{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:36:35Z","timestamp":1787016995202,"version":"build-2736575974"},"reference-count":14,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1976,1]]},"abstract":"<jats:p>One gram N-benzoyl-L-tyrosyl PABA was orally administered to 24 controls, 15 patients with chronic exocrine pancreatic disease, 13 patients after an attack of acute pancreatitis, two patients with gluten-sensitive enteropathy, and 10 patients with biliary tract disease, peptic ulcer, or other pathology of the gastrointestinal tract. In the presence of chymotrypsin, PABA is split from the peptide and excreted in the urine. The amount of PABA excreted serves as a parameter of exocrine pancreatic function. In 51 patients, exocrine pancreatic secretion was also assessed by the Lundh test. In the control group a mean of 59-6 +\/- 12-2% (mean +\/- 2 SD) of the peptide-PABA was excreted over a period of six hours. PABA excretion in exocrine pancreatic deficiency was significantly less (P less than 0.001) than in controls. With one exception no overlap of data was noted. In the group with exocrine pancreatic deficiency, a significant relationship was shown between the PFT and the Lundh test. Reproducibility in duplicate test was excellent. The present data justify further investigations of this procedure as a possible new oral test of exocrine pancreatic function.<\/jats:p>","DOI":"10.1136\/gut.17.1.27","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"27-32","source":"Crossref","is-referenced-by-count":79,"title":["Oral administration of a chymotrypsin-labile peptide--a new test of exocrine pancreatic function in man (PFT)."],"prefix":"10.1136","volume":"17","author":[{"given":"K","family":"Gyr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G A","family":"Stalder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Schiffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Fehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Vonderschmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Fahrlaender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1976,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1055\/s-0028-1107221","article-title":"Die Pankreasfunktionspruefung mit dem LundhTest","volume":"98","author":"Aenishaenslin, W.H.; Kayasseh, L.; Stalder, G.A.","year":"1973","unstructured":"Aenishaenslin, W. H., Kayasseh, L., and Stalder, G. A. (1973). Die Pankreasfunktionspruefung mit dem LundhTest. Deutsche Medizinische Wochenschrift, 98, 2192-2196.","journal-title":"Deutsche Medizinische Wochenschrift"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/gut.1.2.111","article-title":"A test of pancreatic function in man based on the analysis of duodenal contents after administration of secretin and pancreozymin","volume":"1","author":"Burton, P.; Evans, D.G.; Harper, A.A.; Howat, H.T.; Oleesky, S.; Scott, J.; Varley, H.","year":"1960","unstructured":"Burton, P., Evans, D. G., Harper, A. A., Howat, H. T., Oleesky, S., Scott, J., and Varley, H. (1960). A test of pancreatic function in man based on the analysis of duodenal contents after administration of secretin and pancreozymin. Gut, 1, 111-124.","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1021\/jm00281a002","article-title":"New substrates for a pancraetic exocrine function test","volume":"15","author":"De Benneville, R.L.; Godfrey, J.W.; Sims, H.J.; Imondi, A.R.","year":"1972","unstructured":"De Benneville, R. L., Godfrey, J. W., Sims, H. J., and Imondi, A. R. (1972). New substrates for a pancraetic exocrine function test. Journal of Medical Chemistry, 15, 1098-1100.","journal-title":"Journal of Medical Chemistry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1172\/JCI102332","article-title":"Studies in paraaminohippuric acid synthesis in the human: its application as a liver function test","volume":"29","author":"Deiss, W.P.; Cohen, Ph P.","year":"1950","unstructured":"Deiss, W. P., and Cohen, Ph. P. (1950). Studies in paraaminohippuric acid synthesis in the human: its application as a liver function test. 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American Journal of Digestive Diseases, 20, 506-512.","journal-title":"American Journal of Digestive Diseases"},{"key":"ref_7","first-page":"68","article-title":"Exocrine pancreatic function in protein deficient patas monkeys studied by means of a test meal and an indirect pancreatic function test (PFT)","year":"1975","unstructured":"Gyr, K., Wolf, R. H., Imondi, A. R., and Felsenfeld, 0. (1975). Exocrine pancreatic function in protein deficient patas monkeys studied by means of a test meal and an indirect pancreatic function test (PFT). Gastroenterology, 68,488-494.","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1136\/gut.13.9.726","article-title":"Synthetic peptides in the diagnosis of exocrine pancreatic insufficiency in animals","volume":"13","author":"Imondi, A.R.; Stradley, R.P.; Wohlgemuth, R.L.","year":"1972","unstructured":"Imondi, A. R., Stradley, R. P., and Wohlgemuth, R. L. (1972). Synthetic peptides in the diagnosis of exocrine pancreatic insufficiency in animals. Gut, 13, 726-731.","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0016-5085(62)80025-0","article-title":"Pancreatic exocrine function in neoplastic and inflammatory disease: a simple and reliable new test","volume":"42","author":"Lundh, G.","year":"1962","unstructured":"Lundh, G. (1962). Pancreatic exocrine function in neoplastic and inflammatory disease: a simple and reliable new test. Gastroenterology, 42, 275-280.","journal-title":"Gastroenterology"},{"key":"ref_10","first-page":"835","article-title":"The Lundh test in the diagnosis of pancreatic disease: a review of five years'","volume":"14","author":"Mottaleb, A.; Kapp, F.; Noguera, E.C.A.; Kellock, T.D.; Wiggins, H.S.; Waller, S.L.","year":"1973","unstructured":"Mottaleb, A., Kapp, F., Noguera, E. C. A., Kellock, T. D., Wiggins, H. S., and Waller, S. L. (1973). 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