{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:37:10Z","timestamp":1790833030535,"version":"4.1.0"},"reference-count":14,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1975,5]]},"abstract":"<jats:p>It has been suggested that an intact vagal supply is essential for the normal function of the recptors in the duodenum and proximal small bowel, which influence the rate of gastric emptying. This paper reports the effect of vagal denervation on gastric emptying and also examines the site and mode of action of receptors in the proximal small bowel.It has been demonstrated in the dog that most, if not all, the receptors controlling gastric emptying lie in the proximal 50 cm of the small bowel. Following truncal vagotomy the emptying time of each instillation increased significantly and the differential rate of emptying of different instillations remained unchanged. The proximal 50 cm of small bowel was capable to differentiating between different instillates even after selective extragastric vagotomy, in which the duodenum was vagally denervated and, therefore, duodenal braking receptors function independently of vagal innervation.<\/jats:p>","DOI":"10.1136\/gut.16.5.331","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"331-336","source":"Crossref","is-referenced-by-count":44,"title":["The vagus, the duodenal brake, and gastric emptying."],"prefix":"10.1136","volume":"16","author":[{"given":"M","family":"Shahidullah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T L","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T G","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1975,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF02235953","article-title":"Gastric secretion and emptying before and after vagotomy and pyloroplasty, with and without continuous infusion of peptavlon pentagastrin","volume":"14","author":"Aylett, P.; Wastell, C.; Wise, I.","year":"1969","unstructured":"Aylett, P., Wastell, C., and Wise, I. (1969). Gastric secretion and emptying before and after vagotomy and pyloroplasty, with and without continuous infusion of peptavlon pentagastrin. Amer. J. dig. Dis., 14, 245-252.","journal-title":"Amer. J. dig. Dis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/gut.8.2.137","article-title":"Effects of gastric surgery upon gastric emptying in cases of peptic ulceration","volume":"8","author":"Buckler, K.G.","year":"1967","unstructured":"Buckler, K. G. (1967). Effects of gastric surgery upon gastric emptying in cases of peptic ulceration. Gut, 8, 137-147.","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/jama.1951.02920290021005","article-title":"Appraisal of va-otomy for peptic ulcer after seven years","volume":"145","author":"Dragstedt, L.R.; Woodward, E.R.","year":"1951","unstructured":"Dragstedt, L. R., and Woodward, E. R. (1951). Appraisal of va-otomy for peptic ulcer after seven years. J. 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J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1113\/jphysiol.1951.sp004562","article-title":"Pattern of emptying of human stomach","volume":"113","author":"Hunt, J.N.; Spurrell, W.R.","year":"1951","unstructured":"Hunt, J. N., and Spurrell, W. R. (1951). Pattern of emptying of human stomach. J. Physiol. (Lond.), 113, 157-168.","journal-title":"J. Physiol. (Lond.)"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1136\/bmj.1.5020.681","article-title":"Influence of hydrochloric acid on gastric secretion and emptying in patients with duodenal ulcer","volume":"1","author":"Hunt, J.N.","year":"1957","unstructured":"Hunt, J. N. (1957). Influence of hydrochloric acid on gastric secretion and emptying in patients with duodenal ulcer. Brit. med. J., 1, 681-684.","journal-title":"Brit. med. 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Roentgenol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/bjs.1800571012","article-title":"Gastric incontinence and post-vagotomy diarrhoea","volume":"57","author":"McKelvey, S.T.D.","year":"1970","unstructured":"McKelvey, S. T. D. (1970). Gastric incontinence and post-vagotomy diarrhoea. Brit. J. Surg., 57, 741-747.","journal-title":"Brit. J. Surg"},{"key":"ref_13","first-page":"99","article-title":"El ritmo de apertura pilorica en el ulcus gastroduodenal","volume":"12","author":"Tamarit Torres, J.; Enriquez de Salamanca, Jr., F.; CastroRial Canosa, M.","year":"1954","unstructured":"Tamarit Torres, J., Enriquez de Salamanca, F., Jr., and CastroRial Canosa, M. (1954). El ritmo de apertura pilorica en el ulcus gastroduodenal. Arch. Med. exp. (Madr.), 12, 99-118.","journal-title":"Arch. Med. exp. 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