{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:05:12Z","timestamp":1768896312382,"version":"3.49.0"},"reference-count":12,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1977,6]]},"abstract":"<jats:p>This paper presents the results of a pilot study to investigate whether the administration of a nocturnal dose of metiamide (the first orally active H2 receptor antagonist) would prevent or delay the relapse of duodenal ulceration after initial ulcer healing. Sixteen patients took part in a double-blind trial to compare metiamide (400 mg) with placebo. Endoscopically confirmed duodenal ulcer relapses occurred in two out of eight on metiamide and six out of eight on placebo. There was a significant prolongation of remission in those in those on the active drug with an apparent reduction in duodenitis.<\/jats:p>","DOI":"10.1136\/gut.18.6.438","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"438-441","source":"Crossref","is-referenced-by-count":8,"title":["Nocturnal metiamide treatment in the management of healed duodenal ulceration."],"prefix":"10.1136","volume":"18","author":[{"given":"M H","family":"Thompson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C W","family":"Venables","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/BF01070755","article-title":"Metiamide in the Zollinger-Ellison syndrome","volume":"20","author":"Blair, E.L.; Grund, E.R.; Miller, I.T.; Reed, J.D.; J., Sanders D.; Thompson, M.H.; Venables, C.W.","year":"1975","unstructured":"Blair, E. L., Grund, E. R., Miller, I. T., Reed, J. D., Sanders D. J., Thompson, M. H., and Venables, C. W. (1975). Metiamide in the Zollinger-Ellison syndrome. American Journal of Digestive Diseases, 20, 1123-1130.","journal-title":"American Journal of Digestive Diseases"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2125.1975.tb00564.x","article-title":"Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man","volume":"2","author":"Burland, W.L.; Duncan, W.A.M.; Hesselbo, T.; Mills, J.G.; Sharpe, P.C.; Haggie, S.J.; Wyllie, J.H.","year":"1975","unstructured":"Burland, W. L., Duncan, W. A. M., Hesselbo, T., Mills, J. G., Sharpe, P. C., Haggie, S. J., and Wyllie, J. H. (1975). Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man. British Journal of Clinical Pharmacology, 2, 481-486.","journal-title":"British Journal of Clinical Pharmacology"},{"key":"ref_3","first-page":"377","article-title":"Effect of the histamine H2 receptor antagonist cimetidine on vagally induced gastric secretion","volume":"3","author":"Carter, D.C.; Forrest, J.A.H.; R., Logan; Ansell, I.; Lidgard, G.; Heading, R.C.; Shearman, D.J.C.","year":"1975","unstructured":"Carter, D. C., Forrest, J. A. H., Logan. R., Ansell, I., Lidgard, G., Heading, R. C., and Shearman, D. J. C. (1975). Effect of the histamine H2 receptor antagonist cimetidine on vagally induced gastric secretion in man. I.R.C.S. Journal of Medical Science, 3, 377.","journal-title":"Journal of Medical Science"},{"key":"ref_4","first-page":"392","article-title":"Neutropenia Associated with metiamide","volume":"1","author":"Forrest, J.A.H.; Shearman, D.J.C.; Spence, R.; Celestin, L.R.","year":"1975","unstructured":"Forrest, J. A. H., Shearman, D. J. C., Spence, R., and Celestin, L. R. (1975). Neutropenia Associated with metiamide. Lancet, 1, 392-393.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(76)91859-6","article-title":"Treatment of duodenal ulcer with cimetidine","volume":"1","author":"Haggie, S.J.; Fermont, D.C.; Wyllie, J.H.","year":"1976","unstructured":"Haggie, S. J., Fermont, D. C., and Wyllie, J. H. (1976). Treatment of duodenal ulcer with cimetidine. Lancet, 1, 983-984.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1056\/NEJM197508212930802","article-title":"Inhibition of gastric acid secretion by cimetidine in patients with duodenal ulcer","volume":"293","author":"Henn, R.M.; Isenberg, J.I.; Maxwell, V.; Sturdevant, R.A.L.","year":"1975","unstructured":"Henn, R. M., Isenberg, J. I., Maxwell, V., and Sturdevant, R. A. L. (1975). Inhibition of gastric acid secretion by cimetidine in patients with duodenal ulcer. New England Journal of Medicine, 293, 371-375.","journal-title":"New England Journal of Medicine"},{"key":"ref_7","first-page":"181","article-title":"The role of gastric acidity in the pathogenesis of peptic ulcer","volume":"8","author":"James, A.H.; Pickering, G.W.","year":"1949","unstructured":"James, A. H., and Pickering, G. W. (1949). The role of gastric acidity in the pathogenesis of peptic ulcer. Clinical Science, 8, 181-210.","journal-title":"Clinical Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1001\/archsurg.1948.01240010352005","article-title":"Nocturnal gastric secretion","volume":"56","author":"Levin, E.; Kirsner, J.B.; Palmer, W.L.; Butler, C.","year":"1948","unstructured":"Levin, E., Kirsner, J. B., Palmer, W. L., and Butler, C. (1948). Nocturnal gastric secretion. Archives of Surgery, 56, 345-356.","journal-title":"Archives of Surgery"},{"key":"ref_9","first-page":"693","article-title":"Inhibition of nocturnal acid secretion in duodenal ulcer by one oral dose of metiamide","volume":"1","author":"Milton-Thompson, C.J.; Williams, J.G.; Jenkins, D.J.A.; Misiewicz, J.J.","year":"1974","unstructured":"Milton-Thompson, C. J., Williams, J. G., Jenkins, D. J. A., and Misiewicz, J. J. (1974). Inhibition of nocturnal acid secretion in duodenal ulcer by one oral dose of metiamide. Lancet, 1, 693-694.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/BF01070757","article-title":"Early clinical experience with metiamide. A histamine H2-receptor antagonist, in patients with duodenal ulcer","volume":"20","author":"Thompson, M.H.; Reed, J.D.; Dale, G.; Venables, C.W.","year":"1975","unstructured":"Thompson, M. H., Reed, J. D., Dale, G., and Venables, C. W. (1975). Early clinical experience with metiamide. A histamine H2-receptor antagonist, in patients with duodenal ulcer. American Journal of Digestive Diseases, 20, 1135-1141.","journal-title":"American Journal of Digestive Diseases"},{"key":"ref_11","first-page":"779","article-title":"Treatment of duodenal ulcer by metiamideA multicentre trial","volume":"2","author":"Lancet","year":"1975","unstructured":"Lancet (1975). Treatment of duodenal ulcer by metiamideA multicentre trial. Lancet, 2, 779-781.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/BF02999604","article-title":"169 studies in gastric secretion during the night","volume":"1","author":"Winkelstein, A.","year":"1935","unstructured":"Winkelstein, A. (1935). 169 studies in gastric secretion during the night. 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