{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T09:16:55Z","timestamp":1765617415317,"version":"3.48.0"},"reference-count":26,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1974,5]]},"abstract":"<jats:p>\n                    <jats:sup>67<\/jats:sup>\n                    Gallium (\n                    <jats:sup>67<\/jats:sup>\n                    Ga) citrate liver scanning has been carried out on 60 selected patients following a scan with a radioactive colloid preparation.\n                  <\/jats:p>\n                  <jats:p>\n                    The\n                    <jats:sup>67<\/jats:sup>\n                    Ga scan correctly identified the site of primary liver carcinoma in 14 of 16 patients, including nine of 10 patients in whom the carcinoma arose in a cirrhotic liver, whereas a colloid scan positively identified the site in only four of these 10 cirrhotic subjects. Alpha-1-fetoprotein estimation was positive in eight of the 16 patients, including the two in whom\n                    <jats:sup>67<\/jats:sup>\n                    Ga scanning was negative. No positive\n                    <jats:sup>67<\/jats:sup>\n                    Ga scans were seen in 15 patients with cirrhosis but no primary liver cell cancer in whom a space-occupying lesion could not be excluded on colloid scan.\n                    <jats:sup>67<\/jats:sup>\n                    Ga citrate scanning appears to be the most reliable investigation available in the diagnosis of primary liver cell cancer. Uptake of\n                    <jats:sup>67<\/jats:sup>\n                    Ga in secondary metastatic tumours within the liver was less frequent, and appears to have much less value in the detection of these lesions and of bile duct carcinoma than in primary liver cell carcinoma.\n                  <\/jats:p>\n                  <jats:p>\n                    The\n                    <jats:sup>67<\/jats:sup>\n                    Ga scan was positive in six out of six patients with pyogenic abscess either in the liver or adjacent to it. In four of these patients a preceding colloid scan had shown no definite filling defect in the liver.\n                  <\/jats:p>","DOI":"10.1136\/gut.15.5.404","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"404-410","source":"Crossref","is-referenced-by-count":23,"title":["<sup>67<\/sup>\n                    Gallium scanning in the diagnosis of liver disease"],"prefix":"10.1136","volume":"15","author":[{"given":"Oliver","family":"James","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. J.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Sherlock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,5,1]]},"reference":[{"key":"ref_1","first-page":"709","article-title":"The distribution and concentration of 76Se-selenomethionine in man","volume":"10","author":"Ben-Porath, M.; Kaplan, E.","year":"1969","unstructured":"Ben-Porath, M., and Kaplan, E. (1969). The distribution and concentration of 76Se-selenomethionine in man. J. nucl. Med., 10, 709-710.","journal-title":"J. nucl. 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(1971). \"7Se-selenomethionine in the scintiscan diagnosis of primary hepatocellular carcinoma. Gut, 12, 245-249.","journal-title":"Gut"},{"key":"ref_4","first-page":"103","article-title":"Tumor scanning with '7Ga citrate","volume":"10","author":"Edwards, C.L.; Hayes, R.L.","year":"1969","unstructured":"Edwards, C. L., and Hayes, R. L. (1969). Tumor scanning with '7Ga citrate. J. nucl. Med., 10. 103-105.","journal-title":"J. nucl. Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1001\/jama.1970.03170200048007","article-title":"Scanning malignant neoplasms with gallium 67","volume":"212","author":"Edwards, C.L.; Hayes, R.L.","year":"1970","unstructured":"Edwards, C. L., and Hayes, R. L. (1970). Scanning malignant neoplasms with gallium 67. J. Amer. med. Ass., 212, 1182-1190.","journal-title":"J. Amer. med. Ass"},{"key":"ref_6","first-page":"371","article-title":"\"Ga scintigraphy of malignant tumours","volume":"11","author":"Fogh, J.; Edeling, C.J.","year":"1972","unstructured":"Fogh, J., and Edeling, C. J. (1972). \"Ga scintigraphy of malignant tumours. Nucl. Med. (Stuttg.), 11, 371-395.","journal-title":"Nucl. Med. (Stuttg.)"},{"key":"ref_7","first-page":"402","article-title":"Practical application of Ga'7 citrate to the evaluation of liver pathology","volume":"14","author":"Grove, R.B.; Madewell, J.E.; Rapp, G.S.; Pinsky, S.M.; Johnson, M.C.","year":"1973","unstructured":"Grove, R. B., Madewell, J. E., Rapp, G. S., Pinsky, S. M., and Johnson, M. C. (1973). Practical application of Ga'7 citrate to the evaluation of liver pathology. (Abst.). J. nucl. Med., 14, 402.","journal-title":"(Abst.). J. nucl. 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The use of \"Tcm antimony sulphide colloid for liver scanning: its preparation and some clinical and experimental observations. Brit. J. Radiol., 42, 657-661.","journal-title":"Brit. J. Radiol"},{"key":"ref_10","series-title":"unsuspected sites of neoplastic disease. In Medical-Radioisotope Scintigraphy 1972: Proceedings of a Symposium held... in Monte Carlo, Vol. II","first-page":"641","article-title":"Localisation of gallium-67 citrate","author":"Kramer, R.J.; Larson, S.M.; Milder, M.S.; Hedt, J.R.; Johnson, R.E.; De Vita, V.T.; Johnson, G.S.","year":"1973","unstructured":"Kramer, R. J., Larson, S. M., Milder, M. S., Hedt, J. R., Johnson, R. E., De Vita, V. T., and Johnson, G. S. (1973). Localisation of gallium-67 citrate in unsuspected sites of neoplastic disease. In Medical-Radioisotope Scintigraphy 1972: Proceedings of a Symposium held... in Monte Carlo, Vol. II, pp. 641-655. 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The value of"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1259\/0007-1285-44-521-361","article-title":"Gallium 67 citrate scanning in neoplastic and inflammatory lesions","volume":"44","author":"Lavender, J.P.; Lowe, J.; Barker, J.R.; Burn, J.I.; Chaudhri, M.A.","year":"1971","unstructured":"Lavender, J. P., Lowe, J., Barker, J. R., Burn, J. I., and Chaudhri, M. A. (1971). Gallium 67 citrate scanning in neoplastic and inflammatory lesions. Brit. J. Radiol., 44, 361-366.","journal-title":"Brit. J. Radiol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.7326\/0003-4819-79-3-403","article-title":"Gallium 67 for localisation of septic lesions","volume":"79","author":"Littenberg, R.L.; Taketa, R.M.; Alazraki, N.P.; Halpern, S.E.; Ashburn, W.L.","year":"1973","unstructured":"Littenberg, R. L., Taketa, R. M., Alazraki, N. P., Halpern, S. E., and Ashburn, W. L. (1973). Gallium 67 for localisation of septic lesions. Ann. Intern. 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Radiology, 105, 689-192.","journal-title":"Radiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1001\/archinte.1965.03870010097012","article-title":"Diagnostic value of scintillation scanning of the liver","volume":"116","author":"McAfee, J.G.; Ause, R.G.; Wagner, Jr, H.N.","year":"1965","unstructured":"McAfee, J. G., Ause, R. G., and Wagner, H. N., Jr. (1965). Diagnostic value of scintillation scanning of the liver. Arch. Intern. Med., 116, 95-110.","journal-title":"Arch. Intern. Med"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1001\/jama.1973.03220060062021","article-title":"Gallium 67 accumulation in pulmonary sarcoidosis","volume":"223","author":"McKusick, K.A.; Soin, J.S.; Ghiladi, A.; Wagner, Jr, H.N.","year":"1973","unstructured":"McKusick, K. A., Soin, J. S., Ghiladi, A., and Wagner, H. N., Jr. (1973). Gallium 67 accumulation in pulmonary sarcoidosis. (Letter). J. Amer. med. Ass., 223, 688.","journal-title":"(Letter). J. Amer. med. Ass"},{"issue":"594","key":"ref_19","series-title":"Medical Radioisotope Scintigraphy 1972: Proceedings of a Symposium held... in Monte Carlo, Vol. II","first-page":"pp.","article-title":"Tumour detection with gallium-67-citrate","volume":"583","author":"International Atomic Energy Agency,","year":"1973","unstructured":"Manfredi, 0. L., Quinones, J. D., and Bartok, S. P. (1973). Tumour detection with gallium-67-citrate. In Medical Radioisotope Scintigraphy 1972: Proceedings of a Symposium held... in Monte Carlo, Vol. II, pp. 583 594. International Atomic Energy Agency, Vienna."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"880","DOI":"10.2214\/ajr.97.4.880","article-title":"Simplified preparation of technetium 99m sulfide colloid for liver scanning","volume":"97","author":"Patton, D.D.; Garcia, E.N.; Webber, M.M.","year":"1966","unstructured":"Patton, D. D., Garcia, E. N., and Webber, M. M. (1966). Simplified preparation of technetium 99m sulfide colloid for liver scanning. Amer. J. Roentgenol, 97, 880-885.","journal-title":"Amer. J. Roentgenol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2214\/ajr.113.1.92","article-title":"Positive scintiphotography of cancer of the liver with Ga'7 citrate Amer","volume":"113","author":"Suzuki, T.; Honjo, I.; Hamamoto, K.; Kousaka, T.; Torizuka, K.","year":"1971","unstructured":"Suzuki, T., Honjo, I., Hamamoto, K., Kousaka, T., and Torizuka, K. (1971). Positive scintiphotography of cancer of the liver with Ga'7 citrate Amer. J. Roentgenol., 113, 92-103.","journal-title":"J. Roentgenol"},{"key":"ref_22","first-page":"539","article-title":"Erfahrungen fiber die Galliumszintigraphie in einer Tumoklinik","volume":"142","author":"Trapp, P.; Sieslack, R.; Goepfert, H.; Hellriegel, W.","year":"1971","unstructured":"Trapp, P., Sieslack, R., Goepfert, H., and Hellriegel, W. (1971). Erfahrungen fiber die Galliumszintigraphie in einer Tumoklinik. Strahlentherapie, 142, 539-545.","journal-title":"Strahlentherapie"},{"key":"ref_23","series-title":"Medical Radioisotope Scintigraphy 1972: Proceedings of a Symposium held... in Monte","article-title":"Gallium 67 scanning in the staging of Hodgkins disease","author":"Turner, D.A.; Gottschalk, A.; Hoffer, P.B.; Harper, P.V.; Moran, E.; Ultmann, J.E.","year":"1973","unstructured":"Turner, D. A., Gottschalk, A., Hoffer, P. B., Harper, P. V., Moran, E., and Ultmann, J. E. (1973). Gallium 67 scanning in the staging of Hodgkins disease. In Medical Radioisotope Scintigraphy 1972: Proceedings of a Symposium held... in Monte"},{"key":"ref_24","first-page":"615","volume":"II,","author":"Carlo, Vol","unstructured":"Carlo, Vol. II, pp. 615-630. 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Visualisation of tumors in humans using '7Ga-citrate. J. nucl. Med., 11, 459-466.","journal-title":"J. nucl. Med"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.15.5.404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T09:13:07Z","timestamp":1765617187000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.15.5.404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,5]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1974,5,1]]},"published-print":{"date-parts":[[1974,5]]}},"alternative-id":["10.1136\/gut.15.5.404"],"URL":"https:\/\/doi.org\/10.1136\/gut.15.5.404","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1974,5]]}}}