{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:37:26Z","timestamp":1765600646976,"version":"3.48.0"},"reference-count":41,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1976,2]]},"abstract":"<jats:p>Small intestinal mucosa contains both thymus dependent and thymus independent lymphoid cells and thus has the capacity to act via humoral and cellular mechanisms as a site of local immunity and local hypersensitivity. Allograft rejection of mouse small intestine is a model of a local cell mediated reaction. The effects of this clearly defined, immunologically mediated damage villi, crypts, enterocytes, and lymphoid cell infiltrate have been assessed by comparing the morphology of rejecting allografts with that of isografts and normal small intestine of the same age. In rejection there is infiltration of the lamina propria with lymphocytes, hyperplasia of the crypts of Lieberkuhn, and an eventual sloughing off of the mucosa. Usually, but not always, there is villous atrophy and increased numbers of intraepithelial lymphocytes. However, the morphology of individual enterocytes remains normal throughout rejection and neither plasma cells nor polymorphonuclear leucocytes infiltrate the lamina propria before mucosal ulceration. These results show unequivocally that a local T cell mediated immune response causes villous atrophy and crypt hyperplasia in this animal model, and since there is no evidence of local enterocyte cytotoxicity, a lymphokine may be the link between the activated T cell and the effects on mucosal architecture. We suggest that a local CMI reaction may be the cause of villous atrophy, crypt hyperplasia, and malabsorption in many clinical and experimental conditions, including coeliac disease, food allergy, and intestinal infections.<\/jats:p>","DOI":"10.1136\/gut.17.2.81","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"81-91","source":"Crossref","is-referenced-by-count":61,"title":["Hypersensitivity reactions in the small intestine. 2. Effects of allograft rejection on mucosal architecture and lymphoid cell infiltrate."],"prefix":"10.1136","volume":"17","author":[{"given":"T T","family":"MacDonald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1976,2,1]]},"reference":[{"key":"ref_1","first-page":"459","article-title":"Studies on the mechanism of the self-cure reaction in rats infected with Nippostrongylus brasiliensis","volume":"10","author":"Barth, E.E.E.; Jarrett, W.F.H.; Urquhart, G.M.","year":"1966","unstructured":"Barth, E. E. E., Jarrett, W. F. H., and Urquhart, G. M. (1966). Studies on the mechanism of the self-cure reaction in rats infected with Nippostrongylus brasiliensis. 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Intestinal phase of the runting syndrome in mice."},{"key":"ref_24","first-page":"\"104","article-title":"Observations on nutrient absorption and certain disaccharidase abnormalities","volume":"6","author":"Holmes, J.T.; Klein, M.S.; Winawer, S.J.; Fortner, J.G.","year":"1971","unstructured":"Observations on nutrient absorption and certain disaccharidase abnormalities. Transplantation, 6, 104-110. Holmes, J. T., Klein, M. S., Winawer, S. J., and Fortner, J. G. (1971). Morphological studies of rejection in canine jejunal allografts. Gastroenterology, 61, 693-706.","journal-title":"Transplantation; Morphological studies of rejection in canine jejunal allografts"},{"key":"ref_25","first-page":"53","article-title":"The immune response to nematode infections","volume":"4","author":"Jarrett, E.E.E.; Urquhart, G.M.","year":"1971","unstructured":"Jarrett, E. E. E., and Urquhart, G. M. (1971). The immune response to nematode infections. 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Immunological phenomena following gluten challenge in the jejunum of patients with adult coeliac disease and dermatitis herpetiformis. In Coeliac Disease, pp. 173-174. Edited by W. T. J. M. Hekkens and A. S. Pena. Stenfert Kroese: Leiden."},{"key":"ref_28","first-page":"2","article-title":"The coeliac philosophy","author":"Lancet","year":"1974","unstructured":"Lancet (1974). The coeliac philosophy. (Editorial). Lancet, 2,501-502.","journal-title":"(Editorial). Lancet"},{"key":"ref_29","first-page":"452","article-title":"The detection of lymphokines in rejecting allografts of foetal mouse intestine","volume":"138","author":"MacDonald, T.T.; Russell, R.J.","year":"1976","unstructured":"MacDonald, T. T., and Russell, R. J. (1976). The detection of lymphokines in rejecting allografts of foetal mouse intestine. (In preparation.) Mattioli, C. A., and Tomasi, T. B. (1976). The lifespan of IgA plasma cells from the mouse intestine. 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