{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:48:25Z","timestamp":1765075705721,"version":"3.46.0"},"reference-count":18,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1975,3]]},"abstract":"<jats:p>Electron microscopy of hepatic tissue obtained by percutaneous needle  biopsy from nine patients with Gilbert's syndrome has revealed in every case gross hypertrophy of hepatocyte agranular endoplasmic reticulum but no other important abnormality. While this may have relevance to impairment of microsomal enzyme activity controlling bilirubin conjugation within liver cells, the serum bilirubin levels in all nine patients were below that normally associated with demonstrable UDP-glucuronyl transferase deficiency. Gross hypertrophy of agranular endoplasmic reticulum may be, therefore, a constant feature of this form of Gilbert's syndrome and may have some diagnostic value in the investigation of unconjugated hyperbilirubinaemia.<\/jats:p>","DOI":"10.1136\/gut.16.3.220","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"220-224","source":"Crossref","is-referenced-by-count":8,"title":["Liver ultrastructure in Gilbert's syndrome."],"prefix":"10.1136","volume":"16","author":[{"given":"J O","family":"McGee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J G","family":"Allan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R I","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Patrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1172\/JCI104682","article-title":"Chronic unconjugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults","volume":"41","author":"Arias, I.M.","year":"1962","unstructured":"Arias, I. 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Med"},{"key":"ref_5","first-page":"245","article-title":"Defects in hepatic transport of bilirubin in congenital hyperbilirubinemia: an analysis of plasma bilirubin disappearance curves","volume":"27","author":"Billing, B.H.; Williams, R.; Richards, T.G.","year":"1964","unstructured":"Billing, B. H., Williams, R., and Richards, T. G. (1964). Defects in hepatic transport of bilirubin in congenital hyperbilirubinemia: an analysis of plasma bilirubin disappearance curves. Clin. Sci., 27, 245-257.","journal-title":"Clin. Sci"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1056\/NEJM196906052802303","article-title":"Hepatic bilirubin UDP-glucuronyl transferase activity in liver disease and Gilbert's syndrome","volume":"280","author":"Black, M.; Billing, B.H.","year":"1969","unstructured":"Black, M., and Billing, B. H. (1969). Hepatic bilirubin UDP-glucuronyl transferase activity in liver disease and Gilbert's syndrome. New Enrl. J. 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Med"},{"key":"ref_11","first-page":"1102","article-title":"Les icteres idiopathiques chroniques: 6tude ultrastructurale et remarques pathog6niques","volume":"97","author":"Magnenat, P.; Paluello, F.M.","year":"1967","unstructured":"Magnenat, P., and Paluello, F. M. (1967). Les icteres idiopathiques chroniques: 6tude ultrastructurale et remarques pathog6niques. Schweiz. med. Wschr., 97, 1102-1105.","journal-title":"Schweiz. med. Wschr"},{"key":"ref_12","first-page":"162","article-title":"The DubinJohnson syndrome: an electron microscopic study of the liver cell","volume":"14","author":"Muscatello, U.; Mussini, I.; Agnolucci, M.T.","year":"1967","unstructured":"Muscatello, U., Mussini, I., and Agnolucci, M. T. (1967). The DubinJohnson syndrome: an electron microscopic study of the liver cell. Acta hepato-splenol. (Stuttg.), 14, 162-170.","journal-title":"Acta hepato-splenol. 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