{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:56:40Z","timestamp":1764997000202,"version":"3.46.0"},"reference-count":17,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1976,5]]},"abstract":"<jats:p>The proportional and absolute numbers of circulating thymus dependent lymphocytes (T cells) were reduced in untreated patients with coeliac disease but were normal after treatment with a gluten free diet. There was an inverse correlation between circulating T cell numbers and jejunal intraepithelial lymphocytes. This evidence suggests a possible role for T cells in the pathogenesis of coeliac disease and is a further example of disturbed cell mediated immunity in this condition.<\/jats:p>","DOI":"10.1136\/gut.17.5.328","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"328-331","source":"Crossref","is-referenced-by-count":22,"title":["T cell depletion in untreated adult coeliac disease."],"prefix":"10.1136","volume":"17","author":[{"given":"D P","family":"O'Donoghue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Lancaster-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Laviniere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1976,5,1]]},"reference":[{"key":"ref_1","first-page":"242","article-title":"Cell mediated immunity in coeliac disease","volume-title":"Coeliac Disease","author":"Asquith, P.","year":"1974","unstructured":"Asquith, P. (1974). Cell mediated immunity in coeliac disease. In Coeliac Disease, pp. 242-262. Edited by W. Th. Hekkens and A. S. Pena. Second International Coeliac Symposium, Leiden. Stenfert Kroese: Leiden."},{"key":"ref_2","first-page":"475","article-title":"Streatorrhoea and malignant lymphoma","volume":"12","author":"Austad, W.I.; Cornes, J.S.Gough; R., K.; McCarthy, C.F.; Read, A.E.","year":"1967","unstructured":"Austad, W. I., Cornes, J. S. Gough, K. R., McCarthy, C. F., and Read, A. E. (1967). Streatorrhoea and malignant lymphoma. American Journal of Digestive Diseases, 12, 475-490.","journal-title":"American Journal of Digestive Diseases"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/gut.10.1.57","article-title":"Serum immunoglobulins and lymphocyte transformation studies in coeliac disease","volume":"10","author":"Blecher, T.E.; Brzechaw-Ajdukiewicz, A.; McCarthy, C.F.; Read, A.E.","year":"1969","unstructured":"Blecher, T. E., Brzechaw-Ajdukiewicz, A., McCarthy, C. F., and Read, A. E. (1969). Serum immunoglobulins and lymphocyte transformation studies in coeliac disease. Gut, 10, 57-62.","journal-title":"Gut"},{"key":"ref_4","first-page":"265","volume-title":"Lymphocytes in coeliac disease. In Coeliac Disease","author":"Ferguson, A.","year":"1974","unstructured":"Ferguson, A. (1974). Lymphocytes in coeliac disease. In Coeliac Disease, pp. 265-276. Edited by W. Th. Hekkens and A. S. Pena. Second International Coeliac Symposium, Leiden. Stenfert Kroese: Leiden."},{"key":"ref_5","first-page":"15","article-title":"The jejunal cellular infiltrate in coeliac disease complicated by lymphoma., Gut","author":"Ferguson, R.; Asquith, P.; Cooke, W.T.","year":"1974","unstructured":"Ferguson, R., Asquith, P., and Cooke, W. T. (1974). The jejunal cellular infiltrate in coeliac disease complicated by lymphoma.,Gut, 15,458-461."},{"key":"ref_6","first-page":"988994","article-title":"Quantitation of intraepithelial lymphocytes in human jejunum","volume":"12","author":"Ferguson, A.; Murray, D.","year":"1971","unstructured":"Ferguson, A. and Murray, D. (1971). Quantitation of intraepithelial lymphocytes in human jejunum. Gut, 12, 988994. Harris, 0. D., Cooke, W. T., Thompson, H., and Waterhouse, J. A. H. (1967). Malignancy in adult coeliac disease, and idiopathic steatorrhoea. American Journal of Medicine, 42, 899-912.","journal-title":"Gut; Malignancy in adult coeliac disease, and idiopathic steatorrhoea"},{"key":"ref_7","first-page":"339","article-title":"Coeliac disease, malignancy, and a gluten-free diet","volume":"15","author":"Holmes, G.K.T.; Stokes, P.L.; McWalter, R.; Waterhouse, J.A.H.; Cooke, W.T.","year":"1974","unstructured":"Holmes, G. K. T., Stokes, P. L., McWalter, R., Waterhouse, J. A. H., and Cooke, W. T. (1974). Coeliac disease, malignancy, and a gluten-free diet. Gut, 15, 339.","journal-title":"Gut"},{"key":"ref_8","article-title":"Surface markers on human T and B lymphocytes","author":"Jondal, M.; Holm, G.; Wigzell, H.","year":"1972","unstructured":"Jondal, M., Holm, G., and Wigzell, H. (1972). Surface markers on human T and B lymphocytes."},{"issue":"207-21","key":"ref_9","first-page":"5","article-title":"A large population of lymphocytes forming non-immune rosettes with sheep red cells","volume":"136","author":"Lancaster-Smith, M.; Kumar, P.; Marks, R.; Clark, M.L.; Dawson, A.M.","year":"1974","unstructured":"A large population of lymphocytes forming non-immune rosettes with sheep red cells. Journal ofExperimental Medicine, 136, 207-21 5. Lancaster-Smith, M., Kumar, P., Marks, R., Clark, M. L., and Dawson, A. M. (1974). Jejunal mucosal immunoglobulin-containing cells and jejunal fluid immunoglobulins in adult coeliac disease and dermatitis herpetiformis. Gut, 15, 371-376.","journal-title":"Journal ofExperimental Medicine; Jejunal mucosal immunoglobulin-containing cells and jejunal fluid immunoglobulins in adult coeliac disease and dermatitis herpetiformis"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gut.16.9.683","article-title":"The cellular infiltrate of the jejunum in adult coeliac disease and dermatitis herpetiformis following the reintroduction of dietary gluten","volume":"16","author":"Lancaster-Smith, M.; Kumar, P.J.; Dawson, A.M.","year":"1975","unstructured":"Lancaster-Smith, M., Kumar, P. J., and Dawson, A. M. (1975). The cellular infiltrate of the jejunum in adult coeliac disease and dermatitis herpetiformis following the reintroduction of dietary gluten. Gut, 16, 683-688.","journal-title":"Gut"},{"key":"ref_11","first-page":"501","article-title":"Editorial. The coeliac philosophy","volume":"2","author":"Lancet","year":"1974","unstructured":"Lancet (1974). Editorial. The coeliac philosophy. Lancet, 2, 501-502.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/gut.7.2.140","article-title":"Lymphoreticular dysfunction in idiopathic steatorrhoea","volume":"7","author":"McCarthy, C.F.; Fraser, I.D.; Evans, K.T.; Read, A.E.","year":"1966","unstructured":"McCarthy, C. F., Fraser, I. D., Evans, K. T., and Read, A. E. (1966). Lymphoreticular dysfunction in idiopathic steatorrhoea. Gut, 7, 140-148.","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1136\/gut.12.10.794","article-title":"Impaired lymphocyte reactivity against tumour cells in patients with coeliac disease","volume":"12","author":"McClaurin, B.P.; Cooke, W.T.; Ling, N.R.","year":"1971","unstructured":"McClaurin, B. P., Cooke, W. T., and Ling, N. R. (1971). Impaired lymphocyte reactivity against tumour cells in patients with coeliac disease. Gut, 12, 794-800.","journal-title":"Gut"},{"key":"ref_14","article-title":"Studies of intestinal lymphoid tissue","author":"Marsh, M.N.","year":"1975","unstructured":"Marsh, M. N. (1975). Studies of intestinal lymphoid tissue."},{"key":"ref_15","first-page":"\"665","article-title":"Electron microscopic evidence of 'blast transformation' in epithelial lymphocytes of mouse small intestinal mucosa","volume":"16","author":"Rubin, W.; Fauci, A.S.; Sleisenger, M.H.; Jeffries, G.H.","year":"1965","unstructured":"Electron microscopic evidence of 'blast transformation' in epithelial lymphocytes of mouse small intestinal mucosa. Gut, 16, 665-674. Rubin, W., Fauci, A. S., Sleisenger, M. H., and Jeffries, G. H. (1965). Immunofluorescent studies in adult celiac disease. Journal of Clinical Investigation, 44, 475-485.","journal-title":"Gut; Immunofluorescent studies in adult celiac disease"},{"key":"ref_16","first-page":"823","article-title":"Enteric loss oflymphocytes in coeliac disease and in Crohn's disease","volume":"15","author":"Weetman, A.P.; Haggith, J.; Douglas, A.P.","year":"1974","unstructured":"Weetman, A. P., Haggith, J., and Douglas, A. P. (1974). Enteric loss oflymphocytes in coeliac disease and in Crohn's disease. Gut, 15, 823.","journal-title":"Gut"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1172\/JCI107267","article-title":"Thymus derived rosette forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections and other diseases","volume":"52","author":"Wybran, J.; Fudenberg, H.","year":"1973","unstructured":"Wybran, J., and Fudenberg, H. (1973). Thymus derived rosette forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections and other diseases. Journal of Clinical Investigation, 52, 1026-1032.","journal-title":"Journal of Clinical Investigation"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.17.5.328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:49:16Z","timestamp":1764996556000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.17.5.328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,5]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1976,5,1]]},"published-print":{"date-parts":[[1976,5]]}},"alternative-id":["10.1136\/gut.17.5.328"],"URL":"https:\/\/doi.org\/10.1136\/gut.17.5.328","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1976,5]]}}}