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Likewise, the mean grade of necrosis correlated reasonably well with the serum enzyme levels in the recovery phase at 36 and 72 hours, although the transaminase level for a given degree of necrosis was considerably lower at 72 hours than at 24 hours. These findings suggest that serum transaminase levels gives a reliable indication of the severity of hepatic necrosis if the time of ingestion of the paracetamol is known and taken into account.<\/jats:p>","DOI":"10.1136\/gut.16.10.800","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"800-807","source":"Crossref","is-referenced-by-count":21,"title":["Serum transaminase levels after experimental paracetamol-induced hepatic necrosis."],"prefix":"10.1136","volume":"16","author":[{"given":"M F","family":"Dixon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Fulker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B E","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Kelleher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M S","family":"Losowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/path.1711060304","article-title":"Influence of cold environment on hepatic changes produced by repeated doses of carbon tetrachloride","volume":"106","author":"Adam, S.E.I.; Thorpe, E.","year":"1972","unstructured":"Adam, S. 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F., and Prescott, L. F. (1973). Effects of mepyramine, promethazine and hydrocortisone on paracetamolinduced hepatic necrosis in the rat. Clin. Toxicol., 6, 75-81.","journal-title":"Clin. Toxicol"},{"key":"ref_25","first-page":"597","article-title":"Hepatic drug reactions","volume":"4","author":"Perez, V.; Schaffner, F.; Popper, H.","year":"1972","unstructured":"Perez, V., Schaffner, F., and Popper, H. (1972). Hepatic drug reactions. Progr. Liver Dis,, 4, 597-625.","journal-title":"Progr. Liver Dis"},{"key":"ref_26","first-page":"519","article-title":"Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage","volume":"1","author":"Prescott, L.F.; Wright, N.; Roscoe, P.; Brown, S.S.","year":"1971","unstructured":"Prescott, L. F., Wright, N., Roscoe, P., and Brown, S. S. (1971). Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. 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