{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:59:39Z","timestamp":1763747979363,"version":"3.45.0"},"reference-count":16,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1974,4]]},"abstract":"<jats:p>Sera from 92 patients with adult coeliac disease, 20 patients with Crohn's disease, and 89 control patients were tested for the presence and immunoglobulin class of anticonnective tissue antibodies. In adult coeliac disease patients taking a normal diet there was a high frequency of sera positive for connective tissue antibodies and the majority were IgA in class. Following gluten withdrawal, IgA class connective tissue antibody activity was strikingly reduced. No such antibody activity was detected in concentrated jejunal fluid collected from 15 patients with adult coeliac disease, seven of whose sera were positive for connective tissue antibody.<\/jats:p>\n                  <jats:p>Connective tissue antibody activity was not absorbed by fractions of gluten. Similarly, preparations of human reticulin and glomerular basement membrane together with elastin and collagen failed to absorb connective tissue antibody.<\/jats:p>","DOI":"10.1136\/gut.15.4.284","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"284-288","source":"Crossref","is-referenced-by-count":22,"title":["Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease"],"prefix":"10.1136","volume":"15","author":[{"given":"A. F. N.","family":"Magalhaes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Doe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,4,1]]},"reference":[{"key":"ref_1","first-page":"682","article-title":"Autoantibodies to reticulin in patients with idiopathic steatorrhoea, coeliac disease, and Crohn's disease, and their relation to immunoglobulins and dietary antibodies","volume":"2","author":"Alp, M.H.; Wright, R.","year":"1971","unstructured":"Alp, M. H., and Wright, R. (1971). Autoantibodies to reticulin in patients with idiopathic steatorrhoea, coeliac disease, and Crohn's disease, and their relation to immunoglobulins and dietary antibodies. Lancet, 2, 682-685.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0140-6736(71)91779-X","article-title":"Unique antibody to basement membrane in patients with selective IgA deficiency and coeliac disease","volume":"1","author":"Ammann, A.J.; Hong, R.","year":"1971","unstructured":"Ammann, A. J., and Hong, R. (1971). Unique antibody to basement membrane in patients with selective IgA deficiency and coeliac disease. Lancet, 1, 1264-1266.","journal-title":"Lancet"},{"key":"ref_3","first-page":"373","article-title":"Autoantibodies in children with coeliac disease","volume":"13","author":"Brown, I.L.; Ferguson, A.; Carswell, F.; Horne, C.H.W.; MacSween, R.N.M.","year":"1973","unstructured":"Brown, I. L., Ferguson, A., Carswell, F., Horne, C. H. W., and MacSween, R. N. M. (1973). Autoantibodies in children with coeliac disease. Clin. exp. Immunol., 13, 373-382.","journal-title":"Clin. exp. Immunol"},{"key":"ref_4","first-page":"324","article-title":"An immunological study of adult coeliac disease","volume":"13","author":"Doe, W.F.; Henry, K.; Holt, L.; Booth, C.C.","year":"1972","unstructured":"Doe, W. F., Henry, K., Holt, L., and Booth, C. C. (1972). An immunological study of adult coeliac disease. Gut, 13, 324-325.","journal-title":"Gut"},{"key":"ref_5","first-page":"237","article-title":"Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implications","volume":"1","author":"Doniach, D.; Roitt, I.M.; Walker, J.G.; Sherlock, S.","year":"1966","unstructured":"Doniach, D., Roitt, I. M., Walker, J. G., and Sherlock, S. (1966). Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implications. Clin. exp. Immunol., 1, 237-262.","journal-title":"Clin. exp. Immunol"},{"key":"ref_6","first-page":"7","article-title":"The soluble fractions ofcollagen. In Practical Analytical Methods for Connective Tissue Proteins","author":"Eastoe, J.E.; Courts, A.","year":"1963","unstructured":"Eastoe, J. E., and Courts, A. (1963a). The soluble fractions ofcollagen. In Practical Analytical Methods for Connective Tissue Proteins, pp. 7-8. Spon, London."},{"key":"ref_7","first-page":"15","article-title":"Substances associated with the connective tissues. (a) Reticulin. In Practical Analytical Methods for Connective Tissue Proteins","author":"Eastoe, J.E.; Courts, A.","year":"1963","unstructured":"Eastoe, J. E., and Courts, A. (1963b). Substances associated with the connective tissues. (a) Reticulin. In Practical Analytical Methods for Connective Tissue Proteins, pp. 15-17. Spon, London."},{"key":"ref_8","first-page":"1157","article-title":"Reticulin antibody in children with malabsorption","volume":"1","author":"von Essen, R.; Savilahti, E.; Pelkonen, P.","year":"1972","unstructured":"von Essen, R., Savilahti, E., and Pelkonen, P. (1972). Reticulin antibody in children with malabsorption. Lancet, 1, 1157-1159.","journal-title":"Lancet"},{"key":"ref_9","first-page":"252","article-title":"Gluten-induced enteropathy: the effect of partially digested gluten","volume":"2","author":"Frazer, A.C.; Fletcher, R.F.; Ross, C.A.C.; Shaw, B.; Sammons, H.G.; Schneider, R.","year":"1959","unstructured":"Frazer, A. C., Fletcher, R. F., Ross, C. A. C., Shaw, B., Sammons, H. G., and Schneider, R. (1959). Gluten-induced enteropathy: the effect of partially digested gluten. 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Path"},{"key":"ref_12","first-page":"834","article-title":"Tissue antibodies in dermatitis herpetiformis and adult coeliac disease","volume":"1","author":"Seah, P.P.; Fry, L.; Hoffbrand, A.V.; Holborow, E.J.","year":"1971","unstructured":"Seah, P. P., Fry, L., Hoffbrand, A. V., and Holborow, E. J. (1971a). Tissue antibodies in dermatitis herpetiformis and adult coeliac disease. Lancet, 1, 834-836.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/gut.14.4.311","article-title":"Anti-reticulin antibody: incidence and diagnostic significance","volume":"14","author":"Seah, P.P.Fry; L., Holborow; J., E.; Rossiter, M.A.; Doe, W.F.; Magalhaes, A.F.; Hoffbrand, A.V.","year":"1973","unstructured":"Seah, P. P. Fry, L., Holborow, E. J., Rossiter, M. A., Doe, W. F., Magalhaes, A. F., and Hoffbrand, A. V. (1973). Anti-reticulin antibody: incidence and diagnostic significance. Gut, 14, 311-315.","journal-title":"Gut"},{"key":"ref_14","first-page":"681","article-title":"Anti-reticulin antibodies in childhood coeliac disease","volume":"2","author":"Seah, P.P.; Fry, L.; Rossiter, M.A.; Hoffbrand, A.V.; Holborow, E.J.","year":"1971","unstructured":"Seah, P. P., Fry, L., Rossiter, M. A., Hoffbrand, A. V., and Holborow, E. J. (1971b). Anti-reticulin antibodies in childhood coeliac disease. Lancet, 2, 681-682.","journal-title":"Lancet"},{"key":"ref_15","first-page":"611","article-title":"Immunoglobulins in the skin in dermatitis herpetiformis and coeliac disease","volume":"1","author":"Seah, P.P.; Fry, L.; Stewart, J.S.; Chapman, B.L.; Hoffbrand, A.V.; Holborow, E.J.","year":"1972","unstructured":"Seah, P. P., Fry, L., Stewart, J. S., Chapman, B. L., Hoffbrand, A. V., and Holborow, E. J. (1972). Immunoglobulins in the skin in dermatitis herpetiformis and coeliac disease. 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