{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T22:09:23Z","timestamp":1765663763294,"version":"3.48.0"},"reference-count":25,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1975,4]]},"abstract":"<jats:p>The transmucosal electrical potential difference (pd) and the sodium and potassium net fluxes were measured in the rectum of subjects taking carbenoxolone. There was a rise in transmucosal pd persisting throughout treatment in all subjects which was accompanied by an increase in sodium absorption and potassium secretion. Comparison of the pd changes produced by carbenoxolone with those due to the mineralocorticoid 9-alpha-fluorocortisol showed that carbenoxolone had about 1\/1000th the potency on a weight basis and the two drugs appeared to be additive in their effects. Topical instillation of carbenoxolone into the rectum produced an elevation of pd which persisted for three days. Amiloride and bendrofluazide did not interfere with these actions of carbenoxolone but spironolactone abolished them. One patient who developed fluid retention and hypokalaemia had a rectal pd similar to that of the other patients who had no side effects.<\/jats:p>","DOI":"10.1136\/gut.16.4.277","type":"journal-article","created":{"date-parts":[[2007,9,7]],"date-time":"2007-09-07T21:05:42Z","timestamp":1189199142000},"page":"277-284","source":"Crossref","is-referenced-by-count":14,"title":["Electrical potential difference, sodium absorption and potassium secretion by the human rectum during carbenoxolone therapy."],"prefix":"10.1136","volume":"16","author":[{"given":"A M","family":"Tomkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C J","family":"Edmonds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,4,1]]},"reference":[{"key":"ref_1","first-page":"243","article-title":"A new guanidine diuretic, amipramizide: reduction of the kaliuretic effect of ethacrynic acid in man","volume":"8","author":"Alter, S.; Cushman, P.; Hilton, J.G.","year":"1967","unstructured":"Alter, S., Cushman, P., and Hilton, J. G. (1967). A new guanidine diuretic, amipramizide: reduction of the kaliuretic effect of ethacrynic acid in man. Clin. Pharmacol., 8, 243-248.","journal-title":"Clin. Pharmacol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/gut.13.7.559","article-title":"Effect of luminal ions on the transepithelial potential difference of human rectum","volume":"13","author":"Archampong, E.Q.; Edmonds, C.J.","year":"1972","unstructured":"Archampong, E. Q., and Edmonds, C. J. (1972). Effect of luminal ions on the transepithelial potential difference of human rectum. Gut, 13, 559-565.","journal-title":"Gut"},{"key":"ref_3","article-title":"A K+-sparing natriuretic pyrazinamide derivative","volume":"25","author":"Baer, J.E.; Mucha, C.M.; Spitzer, S.A.; Yee, H.W.A.","year":"1966","unstructured":"Baer, J. E., Mucha, C. M., Spitzer, S. A., and Yee, H. W. A. (1966). A K+-sparing natriuretic pyrazinamide derivative. (Abstr.) Fed. Proc., 25, 197.","journal-title":"(Abstr.) Fed. Proc"},{"key":"ref_4","first-page":"127157","volume-title":"Metabolic studies of carbenoxolone sodium as biogastrone or duogastrone in patients with peptic ulcer. In A Symposium on Carbenoxolone Sodium","author":"Baron, J.H.; Nabarro, J.D.N.","year":"1968","unstructured":"Baron, J. H., and Nabarro, J. D. N. (1968). Metabolic studies of carbenoxolone sodium as biogastrone or duogastrone in patients with peptic ulcer. In A Symposium on Carbenoxolone Sodium, edited by J. M. Robson and F. M. Sullivan, pp. 127157. Butterworths, London."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S0140-6736(73)92525-7","article-title":"Mineralocorticoids and rectal potential difference","volume":"2","author":"Beevers, D.G.","year":"1973","unstructured":"Beevers, D. G. (1973). Mineralocorticoids and rectal potential difference. 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Res"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/gut.12.5.356","article-title":"Absorption of sodium and water by human rectum measured by a dialysis method","volume":"12","author":"Edmonds, C.J.","year":"1971","unstructured":"Edmonds, C. J. (1971). Absorption of sodium and water by human rectum measured by a dialysis method. Gut, 12, 356-362.","journal-title":"Gut"},{"key":"ref_13","article-title":"Effect of aldosterone on mammalian intestine","author":"Edmonds, C.J.","year":"1972","unstructured":"Edmonds, C. J. (1972). Effect of aldosterone on mammalian intestine."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/gut.11.4.330","article-title":"Measurement of electrical potentials of the human rectum and pelvic colon in normal and aldosterone-treated patients","volume":"11","author":"Edmonds, C.J.; Godfrey, R.C.","year":"1970","unstructured":"Edmonds, C. J., and Godfrey, R. C. (1970). 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Butterworths, London."},{"key":"ref_21","first-page":"262","article-title":"Effects of a new diuretic, amipramidine (MK870), in patients with cirrhosis and ascites","volume":"14","author":"Reynolds, T.B.; Pelle, H.C.","year":"1966","unstructured":"Reynolds, T. B., and Pelle, H. C. (1966). Effects of a new diuretic, amipramidine (MK870), in patients with cirrhosis and ascites. Clin. Res., 14, 262.","journal-title":"Clin. Res"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0140-6736(69)91480-9","article-title":"Clinical investigation of the effects of adrenal corticosteroid excess on the colon","volume":"1","author":"Richards, P.","year":"1969","unstructured":"Richards, P. (1969). Clinical investigation of the effects of adrenal corticosteroid excess on the colon. 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