{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T19:09:01Z","timestamp":1763752141850,"version":"3.45.0"},"reference-count":17,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1974,5]]},"abstract":"<jats:p>Two patients with primary gastric carcinoma and multiple liver secondaries who developed alpha fetoprotein in the serum are reported. Both had clinical features which were initially suggestive of primary liver cell carcinoma. Fetoprotein levels fell after ligation of the hepatic artery in one patient. Alpha fetoprotein may occur in the serum of adult patients with tumours of the foregut, other than primary liver cell carcinoma, when such tumours have metastasized to the liver.<\/jats:p>","DOI":"10.1136\/gut.15.5.401","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"401-403","source":"Crossref","is-referenced-by-count":5,"title":["Alpha fetoprotein in metastatic gastric carcinoma"],"prefix":"10.1136","volume":"15","author":[{"given":"J.","family":"Kelleher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sister","family":"Colum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hennessy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Whelton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,5,1]]},"reference":[{"key":"ref_1","first-page":"551558","article-title":"Embryonal serum a globulin in cancer patients: diagnostic value","volume":"2","author":"Abelev, G.I.; Assecritova, I.V.; Kraevsky, N.A.; D., Perova S.; Perevodchikova, N.I.","year":"1967","unstructured":"Abelev, G. I., Assecritova, I. V., Kraevsky, N. A., Perova. S. D., and Perevodchikova, N. I. (1967). Embryonal serum a globulin in cancer patients: diagnostic value. Int. J. Cancer, 2, 551558.","journal-title":"Int. J. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM197111042851905","article-title":"Alpha-feto. protein in a patient with gastric carcinoma metastatic to the liver","volume":"285","author":"Alpert, E.; Pinn, V.W.; Isselbacher, K.J.","year":"1971","unstructured":"Alpert, E., Pinn, V. W., and Isselbacher, K. J. (1971). Alpha-feto. protein in a patient with gastric carcinoma metastatic to the liver. New Engl. J. Med., 285, 1058-1059.","journal-title":"New Engl. J. Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1056\/NEJM196805022781804","article-title":"Alpha, feto. globulin in the diagnosis of human hepatoma","volume":"278","author":"Alpert, M.E.; Uriel, J.; de Nechaud, B.","year":"1968","unstructured":"Alpert, M. E., Uriel, J., and de Nechaud, B. (1968). Alpha, feto. globulin in the diagnosis of human hepatoma. New Engl. J. Med., 278, 984.986.","journal-title":"New Engl. J. Med"},{"key":"ref_4","first-page":"12771278","article-title":"Existence d'alpha foeto proteine au cours d'un cancer secondaire du foie d'origine gastrique","volume":"78","author":"Bourreille, J.; Metayer, P.; Sauger, F.; Matray, F.; Fondimare, A.","year":"1970","unstructured":"Bourreille, J., Metayer, P., Sauger, F., Matray, F., and Fondimare, A. (1970). Existence d'alpha foeto proteine au cours d'un cancer secondaire du foie d'origine gastrique. Presse mid., 78, 12771278.","journal-title":"Presse mid"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/bmj.3.5822.351-c","article-title":"Alpha-fetoprotein and gastric carcinoma","volume":"3","author":"Castleden, C.M.; Davies, J.D.","year":"1972","unstructured":"Castleden, C. M., and Davies, J. D. (1972). Alpha-fetoprotein and gastric carcinoma. (Letter) Brit. med. J., 3, 351-352.","journal-title":"(Letter) Brit. med. J"},{"key":"ref_6","first-page":"516","article-title":"Abdominal arterial murmurs in liver disease","volume":"2","author":"Clain, D.; Wartnaby, K.; Sherlock, S.","year":"1966","unstructured":"Clain, D., Wartnaby, K., and Sherlock, S. (1966). Abdominal arterial murmurs in liver disease. 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(Letter) Presse mid., 78, 1896.","journal-title":"(Letter) Presse mid"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev.me.22.020171.000505","article-title":"Antigenic reversion in human cancer","volume":"22","author":"Gold, P.","year":"1971","unstructured":"Gold, P. (1971). Antigenic reversion in human cancer. Ann. Rev. Med., 22, 85-94.","journal-title":"Ann. Rev. Med"},{"key":"ref_10","article-title":"Hypoglycaemic coma as a presenting feature of hepatic malignancy","author":"Kelleher, J.; O'Sullivan, D.J.; Doyle, D.; Whelton, M.J.","year":"1974","unstructured":"Kelleher, J., O'Sullivan, D. J., Doyle, D., and Whelton, M. J. (1974). Hypoglycaemic coma as a presenting feature of hepatic malignancy. (In preparation)."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1056\/NEJM197111042851906","article-title":"Positive alpha-fetoglobulin in a case of gastric carcinoma","volume":"285","author":"Kozower, M.; Fawaz, K.A.; Miller, H.M.; Kaplan, M.M.","year":"1971","unstructured":"Kozower, M., Fawaz, K. A., Miller, H. M., and Kaplan, M. M. (1971). Positive alpha-fetoglobulin in a case of gastric carcinoma. New Engl. J. Med., 285, 1059-1060.","journal-title":"New Engl. J. Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1056\/NEJM197111042851907","article-title":"Serum alpha1-fetoglobulin with gastric and prostatic carcinomas","volume":"285","author":"Mehlman, D.J.; Bukley, B.H.; Wiernik, P.H.","year":"1971","unstructured":"Mehlman, D. J., Bukley, B. H., and Wiernik, P. H. (1971). Serum alpha1-fetoglobulin with gastric and prostatic carcinomas. New Engl. J. Med., 285, 1060.1061.","journal-title":"New Engl. J. Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/1097-0142(197005)25:5<1091::AID-CNCR2820250514>3.0.CO;2-P","article-title":"A collaborative study for the evaluation of a serologic test for primary liver cancer","volume":"25","author":"O'Conor, G.T.; Tatarinov, Y.S.; Abelev, G.I.; Uriel, J.","year":"1970","unstructured":"O'Conor, G. T., Tatarinov, Y. S., Abelev, G. I., and Uriel, J. (1970). A collaborative study for the evaluation of a serologic test for primary liver cancer. Cancer (Philad.), 25, 1091-1098.","journal-title":"Cancer (Philad.)"},{"key":"ref_14","first-page":"375","article-title":"a-Fetoproteinin normal'and pregnancy sera","volume":"1","author":"Sepptla, M.; Ruoslahti, E.","year":"1972","unstructured":"Sepptla, M., and Ruoslahti, E. (1972). a-Fetoproteinin normal'and pregnancy sera. (Letter) Lancet, 1, 375-376.","journal-title":"(Letter) Lancet"},{"key":"ref_15","first-page":"344","article-title":"Content of embryo-specific a globulin in fetal and neonatal sera and sera from adult humans with primary carcinoma of the liver","volume":"25","author":"Tatarinov, Y.S.","year":"1966","unstructured":"Tatarinov, Y. S. (1966). Content of embryo-specific a globulin in fetal and neonatal sera and sera from adult humans with primary carcinoma of the liver. Fed. Proc. Transl. Suppl., 25, 344-346.","journal-title":"Fed. Proc. Transl. Suppl"},{"key":"ref_16","first-page":"11121115","article-title":"Serum-alpha-fetoprotein levels in patients with ataxia-telangiectasia","volume":"2","author":"Waldmann, T.A.; McIntire, K.R.","year":"1972","unstructured":"Waldmann, T. A., and McIntire, K. R. (1972). Serum-alpha-fetoprotein levels in patients with ataxia-telangiectasia. 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(1972)."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.15.5.401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T19:04:02Z","timestamp":1763751842000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.15.5.401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,5]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1974,5,1]]},"published-print":{"date-parts":[[1974,5]]}},"alternative-id":["10.1136\/gut.15.5.401"],"URL":"https:\/\/doi.org\/10.1136\/gut.15.5.401","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1974,5]]}}}