{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:03:12Z","timestamp":1770822192898,"version":"3.50.1"},"reference-count":12,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1974,5]]},"abstract":"<jats:p>The cell population of the upper jejunal mucosa has been studied in cases of tropical sprue from the Far East and Middle East, and in similar cases arising in western Europe (`post-infective malabsorption'), and compared with cases of untreated coeliac disease and patients without small bowel disease.<\/jats:p>\n                  <jats:p>Infiltration of the epithelial layer of the upper jejunal mucosa by lymphocytes was found in tropical sprue to the same extent as in coeliac disease, and, to a lesser extent, in `postinfective malabsorption'.<\/jats:p>\n                  <jats:p>In the lamina propria, in all forms of acute sprue there was an increased density of lymphocytes. With increasing duration and with increasing mucosal atrophy, the lymphocytes were progressively replaced by plasma cells, and the cellular infiltration in chronic sprue was indistinguishable from that of coeliac disease.<\/jats:p>\n                  <jats:p>The findings suggest that a humoral antibody response is a feature of sprue, and becomes more prominent as the condition becomes chronic.<\/jats:p>","DOI":"10.1136\/gut.15.5.387","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"387-391","source":"Crossref","is-referenced-by-count":38,"title":["The cell population of the upper jejunal mucosa in tropical sprue and postinfective malabsorption"],"prefix":"10.1136","volume":"15","author":[{"given":"R. D.","family":"Montgomery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C. I.","family":"Shearer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,5,1]]},"reference":[{"key":"ref_1","year":"1961","unstructured":"Chacko, C. J. G., Job, C. K., Johnson, S., and Baker,-S. J. (1961)."},{"key":"ref_2","series-title":"Coeliac Disease: Proceedings of an International Conference","first-page":"134","article-title":"Immunopathology and coeliac disease","author":"Crabbe, P.A.; Douglas, A.P.; Hobbs, J.R.","year":"1970","unstructured":"Crabbe, P. A., Douglas, A. P., and Hobbs, J. R. (1970). Immunopathology and coeliac disease. In Coeliac Disease: Proceedings of an International Conference, edited by C. C. Booth and R. H. 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Appearances of the jejunal mucosa in acute tropical sprue in Singapore. Gut, 7, 128-139.","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1136\/gut.12.12.988","article-title":"Quantitation of epithelial lymphocytes in human jejunum","volume":"12","author":"Ferguson, A.; Murray, D.","year":"1971","unstructured":"Ferguson, A., and Murray, D. (1971). Quantitation of epithelial lymphocytes in human jejunum. Gut, 12, 988-994.","journal-title":"Gut"},{"key":"ref_6","author":"Haeney, M.R.; Montgomery, R.D.; Schneider, R.","year":"1974","unstructured":"Haeney, M. R., Montgomery, R. D., and Schneider, R. (1974)."},{"key":"ref_7","article-title":"Sprue in the Middle East: Five case reports","volume":"15","author":"Holmes, G.K.T.; Asquith, P.; Stokes, P.L.; Cooke, W.T.","year":"1973","unstructured":"Sprue in the Middle East: Five case reports. Gut, 15, Holmes, G. K. T., Asquith, P., Stokes, P. L., and Cooke, W. T. (1973).","journal-title":"Gut"},{"key":"ref_8","article-title":"Postinfective malabsorption: a sprue syndrome","volume-title":"Brit.","author":"Montgomery, R.D.Beale; J., D.; Sammons, H.G.; Schneider, R.","year":"1973","unstructured":"Montgomery, R. D. Beale, D. J., Sammons, H. G., and Schneider, R. (1973). Postinfective malabsorption: a sprue syndrome. Brit."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0016-5085(19)34471-3","article-title":"Peroral biopsy of the small intestine: a review of its diagnostic usefulness","volume":"49","author":"Rubin, C. E.; Dobbins, W. 0. III","year":"1965","unstructured":"Rubin, C. E., and Dobbins, W. 0. III, (1965). Peroral biopsy of the small intestine: a review of its diagnostic usefulness. Gastroenterology, 49, 676-697.","journal-title":"Gastroenterology"},{"key":"ref_10","article-title":"Personal communication","author":"Thompson, H.","year":"1973","unstructured":"Thompson, H. (1973). Personal communication."},{"key":"ref_11","author":"Thurlbeck, W.M.; Benson, Jr., J.A.; Dudley, Jr, H.R.","year":"1960","unstructured":"Thurlbeck, W. M., Benson, J. A., Jr., and Dudley, H. R., Jr. (1960)."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/jcp.s3-5.1.108","article-title":"The interpretation and significance of morphological abnormalities in jejunal biopsies","volume":"24","author":"Whitehead, R.","year":"1971","unstructured":"Whitehead, R. (1971). The interpretation and significance of morphological abnormalities in jejunal biopsies. J. clin. Path., 24, suppl. (Roy. Coll. Path.) 5, 108-124.","journal-title":"J. clin. 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