendino, K. A. (1948). The effect of phenobarbital on the gastric secretions in dog and man. Gastroenterology, 10, 531-539.","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1152\/ajplegacy.1967.212.5.1001","article-title":"Sodium pentobarbital depression of histamineor insulin-stimulated gastric secretion","volume":"212","author":"Powell, D.W.; Hirschowitz, B.I.","year":"1967","unstructured":"Powell, D. W., and Hirschowitz, B. I. (1967). Sodium pentobarbital depression of histamineor insulin-stimulated gastric secretion. Amer. J. Physiol., 212, 1001-1006.","journal-title":"Amer. J. Physiol"},{"key":"ref_8","first-page":"34","article-title":"Preand posthepatic measurements of mass of endogenous gastrin","volume":"72","author":"Reeder, D.D.; Brandt, Jr., E.N.; Watson, L.C.; Hjelmquist, U.B.E.; Thompson, J.C.","year":"1972","unstructured":"Reeder, D. D., Brandt, E. N., Jr., Watson, L. C., Hjelmquist, U. B. E., and Thompson, J. C. (1972). Preand posthepatic measurements of mass of endogenous gastrin. Surgery, 72, 34-41.","journal-title":"Surgery"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1152\/ajplegacy.1972.222.6.1571","article-title":"Rate and pattern of disappearance of exogenous gastrin in dogs","volume":"222","author":"Reeder, D.D.; Jackson, B.M.; Brandt, Jr., E.N.; C, Thompson J.","year":"1972","unstructured":"Reeder, D. D., Jackson, B. M., Brandt, E. N., Jr., and Thompson. J. C. (1972). Rate and pattern of disappearance of exogenous gastrin in dogs. Amer. J. Physiol., 222, 1571-1574.","journal-title":"Amer. J. Physiol"},{"key":"ref_10","first-page":"574","article-title":"Effect of sodium pentobarbital on histamine stimulated gastric secretion, Amer","author":"Skyring, A.P.; Milton, G.W.; Maxwell, G.A.","year":"1961","unstructured":"Skyring, A. P., Milton, G. W., and Maxwell, G. A. (1961). Effect of sodium pentobarbital on histamine stimulated gastric secretion, Amer. J. Physiol., 201, 574-576.","journal-title":"J. Physiol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.me.20.020169.001451","article-title":"Gastrin and gastric secretion","volume":"20","author":"Thompson, J.C.","year":"1969","unstructured":"Thompson, J. C. (1969). Gastrin and gastric secretion. Ann. Rev. Med., 20, 291-314.","journal-title":"Ann. Rev. Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00000658-197209000-00014","article-title":"Effect of secretin on circulating gastrin","volume":"176","author":"Thompson, J.C.; Reeder, D.D.; Bunchman, H.H.; Becker, H.D.; Brandt, Jr, E.N.","year":"1972","unstructured":"Thompson, J. C., Reeder, D. D., Bunchman, H. H., Becker, H. D., and Brandt, E. N., Jr. (1972). Effect of secretin on circulating gastrin. Ann. Surg., 176, 384-393.","journal-title":"Ann. Surg"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0016-5085(70)80086-5","article-title":"Radioimmunoassay of gastrin","volume":"58","author":"Yalow, R.S.; Berson, S.A.","year":"1970","unstructured":"Yalow, R. S., and Berson, S. A. (1970). Radioimmunoassay of gastrin. 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