{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:52:03Z","timestamp":1764996723579,"version":"3.46.0"},"reference-count":23,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1976,9]]},"abstract":"<jats:p>A case is reported of a 43 year old man who suffered from a grass pollen allergy and a malabsorption syndrome and in whom a paraproteinaemia was found. The grass pollen hypersensitivity was abolished by desensitization. The malabsorption syndrome was found to be due to coeliac disease--that is, a \"flat\" mucosa of the jejunum with an almost normal ileal mucosa--followed by clinical recovery and morphological improvement on a gluten-free diet. A short period of gluten reintroduction caused deterioration of the jejunum. The monoclonal immunoglobulin (IgG-gamma) diminished and disappeared in the course of three years. Although it has not been possible to demonstrate that this paraprotein had anti-gliadin activity, it is suggested that the constant stimulation of the gut reticuloendothelial system by gluten might bear some relation to the appearance of the paraproteinaemia.<\/jats:p>","DOI":"10.1136\/gut.17.9.735","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"735-739","source":"Crossref","is-referenced-by-count":3,"title":["Transient paraproteinaemia in a patient with coeliac disease."],"prefix":"10.1136","volume":"17","author":[{"given":"A S","family":"Pena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J V","family":"Nieuwkoop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H R","family":"Schuit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W T","family":"Hekkens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Haex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1976,9,1]]},"reference":[{"key":"ref_1","first-page":"256","article-title":"Serum immunoglobulins and lymphocyte transformation studies in coeliac disease. Gut, 10,57-62. Combined Staff Clinic","volume":"44","author":"Blecher, T.E.; Brzechwa-Ajdukiewicz, A.; McCarthy, C.F.; Read, A.E.","year":"1969","unstructured":"Blecher, T. E., Brzechwa-Ajdukiewicz, A., McCarthy, C. F., and Read, A. E. (1969). Serum immunoglobulins and lymphocyte transformation studies in coeliac disease. Gut, 10,57-62. Combined Staff Clinic (1968). Plasma cell dyscrasias, current clinical and biochemical concepts. American Journal of Medicine, 44, 256-269.","journal-title":"American Journal of Medicine; Plasma cell dyscrasias, current clinical and biochemical concepts"},{"key":"ref_2","first-page":"777","article-title":"Essential paraproteinaemia","volume":"62","author":"Cooke, K.B.","year":"1969","unstructured":"Cooke, K. B. (1969). Essential paraproteinaemia. Proceedings of the Royal Society of Medicine, 62, 777-778.","journal-title":"Proceedings of the Royal Society of Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000458348","article-title":"Assay of intestinal disaccharidases","volume":"11","author":"Dahlqvist, A.","year":"1970","unstructured":"Dahlqvist, A. (1970). Assay of intestinal disaccharidases. Enzymologia Biologica et Clinica, 11, 52-66.","journal-title":"Enzymologia Biologica et Clinica"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1182\/blood.V14.10.1151.1151","article-title":"Leukemia and auto-immunization-some possible relationships","volume":"14","author":"Dameshek, W.; Schwartz, R.S.","year":"1959","unstructured":"Dameshek, W., and Schwartz, R. S. (1959). Leukemia and auto-immunization-some possible relationships. Blood, 14, 1151-1158.","journal-title":"Blood"},{"key":"ref_5","first-page":"13","article-title":"Coeliac disease, vasculitis, and cryoglobulinaemia","author":"Doe, W.F.; Evans, D.; Hobbs, J.R.; Booth, C.C.","year":"1972","unstructured":"Doe, W. F., Evans, D., Hobbs, J. R., and Booth, C. C. (1972). Coeliac disease, vasculitis, and cryoglobulinaemia. Gut, 13,112-123."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/jcp.25.3.243","article-title":"A method for the quantitation of small intestinal biopsy specimen","volume":"25","author":"Dunnill, M.S.; Whitehead, R.","year":"1972","unstructured":"Dunnill, M. S., and Whitehead, R. (1972). A method for the quantitation of small intestinal biopsy specimen. Journal of Clinical Pathology, 25, 243-246.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_7","first-page":"265","article-title":"Lymphocytes","volume-title":"Coeliac Disease","author":"Ferguson, A.","year":"1974","unstructured":"Ferguson, A. (1974). Lymphocytes. In Coeliac Disease, pp. 265-276. Edited by W. T. J. M. Hekkens and A. S. Pena. Medical and Technical Pub. Co.: Lancaster."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/gut.3.3.232","article-title":"Intestinal reticulosis as a complication of idiopathic steatorrhoea","volume":"3","author":"Gough, K.R.; Read, A.E.; Naish, J.M.","year":"1962","unstructured":"Gough, K. R., Read, A. E., and Naish, J. M. (1962). Intestinal reticulosis as a complication of idiopathic steatorrhoea. Gut, 3, 232-239.","journal-title":"Gut"},{"key":"ref_9","first-page":"42","article-title":"Malignancy in adult coeliac disease and idiopathic steatorrhoea","volume":"ofMedicine,","year":"1967","unstructured":"Harris, 0. D., Cooke, W. T., Thompson, H., and Waterhouse, J. A. H. (1967). Malignancy in adult coeliac disease and idiopathic steatorrhoea. Arnerican Journal ofMedicine, 42,899-912.","journal-title":"Arnerican Journal"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(68)90846-5","article-title":"Deficiency of gamma M-globulins in coeliac disease","volume":"1","author":"Hobbs, J.R.; Hepner, G.W.","year":"1968","unstructured":"Hobbs, J. R., and Hepner, G. W. (1968). Deficiency of gamma M-globulins in coeliac disease. Lancet, 1, 217-220.","journal-title":"Lancet"},{"key":"ref_11","first-page":"649","article-title":"Immunological mystery of coeliac disease","volume":"2","year":"1969","unstructured":"Hobbs, J. R., Hepner, G. W., Douglas, A. P., Crabb6, P. A., and Johansson, S. G. 0. (1969). Immunological mystery of coeliac disease. Lancet, 2, 649-650.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/gut.7.2.140","article-title":"Lymphoreticular dysfunction in idiopathic steatorrhoea","volume":"7","author":"McCarthy, C.F.; Fraser, I.D.; Evans, K.T.; Read, A.E.","year":"1966","unstructured":"McCarthy, C. F., Fraser, I. D., Evans, K. T., and Read, A. E. (1966). Lymphoreticular dysfunction in idiopathic steatorrhoea. Gut, 7, 140-148.","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0002-9343(69)90198-3","article-title":"Myeloma proteins and antibodies","volume":"47","author":"Metzger, H.","year":"1969","unstructured":"Metzger, H. (1969). Myeloma proteins and antibodies. American Journal of Medicine, 47, 837-844.","journal-title":"American Journal of Medicine"},{"key":"ref_14","first-page":"392","article-title":"Depletion of thymus-dependent lymphocytes in adult coeliac disease","volume":"16","author":"O'Donoghue, D.P.; Lancaster-Smith, M.; Kumar, P.J.","year":"1975","unstructured":"O'Donoghue, D. P., Lancaster-Smith, M., and Kumar, P. J. (1975). Depletion of thymus-dependent lymphocytes in adult coeliac disease. Gut, 16, 392-393.","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0140-6736(70)91859-3","article-title":"Repeated stimulation of the reticulo-endothelial system and the development of plasma-cell dyscrasias","volume":"1","author":"Penny, R.; Hughes, S.","year":"1970","unstructured":"Penny, R., and Hughes, S. (1970). Repeated stimulation of the reticulo-endothelial system and the development of plasma-cell dyscrasias. Lancet, 1, 77-78.","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1182\/blood.V25.5.736.736","article-title":"The development of a myeloma-like condition in mink with Aleutian disease","volume":"25","author":"Porter, D.D.; Dixon, F.J.; Larsen, A.E.","year":"1965","unstructured":"Porter, D. D., Dixon, F. J., and Larsen, A. E. (1965). The development of a myeloma-like condition in mink with Aleutian disease. Blood, 25, 736-742.","journal-title":"Blood"},{"key":"ref_17","first-page":"541","volume-title":"Immunoselection technique and its applications. In Protides of the Biological Fluids","volume":"19","author":"Radl, J.","year":"1972","unstructured":"Radl, J. (1972). Immunoselection technique and its applications. In Protides of the Biological Fluids, vol. 19, pp. 541-545. Edited by H. Peeters. Pergamon Press: Oxford."},{"key":"ref_18","first-page":"405","article-title":"Immune system disorders in man and in experimental models accompanied by the production of homogeneous immunoglobulins-paraproteins","volume-title":"Protides of the Biological Fluids","volume":"23","author":"Radl, J.","year":"1975","unstructured":"Radl, J. (1975). Immune system disorders in man and in experimental models accompanied by the production of homogeneous immunoglobulins-paraproteins. In Protides of the Biological Fluids, vol. 23, pp. 405-408. Edited by H. Peeters.Pergamon Press,: Oxford."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0140-6736(66)90749-5","article-title":"Paraproteins in folic-acid deficiency","volume":"1","author":"Roman, W.; Coles, M.","year":"1966","unstructured":"Roman, W., and Coles, M. (1966). Paraproteins in folic-acid deficiency. Lancet, 1, 211-212.","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/bmj.2.5757.321-a","article-title":"Natural history of monoclonal immunoglobulins","volume":"2","author":"Seligmann, M.; Danon, F.; Clauvel, J.P.","year":"1971","unstructured":"Seligmann, M., Danon, F., and Clauvel, J. P. (1971). Natural history of monoclonal immunoglobulins. British Medical Journal, 2, 321-322.","journal-title":"British Medical Journal"},{"key":"ref_21","first-page":"823","article-title":"Enteric loss of lymphocytes in coeliac disease and in Crohn's disease","volume":"15","author":"Weetman, A.P.; Haggith, J.; Douglas, A.P.","year":"1974","unstructured":"Weetman, A. P., Haggith, J., and Douglas, A. P. (1974) Enteric loss of lymphocytes in coeliac disease and in Crohn's disease. Gut, 15, 823.","journal-title":"Gut"},{"key":"ref_22","first-page":"131","article-title":"Principles and methods for the morphometric study of the lung and other organs","volume":"12","author":"Weibel, E.R.","year":"1963","unstructured":"Weibel, E. R. (1963). Principles and methods for the morphometric study of the lung and other organs. Laboratory Investigation, 12, 131-155.","journal-title":"Laboratory Investigation"},{"key":"ref_23","first-page":"778","article-title":"Transient paraproteins","volume":"62","author":"Young, V.H.","year":"1969","unstructured":"Young, V. H. (1969). Transient paraproteins. Proceedings of the Royal Society ofMedicine, 62, 778-780.","journal-title":"Proceedings of the Royal Society ofMedicine"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.17.9.735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:40:27Z","timestamp":1764996027000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.17.9.735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,9]]},"references-count":23,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1976,9,1]]},"published-print":{"date-parts":[[1976,9]]}},"alternative-id":["10.1136\/gut.17.9.735"],"URL":"https:\/\/doi.org\/10.1136\/gut.17.9.735","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1976,9]]}}}