{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:05:29Z","timestamp":1765638329843,"version":"3.48.0"},"reference-count":19,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1974,6]]},"abstract":"<jats:p>Lymphocytes and plasma cells in the lamina propria and lymphocyte in the epithelium have been quantitated in jejunal biopsies from 18 patients with coeliac disease who developed lymphoma. In six patients two or more serial biopsies were available for study. Counts were compared with those obtained in 15 healthy controls and 30 other coeliacs, 15 of whom have been on a gluten-free diet for more than 12 months.<\/jats:p>\n                  <jats:p>Results showed that although the lymphoma patients have abnormal counts compared with controls, they differed from untreated coeliacs in that they had lower plasma cell and higher lymphocyte counts in the lamina propria and lower lymphocyte counts in the epithelium. Such changes tended to be present for up to five years before the diagnosis of lymphoma was made. The results suggest that the immunological status of coeliac patients with lymphoma differs from that of other coeliacs and it could represent a primary abnormality and also be relevant to the development of lymphoma.<\/jats:p>","DOI":"10.1136\/gut.15.6.458","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"458-461","source":"Crossref","is-referenced-by-count":34,"title":["The jejunal cellular infiltrate in coeliac disease complicated by lymphoma"],"prefix":"10.1136","volume":"15","author":[{"given":"R.","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Asquith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. T.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0140-6736(69)92440-4","article-title":"Serum immunoglobulins in adult coeliac disease","volume":"2","author":"Asquith, P.; Thompson, R.A.; Cooke, W.T.","year":"1969","unstructured":"Asquith, P., Thompson, R. A., and Cooke, W. T. (1969). Serum immunoglobulins in adult coeliac disease. Lancet, 2, 129-131.","journal-title":"Lancet"},{"key":"ref_2","first-page":"475","article-title":"Steatorrhoea and malignant lymphoma","volume":"12","author":"Austad, W.I.; Cornes, J.S.; Gough, K.R.; McCarthy, C.F.; Read, A.E.","year":"1967","unstructured":"Austad, W. I., Cornes, J. S., Gough, K. R., McCarthy, C. F., and Read, A. E. (1967). Steatorrhoea and malignant lymphoma. Amer. J. dig. Res., 12, 475-490.","journal-title":"Amer. J. dig. Res"},{"key":"ref_3","first-page":"665","article-title":"Coeliac disease and malignancy","volume":"42","author":"Barry, R.E.; Read, A.E.","year":"1973","unstructured":"Barry, R. E., and Read, A. E. (1973). Coeliac disease and malignancy. Quart. J. Med., 42, 665-675.","journal-title":"Quart. J. Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/gut.10.1.57","article-title":"Serum immunoglobulins and lymphocyte transformation studies in coeliac disease","volume":"10","author":"Blecher, T.E.; Brzechwa-Ajdukiewicz, A.; McCarthy, C.F.; Read, A.E.","year":"1969","unstructured":"Blecher, T. E., Brzechwa-Ajdukiewicz, A., McCarthy, C. F., and Read, A. E. (1969). Serum immunoglobulins and lymphocyte transformation studies in coeliac disease. Gut, 10, 57-62.","journal-title":"Gut"},{"key":"ref_5","first-page":"1","article-title":"The concept of immunological surveillance","volume":"13","author":"Burnet, F.M.","year":"1970","unstructured":"Burnet, F. M. (1970). The concept of immunological surveillance. Progr. exp. Twnour Res., 13, 1-27.","journal-title":"Progr. exp. Twnour Res"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0140-6736(64)90238-7","article-title":"Simple capsule for multiple intestinal biopsy specimens","volume":"2","author":"Choudhury, D.C.R.; Nicholson, G.I.; Cooke, W.T.","year":"1964","unstructured":"Choudhury, D. C. R., Nicholson, G. I., and Cooke, W. T. (1964). Simple capsule for multiple intestinal biopsy specimens. Lancet, 2, 185-186.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1136\/gut.12.12.988","article-title":"Quantitation of intraepithelial lymphocytes in human jejunum","volume":"12","author":"Ferguson, A.; Murray, D.","year":"1971","unstructured":"Ferguson, A., and Murray, D. (1971). Quantitation of intraepithelial lymphocytes in human jejunum. Gut, 12, 988-994.","journal-title":"Gut"},{"key":"ref_8","first-page":"477","article-title":"The effect of antigen deprivation on thymus dependent and thymus independent lymphocytes in the small intestine of the mouse","volume":"12","author":"Ferguson, A.; Parrott, D.M.V.","year":"1972","unstructured":"Ferguson, A., and Parrott, D. M. V. (1972). The effect of antigen deprivation on thymus dependent and thymus independent lymphocytes in the small intestine of the mouse. Clin. exp. Immunol., 12, 477-488.","journal-title":"Clin. exp. Immunol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/bmj.3.5823.371","article-title":"Lymphocytic infiltration of epithelium in diagnosis of gluten sensitive enteropathy","volume":"3","author":"Fry, L.; Seah, P.P.; McMin, R.M.H.; Hoffbrand, A.V.","year":"1972","unstructured":"Fry, L., Seah, P. P., McMin, R. M. H., and Hoffbrand, A. V. (1972). Lymphocytic infiltration of epithelium in diagnosis of gluten sensitive enteropathy. Brit. med. J., 3, 371-374.","journal-title":"Brit. med. J"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/gut.3.3.232","article-title":"Intestinal reticulosis as a complication of idiopathic steatorrhoea","volume":"3","author":"Gough, K.R.; Read, A.E.; Naish, J.M.","year":"1962","unstructured":"Gough, K. R., Read, A. E., and Naish, J. M. (1962). Intestinal reticulosis as a complication of idiopathic steatorrhoea. Gut, 3, 232-239.","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0002-9343(67)90071-X","article-title":"Malignancy in adult coeliac disease and idiopathic steatorrhoea","volume":"42","year":"1967","unstructured":"Harris, 0. D., Cooke, W. T., Thompson, H., and Waterhouse, J. A. H. (1967). Malignancy in adult coeliac disease and idiopathic steatorrhoea. Amer. J. Med., 42, 899-912.","journal-title":"Amer. J. Med"},{"issue":"429","key":"ref_12","article-title":"Cellular infiltrate of jejunal biopsies in adult coeliac disease (A. C. D.) in relation to gluten withdrawal","volume":"14","author":"Holmes, G.K.T.; Asquith, P.; Stokes, P.L.; Cooke, W.T.","year":"1973","unstructured":"Holmes, G. K. T., Asquith, P., Stokes, P. L., and Cooke, W. T. (1973.) Cellular infiltrate of jejunal biopsies in adult coeliac disease (A.C.D.) in relation to gluten withdrawal. (Abstr.) Gut, 14,429.","journal-title":"(Abstr.) Gut"},{"key":"ref_13","first-page":"980","article-title":"Responses to phytohaemaglutinin","volume":"1","author":"Holt, P.J.; Ling, N.R.; Winter, G.C.B.; McCarthy, C.F.; Read, A.E.; Yoffey, J.M.","year":"1966","unstructured":"Holt, P. J., Ling, N. R., Winter, G. C. B., McCarthy, C. F., Read, A. E., and Yoffey, J. M. (1966). Responses to phytohaemaglutinin. Lancet, 1, 980-981.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/bmj.2.5650.159","article-title":"Immune response to gluten in adult coeliac disease","volume":"2","author":"Housley, J.; Asquith, P.; Cooke, W.T.","year":"1969","unstructured":"Housley, J., Asquith, P., and Cooke, W. T. (1969). Immune response to gluten in adult coeliac disease. Brta. med. J., 2, 159-161.","journal-title":"Brta. med. J"},{"key":"ref_15","first-page":"409","article-title":"The lymphocyte","volume":"1","author":"Lancet","year":"1973","unstructured":"Lancet (1973). The lymphocyte. Editorial. Lancet, 1, 409-410.","journal-title":"Editorial. Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1136\/gut.12.10.794","article-title":"Impaired lymphocyte reactivity against tumour cells in patients with coeliac disease","volume":"12","author":"MacLaurin, B.P.; Cooke, W.T.; Ling, M.R.","year":"1971","unstructured":"MacLaurin, B. P., Cooke, W. T., and Ling, M. R. (1971). Impaired lymphocyte reactivity against tumour cells in patients with coeliac disease. Gut, 12, 794-800.","journal-title":"Gut"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000230494","article-title":"The significance of immunoglobulin determinants on the lymphocyte surface","volume":"41","author":"Roitt, 1. M","year":"1971","unstructured":"Roitt, 1. M. (1971). The significance of immunoglobulin determinants on the lymphocyte surface. Int. Arch. Allergy appl. Immunol., 41, 96-97.","journal-title":"Int. Arch. Allergy appl. Immunol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/S0140-6736(72)90985-3","article-title":"Immunoregulation oncogenic viruses and malignant lymphomas","volume":"1","author":"Schwartz, R.S.","year":"1972","unstructured":"Schwartz, R. S. (1972). Immunoregulation oncogenic viruses and malignant lymphomas. Lancet, 1, 1266-1269.","journal-title":"Lancet"},{"key":"ref_19","first-page":"27","article-title":"Origin and molecular size of Immunoglobulin-A in the mesenteric lymph of the dog","volume":"18","author":"Vaerman, J.P.; Heremans, J.F.","year":"1970","unstructured":"Vaerman, J. P., and Heremans, J. F. (1970). Origin and molecular size of Immunoglobulin-A in the mesenteric lymph of the dog. Immunology, 18, 27-38.","journal-title":"Immunology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.15.6.458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:00:42Z","timestamp":1765638042000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.15.6.458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,6]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1974,6,1]]},"published-print":{"date-parts":[[1974,6]]}},"alternative-id":["10.1136\/gut.15.6.458"],"URL":"https:\/\/doi.org\/10.1136\/gut.15.6.458","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1974,6]]}}}