{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T11:27:02Z","timestamp":1765625222272,"version":"3.48.0"},"reference-count":16,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1975,7]]},"abstract":"<jats:p>The ability of patients with coeliac disease to produce primary and secondary antibody in response to a new antigen has been tested. Eight patients with coeliac disease were injected intravenously with the coliphage phiX 174. Antibody levels were measured throughout the primary response. On day 28 a second injection was given and the secondary response was also studied in detail. The production of antibody in the primary response is lower than in a group of normal subjects. The secondary response is severely reduced and the difference between the coeliac group and controls is highly significant. The secondary response in the coeliac patients contains a much higher proportion of IgM antibody than normal. These abnormalities correlate approximately with clinical status and with hyposplenism. It is concluded that in patients with coeliac disease the ability to produce antibody is impaired, with a defect in switching from IgM to IgG antibody.<\/jats:p>","DOI":"10.1136\/gut.16.7.538","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"538-542","source":"Crossref","is-referenced-by-count":24,"title":["The immune response of phiX 174 in man. III. Evidence for an association between hyposplenism and immunodeficiency in patients with coeliac disease."],"prefix":"10.1136","volume":"16","author":[{"given":"P G","family":"Baker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J V","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D B","family":"Peacock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A E","family":"Read","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1975,7,1]]},"reference":[{"key":"ref_1","first-page":"129131","article-title":"Serum immunoglobulins in adult coeliac disease","volume":"2","author":"Asquith, P.; Thompson, R.A.; Cooke, W.T.","year":"1969","unstructured":"Asquith, P., Thompson, R. A., and Cooke, W. T. (1969). 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Dis"},{"key":"ref_5","article-title":"Coeliac Society List of Gluten Free Foods, 1972-3","author":"Colman, J.","year":"1972","unstructured":"Colman, J. (1972). Coeliac Society List of Gluten Free Foods, 1972-3. Sydney Press, Bedford."},{"key":"ref_6","first-page":"59","article-title":"Immunochemical studies of the serum, intestinal secretions and intestinal mucosa in patients with adult celiac disease and other forms ofthe celiac syndrome","author":"Douglas, A.P.; Crabbe, P.A.; Hobbs, J.R.","year":"1970","unstructured":"Douglas, A. P., Crabbe, P. A., and Hobbs, J. R. (1970). Immunochemical studies of the serum, intestinal secretions and intestinal mucosa in patients with adult celiac disease and other forms ofthe celiac syndrome. Gastroenterology, 59,414-425.","journal-title":"Gastroenterology"},{"key":"ref_7","first-page":"388","article-title":"Om sprue och mjaltatrofi","volume":"1","author":"Engel, A.","year":"1939","unstructured":"Engel, A. (1939). Om sprue och mjaltatrofi. Nord. 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