{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:02:34Z","timestamp":1765609354159,"version":"3.46.0"},"reference-count":16,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1977,3]]},"abstract":"<jats:p>Plasma levels of 25-hydroxyvitamin D (25-OHD) were found to be significantly reduced in a group of patients with small bowel resection when compared with normal controls. Plasma levels of 25-OHD after an oral dose of 25-hydroxyvitamin D3 (25-ohd3) were also reduced in the patient group. Dietary intake of vitamin D tended to be low in many patients, but seasonal variation of plasma 25-OHD levels indicated normal exposure to sunlight in most of the patients studied. It is suggested that these studies provide some evidence for malabsorption of 25-OHD after small bowel resection, which, it is postulated, may be due to interruption of the enterohepatic circulation of bile acids and of 25-OHD. These factors may contribute towards the low plasma levels of 25-OHD found in the patient group.<\/jats:p>","DOI":"10.1136\/gut.18.3.171","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"171-175","source":"Crossref","is-referenced-by-count":94,"title":["Plasma levels and intestinal absorption of 25-hydroxyvitamin D in patients with small bowel resection."],"prefix":"10.1136","volume":"18","author":[{"given":"J E","family":"Compston","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Creamer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,3,1]]},"reference":[{"key":"ref_1","unstructured":"of the enterohepatic circulation of bile acids after ileal resection could thus produce malabsorption of 25-OHD in the patients studied, most of whom had had large enough ileal resections to produce significant bile acid malabsorption. Recently, some direct evidence has been provided for an enterohepatic circulation of 25-OHD in man (Arnaud et al., 1975), and interruption of this circulation after small bowel resection may well lead to further faecal loss of 25-OHD. This continuous increased faecal loss of the metabolite may be important in the production of low plasma 25-OHD levels in these patients, particularly in the winter months when endogenous vitamin D synthesis is at a minimum.","article-title":"of the enterohepatic circulation of bile acids after ileal resection could thus produce malabsorption of 25-OHD in the patients studied, most of whom had had large enough ileal resections to produce significant bile acid malabsorption. Recently, some direct evidence has been provided for an enterohepatic circulation of 25-OHD in man (Arnaud et al., 1975), and interruption of this circulation after small bowel resection may well lead to further faecal loss of 25-OHD. This continuous increased faecal loss of the metabolite may be important in the production of low plasma 25-OHD levels in these patients, particularly in the winter months when endogenous vitamin D synthesis is at a minimum"},{"key":"ref_2","first-page":"570572","article-title":"25-hydroxyvitamin D3: evidence of an enterohepatic circulation in man","volume":"149","author":"Arnaud, S.B.; Goldsmith, R.S.; Lambert, P.W.; Go, V.L.W.","year":"1975","unstructured":"Arnaud, S. B., Goldsmith, R. S., Lambert, P. W., and Go, V. L. W. (1975). 25-hydroxyvitamin D3: evidence of an enterohepatic circulation in man. Proceedings of the Society for Experimental Biology and Medicine, 149, 570572.","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1172\/JCI105605","article-title":"Metabolism of vitamin D3-3H in human subjects: distribution in blood, bile, feces and urine","volume":"46","author":"Avioli, L.V.; Lee, S.W.; McDonald, J.E.; Lund, J.; DeLuca, H.F.","year":"1967","unstructured":"Avioli, L. V., Lee, S. W., McDonald, J. E., Lund, J., and DeLuca, H. F. (1967). Metabolism of vitamin D3-3H in human subjects: distribution in blood, bile, feces and urine. Journal of Clinical Investigation, 46, 983-992.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3891\/acta.chem.scand.21-1662","article-title":"Intestinal absorption and esterification of vitamin D3-1,2-3H in man","volume":"21","author":"Blomstrand, R.; Forsgren, L.","year":"1967","unstructured":"Blomstrand, R., and Forsgren, L. (1967). Intestinal absorption and esterification of vitamin D3-1,2-3H in man. Acta Chemica Scandinavica, 21, 1662-1663.","journal-title":"Acta Chemica Scandinavica"},{"key":"ref_5","article-title":"Competitive protein-binding assay for","author":"Edelstein, S.; Charman, M.; Lawson, D.E.M.; Kodicek, E.","year":"1974","unstructured":"Edelstein, S., Charman, M., Lawson, D. E. M., and Kodicek, E. (1974). Competitive protein-binding assay for 25-"},{"key":"ref_6","article-title":"The role played by bile in the absorption of vitamin D in the rat","author":"Greaves, J.D.; Schmidt, C.L.A.","year":"1933","unstructured":"Greaves, J. D., and Schmidt, C. L. A. (1933). The role played by bile in the absorption of vitamin D in the rat."},{"key":"ref_7","first-page":"101","article-title":"Journal ofBiological","volume":"102","unstructured":"Journal ofBiological Chemistry, 102, 101-112.","journal-title":"Chemistry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1210\/jcem-33-6-992","article-title":"Competitive proteinbinding radioassay for 25-hydroxycholecalciferol","volume":"33","author":"Haddad, J.G.; Chyu, K.J.","year":"1971","unstructured":"Haddad, J. G., and Chyu, K. J. (1971). Competitive proteinbinding radioassay for 25-hydroxycholecalciferol. 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Seasonal variations in serum 25-hydroxycholecalciferol in healthy people. Lancet, 1, 536-538.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1172\/JCI106168","article-title":"'Activation' of vitamin D by the liver","volume":"48","author":"Ponchon, G.; Kennan, A.L.; DeLuca, H.F.","year":"1969","unstructured":"Ponchon, G., Kennan, A. L., and DeLuca, H. F. (1969). 'Activation' of vitamin D by the liver. Journal of Clinical Investigation, 48, 2032-2037.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI104965","article-title":"Metabolism of vitamin D. I. Preparation of radioactive vitamin D and its intestinal absorption in the rat","volume":"43","author":"Schachter, D.; Finkelstein, J.D.; Kowarski, S.","year":"1964","unstructured":"Schachter, D., Finkelstein, J. D., and Kowarski, S. (1964). Metabolism of vitamin D. I. 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Nature, 247, 563-565.","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1172\/JCI105327","article-title":"Absorption of vitamin D3-3H in control subjects and patients with intestinal malabsorption","volume":"45","author":"Thompson, G.R.; Lewis, B.; Booth, C.C.","year":"1966","unstructured":"Thompson, G. R., Lewis, B., and Booth, C. C. (1966). Absorption of vitamin D3-3H in control subjects and patients with intestinal malabsorption. Journal of Clinical Investigation, 45, 94-102.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_16","first-page":"34","article-title":"Mechanisms of vitamin D deficiency in patients with lesions of the gastrointestinal tract","volume":"ofMedicine,","author":"Thompson, G.R.; Lewis, B.; Neale, G.; Booth, C.C.","year":"1965","unstructured":"Thompson, G. R., Lewis, B., Neale, G., and Booth, C. C. (1965). Mechanisms of vitamin D deficiency in patients with lesions of the gastrointestinal tract. 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