{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:59:23Z","timestamp":1790564363516,"version":"4.1.0"},"reference-count":37,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1976,11]]},"abstract":"<jats:p>Histocompatibility (HLA) antigen phenotypes have been studied in 100 patients with ulcerative colitis, 100 with Crohn's disease, and 283 normal controls. In addition the incidence of ankylosing spondylitis, sacroiliitis, and \"enteropathic\" peripheral arthropathy was determined in the patients with inflammatory bowel disease (IBD). There was no significant difference in antigen frequency between patients and controls. However, the incidence of HLA-B27 was increased in the patients complicated by ankylosing spondylitis and\/or sacroiliitis in both ulcerative colitis and Crohn's disease. In contrast, none of the 29 IBD patients with \"enteropathic\" peripheral arthropathy had B27 antigen. Furthermore, ankylosing spondylitis was found more frequently in ulcerative colitis bearing HLA-B27 compared with non-B27 patients (P less than 0-01). The same was found in Crohn's disease, although this difference was not statistically significant. In addition, 12 of 14 ulcerative colitis patients and five out of six Crohn's patients with HLA-B27 had total colitis, compared with the frequency of total colitis in non-B27 patients (P less than 0-024 and less than 0-03 respectively). The data suggest that B27 histocompatibility antigen could be a pathogenetic discriminator between the  arthropathies in IBD and may be of prognostic significance with respect to extension and severity of the disease.<\/jats:p>","DOI":"10.1136\/gut.17.11.906","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"906-910","source":"Crossref","is-referenced-by-count":93,"title":["Histocompatibility antigens in inflammatory bowel disease. Their clinical significance and their association with arthropathy with special reference to HLA-B27 (W27)."],"prefix":"10.1136","volume":"17","author":[{"given":"E G","family":"Mallas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Mackintosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Asquith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W T","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1976,11,1]]},"reference":[{"key":"ref_1","article-title":"B27 positive Crohn's disease","year":"1974","unstructured":"%B27 positive Crohn's disease Jacoby et al. (1974)","journal-title":"Jacoby et al"},{"key":"ref_2","author":"Nagant","year":"1974","unstructured":"Nagant et al. (1974)"},{"key":"ref_3","author":"Russell","year":"1975","unstructured":"Russell et al. (1975)"},{"key":"ref_4","author":"Morris","year":"1974","unstructured":"Morris et al. (1974)"},{"key":"ref_5","author":"Brewerton","year":"1974","unstructured":"Brewerton et al. (1974)t"},{"key":"ref_6","article-title":"noted three out of six patients with Crohn's disease and B27 had colonic involvement, compared with 16 out of 68 B27 negative, though in that instance the findings were not statistically significant. Nevertheless, it would appear the antigen B27 may have some influence on the severity and location of the inflammatory bowel disease","unstructured":"noted three out of six patients with Crohn's disease and B27 had colonic involvement, compared with 16 out of 68 B27 negative, though in that instance the findings were not statistically significant. Nevertheless, it would appear the antigen B27 may have some influence on the severity and location of the inflammatory bowel disease."},{"key":"ref_7","first-page":"489","article-title":"An association between ulcerative colitis, regional enteritis, and ankylosing spondylitis","volume":"29","author":"Acheson, E.D.","year":"1960","unstructured":"Acheson, E. D. (1960). An association between ulcerative colitis, regional enteritis, and ankylosing spondylitis. Quarterly Journal of Medicine, 29, 489-499.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_8","first-page":"157","article-title":"HLA-A antigen 27 and reactive arthritis","volume":"2","author":"Aho, K.; Ahvonew, P.; Lassus, A.; Sievers, K.; Tiilikainen, A.","year":"1973","unstructured":"Aho, K., Ahvonew, P., Lassus, A., Sievers, K., and Tiilikainen, A. (1973). HLA-A antigen 27 and reactive arthritis. (Letter.) Lancet, 2, 157.","journal-title":"(Letter.) Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1136\/ard.23.1.64","article-title":"Arthritic manifestations in regional enteritis","volume":"23","author":"Ansell, B.M.; Wigley, R.A.D.","year":"1964","unstructured":"Ansell, B. M., and Wigley, R. A. D. (1964). Arthritic manifestations in regional enteritis. Annals of Rheumatic Disease, 23, 64.","journal-title":"Annals of Rheumatic Disease"},{"key":"ref_10","first-page":"113115","article-title":"Histocompatibility antigens in patients with inflammatory-bowel disease","volume":"1","author":"Asquith, P.; Mackintosh, P.; Stokes, P.L.; Holmes, G.K.T.; Cooke, W.T.","year":"1974","unstructured":"Asquith, P., Mackintosh, P., Stokes, P. L., Holmes, G. K. T., and Cooke, W. T. (1974). Histocompatibility antigens in patients with inflammatory-bowel disease. Lancet, 1, 113115.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0025-7125(16)33347-8","article-title":"The arthritis of ulcerative colitis and regional enteritis ('intestinal arthritis')","volume":"49","author":"Bowen, G.E.; Kirsner, J.B.","year":"1965","unstructured":"Bowen, G. E., and Kirsner, J. B. (1965). The arthritis of ulcerative colitis and regional enteritis ('intestinal arthritis'). Medical Clinics of North America, 49, 17-32.","journal-title":"Medical Clinics of North America"},{"key":"ref_12","first-page":"904","article-title":"Ankylosing spondylitis and HL-A 27","volume":"1","author":"Brewerton, D.A.; Caffrey, M.; Hart, F.D.; James, D.C.O.; Nicholls, A.; Sturrock, R.D.","year":"1973","unstructured":"Brewerton, D. A., Caffrey, M., Hart, F. D., James, D. C. O., Nicholls, A., and Sturrock, R. D. (1973). Ankylosing spondylitis and HL-A 27. Lancet, 1, 904-907.","journal-title":"Lancet"},{"key":"ref_13","first-page":"956958","article-title":"HL-A 27 and arthropathies associated with ulcerative colitis and psoriasis","volume":"0","author":"Brewerton, D.A.; Caffrey, M.; Nicholls, A.Walters; D.; James, D.C.","year":"1974","unstructured":"Brewerton, D. A., Caffrey, M., Nicholls, A.. Walters, D., and James, D. C. 0 (1974). HL-A 27 and arthropathies associated with ulcerative colitis and psoriasis. Lancet, 1, 956958.","journal-title":"Lancet"},{"key":"ref_14","first-page":"996","volume":"2","year":"1973","unstructured":"Brewerton, D. A., Caffrey, M., Nicholls, A., Walters, D., Oates, J. K., and James, D. C. 0. (1973). Reiter's disease and HL-A 27. Lancet, 2, 996-998.","journal-title":"Reiter's disease and HL-A 27. Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0090-1229(74)90029-4","article-title":"The association of HL-A antigens with diseases","volume":"3","author":"Dausset, J.; Degos, L.; Hors, J.","year":"1974","unstructured":"Dausset, J., Degos, L., and Hors, J. (1974). The association of HL-A antigens with diseases. Clinical Immunology and Immunopathology, 3, 127-149.","journal-title":"Clinical Immunology and Immunopathology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1744-313X.1974.tb00312.x","article-title":"HL-A and disease. The detection of associations","volume":"1","author":"Edwards, J.H.","year":"1974","unstructured":"Edwards, J. H. (1974). HL-A and disease. The detection of associations. Journal of Inmmunogenetics, 1, 249-257.","journal-title":"Journal of Inmmunogenetics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/gut.13.6.438","article-title":"Human leucocyte antigens in Crohn's disease and ulcerative colitis","volume":"13","author":"Gleeson, M.H.; Walker, J.S.; Wentzel, J.; Chapman, J.A.; Harris, R.","year":"1972","unstructured":"Gleeson, M. H., Walker, J. S., Wentzel, J., Chapman, J. A., and Harris, R. (1972). Human leucocyte antigens in Crohn's disease and ulcerative colitis. Gut, 13, 438-440.","journal-title":"Gut"},{"key":"ref_18","article-title":"Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus","year":"1971","unstructured":"Grumet, F. C., Coukell, A., Bodmer, J. G., Bodmer, W. F., and McDevitt, H. 0. (1971). Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus."},{"key":"ref_19","first-page":"193","article-title":"New England","volume":"285","unstructured":"New England Journal of Medicine, 285, 193-196.","journal-title":"Journal of Medicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00005792-197305000-00003","article-title":"The musculo-skeletal complications of Crohn's disease","volume":"52","author":"Haslock, I.; Wright, V.","year":"1973","unstructured":"Haslock, I., and Wright, V. (1973). The musculo-skeletal complications of Crohn's disease. Medicine, 52, 217-225.","journal-title":"Medicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1136\/ard.33.5.422","article-title":"HL-A 27 in Crohn's disease","volume":"33","author":"Jacoby, R.K.; Jayson, M.I.V.","year":"1974","unstructured":"Jacoby, R. K., and Jayson, M. I. V. (1974). HL-A 27 in Crohn's disease. Annals of Rheumatism, 33, 422-424.","journal-title":"Annals of Rheumatism"},{"key":"ref_22","first-page":"291","article-title":"Diagnostic criteria for population studies","volume":"13","author":"Kellgren, J.H.","year":"1962","unstructured":"Kellgren, J. H. (1962). Diagnostic criteria for population studies. Bulletin of Rheumnatic Diseases, 13, 291-292.","journal-title":"Bulletin of Rheumnatic Diseases"},{"key":"ref_23","article-title":"Immunological apparatus of the gut and inflammatory bowel disease","author":"Kraft, S.C.; Kirsner, J.B.","year":"1971","unstructured":"Kraft, S. C., and Kirsner, J. B. (1971). Immunological apparatus of the gut and inflammatory bowel disease."},{"key":"ref_24","first-page":"574","article-title":"HL-A antigens in inflammatory bowel disease","volume":"1","author":"Lewkonia, R.M.; Woodrow, J.C.; McConnell, R.B.; Price-Evans, D.A.","year":"1974","unstructured":"Lewkonia, R. M., Woodrow, J. C., McConnell, R. B., and Price-Evans, D. A. (1974). HL-A antigens in inflammatory bowel disease. (Letter.) Lancet, 1, 574-575.","journal-title":"(Letter.) Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0002-9343(72)90002-2","article-title":"Histocompatibility antigens, immune responsiveness and susceptibility to disease","volume":"52","author":"McDevitt, H.O.; Bodmer, W.F.","year":"1972","unstructured":"McDevitt, H. O., and Bodmer, W. F. (1972). Histocompatibility antigens, immune responsiveness and susceptibility to disease. Amnerican Journal of Medicine, 52, 1-8.","journal-title":"Amnerican Journal of Medicine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1056\/NEJM197405162902004","article-title":"HL-A-W27. A useful discriminator in the arthropathies of inflammatory bowel disease","volume":"290","author":"Morris, R.I.; Metzger, A.L.; Bluestone, R.; Terasaki, P.","year":"1974","unstructured":"Morris, R. I., Metzger, A. L., Bluestone, R., and Terasaki, P. (1974). HL-A-W27. A useful discriminator in the arthropathies of inflammatory bowel disease. New England Journal of Medicine, 290, 1117-1119.","journal-title":"New England Journal of Medicine"},{"key":"ref_27","first-page":"664","article-title":"The Radiology of Skeletal Disorders","volume":"1","author":"Murray, R.O.; Jacobson, H.G.","year":"1971","unstructured":"Murray, R. O., and Jacobson, H. G. (1971). The Radiology of Skeletal Disorders, p. 664. Churchill-Livingstone: Edinburgh. Nagant de Deuxchaisnes, C., Huaux, J. P., Fiasse, R., and de Bruyere, M. (1974). Ankylosing spondylitis, sacroiliitis, regional enteritis, and HL-A 27. (Letter.) Lancet, 1, 1238-1239.","journal-title":"(Letter.) Lancet; Ankylosing spondylitis, sacroiliitis, regional enteritis, and HL-A 27"},{"key":"ref_28","first-page":"411","article-title":"Musculoskeletal manifestations of inflammatory bowel disease; ulcerative and granulomatous colitis and ulcerative proctitis","volume":"48","author":"Palumbo, P.J.; Ward, L.E.; Sauer, W.G.; Scudamore, H.H.","year":"1973","unstructured":"Palumbo, P. J., Ward, L. E., Sauer, W. G., and Scudamore, H. H. (1973). Musculoskeletal manifestations of inflammatory bowel disease; ulcerative and granulomatous colitis and ulcerative proctitis. 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High association of an HL-A antigen, W27, with ankylosing spondylitis. New England Journal of Medicine, 288, 704-706.","journal-title":"New England Journal of Medicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0016-5085(19)34876-0","article-title":"Familial occurrence of regional enteritis and ulcerative colitis","volume":"45","author":"Sherlock, P.; Bell, B.M.; Steinberg, H.; Almy, T.P.","year":"1963","unstructured":"Sherlock, P., Bell, B. M., Steinberg, H., and Almy, T. P. (1963). Familial occurrence of regional enteritis and ulcerative colitis. Gastroenterology, 45, 413-420.","journal-title":"Gastroenterology"},{"key":"ref_33","first-page":"423","article-title":"Familial aspects of inflammatory bowel disease","volume":"61","author":"Singer, H.C.; Anderson, J.G.D.; Frischer, H.; Kirsner, J.B.","year":"1973","unstructured":"Singer, H. C., Anderson, J. G. D., Frischer, H., and Kirsner, J. B. (1973). Familial aspects of inflammatory bowel disease. Gastroenterology, 61, 423-486.","journal-title":"Gastroenterology"},{"key":"ref_34","first-page":"3","article-title":"HL-A and disease associations","volume":"22","author":"Svejgaard, A.; Platz, P.; Ryder, L.P.; Staub Nielsen, L.; Thomsen, M.","year":"1975","unstructured":"Svejgaard, A., Platz, P., Ryder, L. P., Staub Nielsen, L., and Thomsen, M. (1975). HL-A and disease associations. A survey. Transplantation Reviews, 22, 3-43.","journal-title":"A survey. Transplantation Reviews"},{"key":"ref_35","first-page":"1797","article-title":"Some speculations on the association between HL-A and disease based on studies of psoriasis patients and their families","volume":"5","author":"Svejgaard, A.; Svejgaard, E.; Staub Nielsen, L.; Jacobsen, B.","year":"1973","unstructured":"Svejgaard, A., Svejgaard, E., Staub Nielsen, L., and Jacobsen, B. (1973). Some speculations on the association between HL-A and disease based on studies of psoriasis patients and their families. Transplantation Proceedings, 5, 1797-1798.","journal-title":"Transplantation Proceedings"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/204998b0","article-title":"Microdroplet assay of human serum cytotoxins","volume":"204","author":"Terasaki, P.I.; McClelland, J.D.","year":"1964","unstructured":"Terasaki, P. I., and McClelland, J. D. (1964). Microdroplet assay of human serum cytotoxins. Nature, 204, 998-1000.","journal-title":"Nature"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0140-6736(73)92505-1","article-title":"HL-A 27 and Reiter's syndrome","volume":"2","author":"Woodrow, J.C.","year":"1973","unstructured":"Woodrow, J. C. (1973). HL-A 27 and Reiter's syndrome. (Letter.) Lancet, 2, 671-672.","journal-title":"(Letter.) 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