{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T05:51:04Z","timestamp":1765691464878,"version":"3.48.0"},"reference-count":30,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1977,5]]},"abstract":"<jats:p>Lysozyme (LZM) was identified in ulcerative colitis in granulocytes, monocytes, and macrophages of the intestinal lamina propria. In contrast with findings in normal colon or rectum, in ulcerative colitis LZM was also detected in some mucosal crypt cells and metaplastic Paneth cells. In both ulcerative colitis and Crohn's disease LZM was present in inflammatory cells of crypt abscesses. In Crohn's disease intense LZM staining was seen in epitheloid cell granulomas. The present observations permit one explanation for the raised concentration of serum-LZM in patients with ulcerative colitis and Crohn's disease.<\/jats:p>","DOI":"10.1136\/gut.18.5.377","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"377-381","source":"Crossref","is-referenced-by-count":24,"title":["Immunohistochemical identification of lysozyme in intestinal lesions in ulcerative colitis and Crohn's disease."],"prefix":"10.1136","volume":"18","author":[{"given":"M","family":"Klockars","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Reitamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Reitamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.0954-6820.1962.tb07168.x","article-title":"The cytology of colonic secretion in proctosigmoidal disease","volume":"172","author":"Anthonisen, P.; Riis, P.","year":"1962","unstructured":"Anthonisen, P., and Riis, P. (1962). The cytology of colonic secretion in proctosigmoidal disease. Acta Medica Scandinavica, 172, 375-381.","journal-title":"Acta Medica Scandinavica"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1126\/science.165.3892.454","article-title":"Mechanism of lysozyme action","volume":"165","author":"Chipman, D.M.; Sharon, N.","year":"1969","unstructured":"Chipman, D. M., and Sharon, N. (1969). Mechanism of lysozyme action. Science, 165, 454-465.","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1084\/jem.121.1.153","article-title":"The differentation of mononuclear phagocytes. Morphology, cytochemistry and biochemistry","volume":"121","author":"Cohn, Z.A.; Benson, B.","year":"1965","unstructured":"Cohn, Z. A., and Benson, B. (1965). The differentation of mononuclear phagocytes. Morphology, cytochemistry and biochemistry. Journal of Experimental Medicine, 121, 153-169.","journal-title":"Journal of Experimental Medicine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1136\/gut.16.12.985","article-title":"Serum lysozyme in inflammatory bowel disease","volume":"16","author":"Dronfield, M.W.; Langman, M.J.S.","year":"1975","unstructured":"Dronfield, M. W., and Langman, M. J. S. (1975). Serum lysozyme in inflammatory bowel disease. Gut, 16, 985-987.","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJM197502202920805","article-title":"Serum lysozyme in Crohn's disease and ulcerative colitis","volume":"292","author":"Falchuk, K.R.; Perrotto, J.L.; Isselbacher, K.J.","year":"1975","unstructured":"Falchuk, K. R., Perrotto, J.L., and Isselbacher, K. J. (1975a). Serum lysozyme in Crohn's disease and ulcerative colitis. New England Journal of Medicine, 292, 395-397.","journal-title":"New England Journal of Medicine"},{"key":"ref_6","first-page":"893","article-title":"Serum lysozyme in Crohn's disease. A useful index of disease activity","volume":"69","author":"Faichuk, K.R.; Perrotto, J.L.; Isselbacher, K.J.","year":"1975","unstructured":"Faichuk, K. R., Perrotto, J. L., and Isselbacher, K. J. (1975b). Serum lysozyme in Crohn's disease. A useful index of disease activity. Gastroenterology, 69, 893-896.","journal-title":"Gastroenterology"},{"key":"ref_7","article-title":"A histochemical study of human alimentary tract mucosubstances in health and disease","author":"Gad, A.","year":"1969","unstructured":"Gad, A. (1969). A histochemical study of human alimentary tract mucosubstances in health and disease."},{"key":"ref_8","first-page":"\"64","article-title":"The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney. Ultrastructural cytochemistry by a new technique","volume":"23","author":"conditions, Inflammatory","year":"1966","unstructured":"Inflammatory conditions. British Journal of Cancer, 23, 64-68. Graham, R. C., and Karnovsky, M. J. (1966). The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney. Ultrastructural cytochemistry by a new technique. Journal ofHistochernistry and Cytochemistry, 14, 291-302.","journal-title":"British Journal of Cancer"},{"key":"ref_9","first-page":"1","article-title":"Plasma lysozyme-A measure of neutrophil turnover. An analytical review","volume":"7","author":"Hansen, N.E.","year":"1974","unstructured":"Hansen, N. E. (1974). Plasma lysozyme-A measure of neutrophil turnover. An analytical review. Series Haematologica, 7, 1-87.","journal-title":"Series Haematologica"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1172\/JCI102655","article-title":"The role of the granulocyte as a source of lysozyme in ulcerative colitis","volume":"31","author":"Hiatt, R.B.; Engle, C.; Flood, C.; Karush, A.","year":"1952","unstructured":"Hiatt, R. B., Engle, C., Flood, C., and Karush, A. (1952). The role of the granulocyte as a source of lysozyme in ulcerative colitis. Journal of Clinical Investigation, 31, 721-726.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJM197601082940214","article-title":"Serum lysozyme levels in Crohn's disease and ulcerative colitis","volume":"294","author":"Hylander, E.; Hansen, N.E.; Karle, H.; Jarnum, S.","year":"1976","unstructured":"Hylander, E., Hansen, N. E., Karle, H., and Jarnum, S. (1976). Serum lysozyme levels in Crohn's disease and ulcerative colitis. New England Journal of Medicine, 294, 111.","journal-title":"New England Journal of Medicine"},{"key":"ref_12","first-page":"\"pp. 665","volume-title":"Vertebrate lysozymes. In The Enzymes","volume":"volume","author":"Imoto, T.; Johnson, L.N.; Noth, A.C.T.; Phillips, D.C.; Rupley, J.A.","year":"1972","unstructured":"Imoto, T., Johnson, L. N., Noth, A. C. T., Phillips, D. C., and Rupley, J. A. (1972). Vertebrate lysozymes. In The Enzymes, 3rd edn. pp. 665-868. volume 7. Edited by P. D. Boyer. Academic Press: New York.","edition":"3rd edn"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1056\/NEJM197602052940615","article-title":"Lysozyme in Crohn's disease: influence of methods","volume":"294","author":"Johansson, B.G.; Ursing, B.","year":"1976","unstructured":"Johansson, B. G., and Ursing, B. (1976). Lysozyme in Crohn's disease: influence of methods. New England Journal of Medicine, 294, 337.","journal-title":"New England Journal of Medicine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1136\/gut.15.12.953","article-title":"Indices of granulocyte activity in inflammatory bowel disease","volume":"15","author":"Kane, S.P.; Hoffbrand, A.V.; Neale, G.","year":"1974","unstructured":"Kane, S. P., Hoffbrand, A. V., and Neale, G. (1974). Indices of granulocyte activity in inflammatory bowel disease. Gut, 15, 953-959.","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1177\/23.12.1104708","article-title":"Tissue distribution of lysozyme in man","volume":"23","author":"Klockars, M.; Reitamo, S.","year":"1975","unstructured":"Klockars, M., and Reitamo, S. (1975). Tissue distribution of lysozyme in man. Journal of Histochemistry and Cytochemistry, 23, 932-940.","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000208029","article-title":"Stimulation of phagocytosis by human lysozyme","volume":"55","author":"Klockars, M.; Roberts, P.","year":"1976","unstructured":"Klockars, M., and Roberts, P. (1976). Stimulation of phagocytosis by human lysozyme. Acta Haematologica, 55, 289-295.","journal-title":"Acta Haematologica"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/gut.10.10.804","article-title":"The Paneth cell in disease","volume":"10","author":"Lewin, K.","year":"1969","unstructured":"Lewin, K. (1969). The Paneth cell in disease. Gut, 10, 804-811.","journal-title":"Gut"},{"key":"ref_18","first-page":"463","article-title":"A quantitative study of muramidase distribution in normal and nitrogen mustard-treated rats","volume":"45","author":"Lippman, M.E.; Finch, S.C.","year":"1972","unstructured":"Lippman, M. E., and Finch, S. C. (1972). A quantitative study of muramidase distribution in normal and nitrogen mustard-treated rats. Yale Journal ofBiology and Medicine, 45, 463-470.","journal-title":"Yale Journal ofBiology and Medicine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/jcp.28.2.124","article-title":"The distribution of muramidase (lysozyme) in human tissues","volume":"28","author":"Mason, D.Y.; Taylor, C.R.","year":"1975","unstructured":"Mason, D. Y., and Taylor, C. R. (1975). The distribution of muramidase (lysozyme) in human tissues. Journal of Clinical Pathology, 28, 124-132.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/17.9.563","article-title":"An immunoglobulin-enzyme bridge method for localizing tissue antigens","volume":"17","author":"Mason, T.E.; Phifer, R.F.; Spicer, S.S.; Swallow, R.A.; Dreskin, R.B.","year":"1969","unstructured":"Mason, T. E., Phifer, R. F., Spicer, S. S., Swallow, R. A., and Dreskin, R. B. (1969). An immunoglobulin-enzyme bridge method for localizing tissue antigens. Journal of Histochemistry and Cytochemnistry, 17, 563-569.","journal-title":"Journal of Histochemistry and Cytochemnistry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/243331a0","article-title":"Effects of lysozyme on normal and transformed mammalian cells","volume":"243","author":"Osserman, E.F.; Klockars, M.; Halper, J.; Fischel, R.E.","year":"1973","unstructured":"Osserman, E. F., Klockars, M., Halper, J., and Fischel, R. E. (1973). Effects of lysozyme on normal and transformed mammalian cells. Nature, 243, 331-335.","journal-title":"Nature"},{"key":"ref_22","first-page":"243","article-title":"Paneth cell metaplasia in ulcerative colitis","volume":"38","author":"Paterson, J.C.; Watson, S.H.","year":"1961","unstructured":"Paterson, J. C., and Watson, S. H. (1961). Paneth cell metaplasia in ulcerative colitis. American Journal of Pathology, 38, 243-249.","journal-title":"American Journal of Pathology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJM197506192922511","article-title":"Serum lysozyme levels in Crohn's disease","volume":"292","author":"Peeters, T.L.; Geboes, K.; Vantrappen, G.R.","year":"1975","unstructured":"Peeters, T. L., Geboes, K., and Vantrappen, G. R. (1975). Serum lysozyme levels in Crohn's disease. New England Journal of Medicine, 292, 1349.","journal-title":"New England Journal of Medicine"},{"key":"ref_24","first-page":"228","article-title":"Serum lysozyme in inflammatory bowel disease","volume":"2","author":"Pounder, R.E.; Avella, J.R.; McCallum, H.; J, Misiewicz J.","year":"1975","unstructured":"Pounder, R. E., Avella, J. R., McCallum, H., and Misiewicz J. J. (1975). Serum lysozyme in inflammatory bowel disease. Lancet, 2, 228-229.","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJM197509182931219","article-title":"Lysozyme in Crohn's disease","volume":"293","author":"l'ruzanski, W.; Marcon, N.","year":"1975","unstructured":"l'ruzanski, W., and Marcon, N. (1975). Lysozyme in Crohn's disease. New England Journal of Medicine, 293, 611-612.","journal-title":"New England Journal of Medicine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1177\/20.10.829","article-title":"Inhibition of erythrocyte pseudoperoxidase activity by treatment with hydrogen peroxide following methanol","volume":"20","author":"Streefkerk, J.G.","year":"1972","unstructured":"Streefkerk, J. G. (1972). Inhibition of erythrocyte pseudoperoxidase activity by treatment with hydrogen peroxide following methanol. Journal of Histochemistry and Cytochemistry, 20, 829-830.","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1083\/jcb.28.2.303","article-title":"Transformation of monocytes in tissue culture into macrophages, epithelioid cells and multinucleated giant cells","volume":"28","author":"Sutton, 3. S.; Weiss, L","year":"1966","unstructured":"Sutton, 3. S., and Weiss, L. (1966). Transformation of monocytes in tissue culture into macrophages, epithelioid cells and multinucleated giant cells. Journal of Cell Biology, 28, 303-332.","journal-title":"Journal of Cell Biology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/path.1700800214","article-title":"Paneth cells in the large intestine in ulcerative colitis","volume":"80","author":"Watson, A.J.; Roy, A.D.","year":"1960","unstructured":"Watson, A. J., and Roy, A. D. (1960). Paneth cells in the large intestine in ulcerative colitis. Journal of Pathology and Bacteriology, 80, 309-316.","journal-title":"Journal of Pathology and Bacteriology"},{"key":"ref_29","unstructured":"The April 1977 Issue","article-title":"The April 1977 Issue"},{"key":"ref_30","article-title":"ISSUE CONTAINS THE FOLLOWING PAPERS","author":"APRIL, T.H.E.","year":"1977","unstructured":"THE APRIL 1977 ISSUE CONTAINS THE FOLLOWING PAPERS"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.18.5.377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T05:50:31Z","timestamp":1765691431000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.18.5.377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,5]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1977,5,1]]},"published-print":{"date-parts":[[1977,5]]}},"alternative-id":["10.1136\/gut.18.5.377"],"URL":"https:\/\/doi.org\/10.1136\/gut.18.5.377","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1977,5]]}}}