{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:27:54Z","timestamp":1759541274856,"version":"3.44.0"},"reference-count":44,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1977,12]]},"abstract":"<jats:p>Total lymphocyte counts, B-, T-, C'3 receptor-bearing lymphocytes, and K-cell activity were studied in peripheral blood in patients with Crohn's disease and inflammatory liver disease. Patients with active untreated Crohn's disease and acute virus B hepatitis exhibited a markedly increased K-cell activity measured in a plaque assay when compared with normal controls (P less than 0.01). Patients with immunosuppressive treated Crohn's disease, HBsAg-positive chronic active hepatitis, and cirrhosis of the liver showed only a slight increase of K-cell activity (P less than 0.01). In the postacute phase of hepatitis (four to 12 weeks from onset) K-cell activity fell to normal levels. The number of B-lymphocytes showed a relative and absolute decrease in all groups of patients. With the exception of patients with acute HBsAg-positive hepatitis and the post-acute phase of hepatitis all the other groups showed statistically decreased absolute numbers for C'3 receptor-bearing lymphocytes. The significant decrease in K-cell activity and the number of T-lymphocytes in Crohn's disease treated with immunosuppressive drugs was interpreted as an effect of azathioprine and prednisone on these lymphocyte subpopulations.<\/jats:p>","DOI":"10.1136\/gut.18.12.1010","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1010-1016","source":"Crossref","is-referenced-by-count":21,"title":["K-lymphocytes (killer-cells) in Crohn's disease and acute virus B-hepatitis."],"prefix":"10.1136","volume":"18","author":[{"given":"R","family":"Eckhardt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Kloos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Dierich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K H","family":"Meyer zum B\u00fcschenfelde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,12,1]]},"reference":[{"key":"ref_1","first-page":"1072","article-title":"Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity","volume":"114","author":"Balow, J.E.; Hurley, D.L.; Fauci, A.S.","year":"1975","unstructured":"Balow, J. E., Hurley, D. L., and Fauci, A. S. (1975). Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity. Journal of Immnunology, 114, 1072-1076.","journal-title":"Journal of Immnunology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0300-5089(21)00289-3","article-title":"Evidence for a transmissible agent in Crohn's disease","volume":"5","author":"Beeken, W.L.; Mitchell, D.N.; Cave, D.R.","year":"1976","unstructured":"Beeken, W. L., Mitchell, D. N., and Cave, D. R. (1976). Evidence for a transmissible agent in Crohn's disease. 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Cellular hypersensitivity to components of intestinal mucosa in ulcerative colitis and Crohn's disease. Gut, 10, 631-636.","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/j.1365-3083.1975.tb03729.x","article-title":"A plaque technique for assay and characterization of antibody-dependent cytotoxic effector (K) cells","volume":"4","author":"Biberfeld, P.; WAhlin, B.; Perlmann, P.; Biberfeld, G.","year":"1975","unstructured":"Biberfeld, P., WAhlin, B., Perlmann, P., and Biberfeld, G. (1975). A plaque technique for assay and characterization of antibody-dependent cytotoxic effector (K) cells. 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The effector cell in antibody-induced cell-mediated immunity. Transplantation Reviews, 17, 108-149.","journal-title":"Transplantation Reviews"},{"issue":"1820-1823","key":"ref_17","first-page":"\"H0j,\" # \"91.\"","article-title":"Human lymphocyte cytotoxicity against mumps virus-infected target cells. Requirement for non-T cells","volume":"114","author":"Harfast, B.; Andersson, T.; Perlmann, P.","year":"1975","unstructured":"Harfast, B., Andersson, T., and Perlmann, P. (1975). Human lymphocyte cytotoxicity against mumps virus-infected target cells. Requirement for non-T cells. Journal of Immunology, 114, 1820-1823. H0j, L., and S0rensen, S. F. (1976). Lymphocyte subpopulations in chronic inflammatory bowel disease. 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Clinical and Experimental Immunology, 14, 219-226.","journal-title":"Clinical and Experimental Immunology"},{"key":"ref_23","first-page":"163","article-title":"Human lymphocyte subpopulations: classification according to surface markers and\/or functional characteristics","volume":"16","author":"Jondal, M.; Wigzell, H.; Aiuti, F.","year":"1973","unstructured":"Jondal, M., Wigzell, H., and Aiuti, F. (1973). Human lymphocyte subpopulations: classification according to surface markers and\/or functional characteristics. Transplantation Reviews, 16, 163-195.","journal-title":"Transplantation Reviews"},{"key":"ref_24","article-title":"Antibody-dependent cellular cytotoxicity","author":"Jondal, M.","year":"1976","unstructured":"Jondal, M. (1976). 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Journal of Immunology, 114, 116-1 19.","journal-title":"Journal of Immunology"},{"key":"ref_28","first-page":"\"1246","article-title":"Failure of certain cytotoxic lymphocytes to respond mitotically to phytohaemagglutinin","volume":"227","author":"MacLennan, I.C.M.; Harding, B.","year":"1970","unstructured":"MacLennan, I. C. M., and Harding, B. (1970). Failure of certain cytotoxic lymphocytes to respond mitotically to phytohaemagglutinin. Nature (London), 227, 1246-1248. Meyer zum Buischenfelde, K. H., Arnold, W., Knolle, J., and Hess, G. (1976). Immunreaktionen gegenuber HBsAg, HB&Ag und 'e'-Antigen bei akuter Virushepatitis sowie lebergesunden und leberkranken HBsAg-Tragern. 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Leucocyte migration studies in Crohn's disease using Crohn's colon homogenate and mitochondrial and microsomal fractions. Gut, 15, 19-23.","journal-title":"Gut"},{"key":"ref_37","first-page":"261","article-title":"Effect of Azathioprine and cytosine-arabinoside on humoral and cellular immunity in vitro","volume":"15","author":"Rollinghof, M.; Schrader, J.; Wagner, H.","year":"1973","unstructured":"Rollinghof, M., Schrader, J., and Wagner, H. (1973). Effect of Azathioprine and cytosine-arabinoside on humoral and cellular immunity in vitro. Clinical and Experimental Immunology, 15, 261-269.","journal-title":"Clinical and Experimental Immunology"},{"key":"ref_38","first-page":"187","article-title":"Reduced antibody-dependent cell-mediated cytotoxicity in systemic lupus erythematosus","volume":"20","author":"Schneider, J.; Chin, W.; Friou, G.J.; Cooper, S.M.; Harding, B.; Hill, R.L.; Quismorio, F.P.","year":"1975","unstructured":"Schneider, J., Chin, W., Friou, G. J., Cooper, S. 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