{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T13:32:04Z","timestamp":1765632724227,"version":"3.48.0"},"reference-count":15,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1977,10]]},"abstract":"<jats:p>Nineteen healthy subjects were studied and 17 patients with gastric ulcer before and after ulcer healing with carbenoxolone. Gastric deoxytibonucleic acid (DNA) loss was measured as an index of epithelial cell turnover, and N-acetylneuraminic acid (NANA) content of gastric juice as an index of mucus secretion. In normal subjects there was a negative correlation (p less that 0-025) between gastric DNA loss and NANA secretion; the lower the cell turnover the higher the NANA production. In gastric ulcer patients DNA loss or turnover was significantly (p less than 0-01) higher than normal, and fell significantly (p less than 0-01) after four weeks' treatment with carbenoxolone when 16 of the 17 ulcers had healed. At the same time NANA output increased significantly (p less than 0-01). It is suggested that patients with gastric ulcer lose cells at a high rate, a state of affairs which is returned towards normal by carbenoxolone, thus allowing the epithelial cells to mature within the mucosa and produce more mucus.<\/jats:p>","DOI":"10.1136\/gut.18.10.817","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"817-820","source":"Crossref","is-referenced-by-count":38,"title":["Gastric epithelial cell turnover, mucus production, and healing of gastric ulcers with carbenoxolone."],"prefix":"10.1136","volume":"18","author":[{"given":"W","family":"Domschke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Domschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Demling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D N","family":"Croft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1042\/bj0810384","article-title":"Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids","volume":"81","author":"Aminoff, D.","year":"1961","unstructured":"Aminoff, D. (1961). Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. Biochemical Journal, 81, 384-392.","journal-title":"Biochemical Journal"},{"key":"ref_2","first-page":"867","article-title":"Studies in the rates of epithelial cell exfoliation from gastric mucosa in normal and in ulcer subjects","volume":"12","author":"Boyes, B.E.; Crean, G.P.; Watkinson, G.","year":"1971","unstructured":"Boyes, B. E., Crean, G. P., and Watkinson, G. (1971). Studies in the rates of epithelial cell exfoliation from gastric mucosa in normal and in ulcer subjects. Gut, 12, 867.","journal-title":"Gut"},{"issue":"315323","key":"ref_3","article-title":"A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid","volume":"62","author":"Burton, K.","year":"1956","unstructured":"Burton, K. (1956). A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochemnical Journal, 62,315323.","journal-title":"Biochemnical Journal"},{"key":"ref_4","first-page":"58","article-title":"Gastritis-cell turnover studies","volume-title":"Topics in Gastroenterology","author":"Croft, D.N.","year":"1973","unstructured":"Croft, D. N. (1973). Gastritis-cell turnover studies. In Topics in Gastroenterology, pp. 58-64. Edited by S. C. Truelove and D. P. Jewell. Blackwell: Oxford."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1042\/bj0950612","article-title":"The estimation of deoxyribonucleic acid in the presence of sialic acid; application to analysis of human gastric washings","volume":"95","author":"Croft, D.N.; Lubran, M.","year":"1965","unstructured":"Croft, D. N., and Lubran, M. (1965). The estimation of deoxyribonucleic acid in the presence of sialic acid; application to analysis of human gastric washings. Biochemical Journal, 95, 612-620.","journal-title":"Biochemical Journal"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1136\/gut.7.4.333","article-title":"Cell loss from human gastric mucosa measured by the estimation of deoxyribonucleic acid in gastric washings","volume":"7","author":"Croft, D.N.; Pollock, D.J.; Coghill, N.F.","year":"1966","unstructured":"Croft, D. N., Pollock, D. J., and Coghill, N. F. (1966). Cell loss from human gastric mucosa measured by the estimation of deoxyribonucleic acid in gastric washings. Gut, 7, 333-343.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3109\/00365527209180971","article-title":"Some properties of mucus in patients with gastric ulcer. Effect of treatment with carbenoxolone sodium","volume":"7","author":"Domschke, W.; Domschke, S.; Classen, M.; Demling, L.","year":"1972","unstructured":"Domschke, W., Domschke, S., Classen, M., and Demling, L. (1972). Some properties of mucus in patients with gastric ulcer. Effect of treatment with carbenoxolone sodium. Scandinavian Journal of Gastroenterology, 7, 647-651.","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"ref_8","first-page":"511","article-title":"Experimentelle und klinische Untersuchungen zum Mechanismus der Carbenoxolonwirkung. I. Einfluss von Carbenoxolon auf die Magensaft-Mucus-Sekretion der Ratte","volume":"77","author":"Gbeorghiu, Th; Frotz, H.; Klein, H.J.","year":"1971","unstructured":"Gbeorghiu, Th., Frotz, H., and Klein, H. J. (1971). Experimentelle und klinische Untersuchungen zum Mechanismus der Carbenoxolonwirkung. I. Einfluss von Carbenoxolon auf die Magensaft-Mucus-Sekretion der Ratte. 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