{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T09:04:32Z","timestamp":1765011872050,"version":"3.46.0"},"reference-count":7,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1974,7]]},"abstract":"<jats:p>Hepatic lesions were studied for the first time in 13 cases of boutonneuse fever (Mediterranean exanthematous fever). The glutamic-oxalacetic transaminases were raised in eight patients, the glutamic-pyruvic transaminases showed an increase in 10 patients, alkaline phosphatases in seven of the 10 patients investigated, and conjugate bilirubin showed moderate increases in three patients. Five patients were studied histologically; this study showed lesions of a granulomatous type, similar to those described in Q fever, in three patients, fatty degeneration with marked alcoholism in another patient, and a normal liver in the last patient. Two of the three patients with granulomatous lesions showed a moderate increase in alkaline phosphatases. After this report boutonneuse fever must be included among the infectious conditions that can produce granulomas within the liver.<\/jats:p>","DOI":"10.1136\/gut.15.7.549","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"549-551","source":"Crossref","is-referenced-by-count":21,"title":["The liver in boutonneuse fever"],"prefix":"10.1136","volume":"15","author":[{"given":"J.","family":"Guardia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Mart\u00ednez-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Moragas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Rey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Vilaseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tornos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Beltr\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bacard\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1974,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/archinte.1965.03870040005003","article-title":"The liver lesion in Q fever","volume":"116","author":"Bernstein, M.; Edmondson, H.A.; Barbour, B.H.","year":"1965","unstructured":"Bernstein, M., Edmondson, H. A., and Barbour, B. H. (1965). The liver lesion in Q fever. Arch. intern. Med., 116, 491-498.","journal-title":"Arch. intern. Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.7326\/0003-4819-74-2-198","article-title":"Q fever hepatitis","volume":"74","author":"Dupont, H.L.; Hornick, R.B.; Levin, H.S.; Rapoport, M.I.; Woodward, T.E.","year":"1971","unstructured":"Dupont, H. L., Hornick, R. B., Levin, H. S., Rapoport, M. I., and Woodward, T. E. (1971). Q fever hepatitis. Ann. intern. Med., 74, 198-206.","journal-title":"Ann. intern. Med"},{"key":"ref_3","first-page":"1019","article-title":"Reactions biologiques, test sp6cifiques permettant le diagnostic des atteintes vasculaires dues a des rickettsies ou i des 6l6ments i leur limite (n6orickettsies)","volume":"65","author":"Giroud, P.","year":"1957","unstructured":"Giroud, P. (1957). Reactions biologiques, test sp6cifiques permettant le diagnostic des atteintes vasculaires dues a des rickettsies ou i des 6l6ments i leur limite (n6orickettsies). Presse med., 65, 1019.","journal-title":"Presse med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1001\/archinte.1970.00310050117015","article-title":"Rocky Mountain spotted fever: a vascular disease","volume":"125","author":"Hand, W.L.; Miller, J.B.; Reinarz, J.A.; Sanford, J.P.","year":"1970","unstructured":"Hand, W. L., Miller, J. B., Reinarz, J. A., and Sanford, J. P. (1970). Rocky Mountain spotted fever: a vascular disease. Arch. ternin. Med., 125, 879-882.","journal-title":"Arch. ternin. Med"},{"key":"ref_5","first-page":"2622","article-title":"Rickettsioses pleuro-pulmonaires (Letter)","volume":"1","author":"Lemenager, J.; Morel, C.; Benard, Y.; Freymuth, F.","year":"1972","unstructured":"Lemenager, J., Morel, C., Benard, Y., and Freymuth, F. (1972). Rickettsioses pleuro-pulmonaires (Letter). Nouv. Presse med., 1, 2622.","journal-title":"Nouv. Presse med"},{"key":"ref_6","first-page":"1","article-title":"Fiebre exantematica mediterrinea","volume":"5","author":"Pedro-Pons, A.","year":"1945","unstructured":"Pedro-Pons, A. (1945). Fiebre exantematica mediterrinea. Med. clin. (Barcelona), 5, 1-6.","journal-title":"Med. clin. (Barcelona)"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.7326\/0003-4819-53-5-1065","article-title":"Q fever associated with granulomatous hepatitis","volume":"53","author":"Picchi, J.; Nelson, A.R.; Waller, E.E.; Razavi, M.; Clizer, M.D.","year":"1960","unstructured":"Picchi, J., Nelson, A. R., Waller, E. E., Razavi, M., and Clizer, M. D. (1960). Q fever associated with granulomatous hepatitis. Ann. intern. Med., 53, 1065-1074.","journal-title":"Ann. intern. 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