{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T17:04:57Z","timestamp":1768323897588,"version":"3.49.0"},"reference-count":13,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1976,12]]},"abstract":"<jats:p>The effect of motilin on lower oesophageal sphincter (LES) pressure has been studied in unanesthetised specially trained dogs using an infusion manometric technique. Motilin produced significant rises in resting pressure and contractions of the LES after doses ranging from 0-009 mug\/kg to 0-05 mug\/kg. Doses greater than 0-05 mug\/kg resulted in repetitive high amplitude contractions. Atropine 30 mug\/kg completely abolished the effect of the lower doses of motilin. Higher doses of motilin in atropinised dogs still caused a small rise in baseline pressure and contractile activity still appeared. Hexamethonium 2 mg\/kg resulted in both a diminished rise in LES pressure and the disappearance of contractions after motilin. Hexamethonium and atropine together completely abolished the LES response to motilin. We conclude that motilin increases LES pressure by acting on preganglionic cholinergic neurones to release acetylcholine which excites other cholinergic neurones supplying the circular muscle of the LES.<\/jats:p>","DOI":"10.1136\/gut.17.12.925","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"925-932","source":"Crossref","is-referenced-by-count":54,"title":["Effect of motilin on the lower oesophageal sphincter."],"prefix":"10.1136","volume":"17","author":[{"given":"A J","family":"Meissner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K L","family":"Bowes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Zwick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E E","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1976,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0016-5085(72)80145-8","article-title":"Motilin, a gastric motor activity-stmulating polypeptide: final purification, amino acid composition, and C-terminal residues","volume":"62","author":"Brown, J.C.; Cook, M.A.; Dryburgh, J.R.","year":"1972","unstructured":"Brown, J. C., Cook, M. A., and Dryburgh, J. R. (1972). Motilin, a gastric motor activity-stmulating polypeptide: final purification, amino acid composition, and C-terminal residues. Gastroenterology, 62, 401-404.","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1139\/o73-066","article-title":"Motilin, a gastric motor activity-stimulating polypeptide: the complete amino acid sequence","volume":"51","author":"Brown, J.C.; Cook, M.A.; Dryburgh, J.R.","year":"1973","unstructured":"Brown, J. C., Cook, M. A., and Dryburgh, J. R. (1973). Motilin, a gastric motor activity-stimulating polypeptide: the complete amino acid sequence. 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The further purification of motilin, a gastric motor activity stimulating polypeptide from the mucosa of the small intestine of hogs. Canadian Journal of Physiology and Pharmacology, 49, 399-405.","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1172\/JCI106512","article-title":"Hormonal regulation of human lower esophageal sphincter competence: interaction of gastrin and secretin","volume":"50","author":"Cohen, S.; Lipshutz, W.","year":"1971","unstructured":"Cohen, S., and Lipshutz, W. (1971). Hormonal regulation of human lower esophageal sphincter competence: interaction of gastrin and secretin. 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Journal of Clinical Investigation, 55, 1119-1126.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000197714","article-title":"The motor-stimulating effect of natural motilin on the lower esophageal sphincter, fundus, antrum and duodenum in dogs","volume":"13","author":"Jennewein, H.M.; Hummelt, H.; Siewert, R.; Waldeck, F.","year":"1975","unstructured":"Jennewein, H. M., Hummelt, H., Siewert, R., and Waldeck, F. (1975). The motor-stimulating effect of natural motilin on the lower esophageal sphincter, fundus, antrum and duodenum in dogs. Digestion, 13, 246-250.","journal-title":"Digestion"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0016-5085(19)33219-6","article-title":"Lower esophageal sphincter pressure changes after food ingestion","volume":"63","author":"Nebel, 0. T.; Castell, D. 0","year":"1972","unstructured":"Nebel, 0. T., and Castell, D. 0. (1972). Lower esophageal sphincter pressure changes after food ingestion. Gastroenterology, 63, 778-783.","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1152\/ajplegacy.1974.226.4.749","article-title":"Threshold curves and refractoriness properties of gastric relaxation oscillators","volume":"226","author":"Sarna, S.K.; Daniel, E.E.","year":"1974","unstructured":"Sarna, S. K., and Daniel, E. E. (1974). Threshold curves and refractoriness properties of gastric relaxation oscillators. 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