{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:41:21Z","timestamp":1764996081619,"version":"3.46.0"},"reference-count":10,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1977,6]]},"abstract":"<jats:p>Jejunal absorption of sodium and water has been investigated in 10 normal Indians and 11 patients with chronic tropical sprue. Normal saline and solutions containing amino acids and dipeptides were studied. In both groups little absorption of sodium and water from normal saline was seen. Mean water and sodium absorption from the free amino acid or dipeptide solutions showed no significant difference between the groups and was similar to absorption from normal saline. These results differ from data obtained in normal English subjects where at these concentrations significant stimulation of sodium and water absorption was seen. In a proportion of subjects in both groups net secretion was observed. However, no correlation was seen between mucosal histology or luminal bacteriology and sodium or water movement. These findings in patients with chronic tropical sprue are similar to findings in normal Indians and suggest that jejunal handling of sodium and water is abnormal when compared with normal English subjects, but that the mucosa is not in a secretory phase as seen in certain other diarrhoeal states or in the acute early phase of sprue.<\/jats:p>","DOI":"10.1136\/gut.18.6.480","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"480-483","source":"Crossref","is-referenced-by-count":2,"title":["Intestinal perfusion studies in tropical sprue. 2. Movement of water and electrolytes."],"prefix":"10.1136","volume":"18","author":[{"given":"M D","family":"Hellier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Albert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S J","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1977,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/ajcn\/25.10.1047","article-title":"Tropical enteropathy and tropical sprue","volume":"25","author":"Baker, S.J.; Mathan, V.I.","year":"1972","unstructured":"Baker, S. J., and Mathan, V. I. (1972). Tropical enteropathy and tropical sprue. American Journal of Clinical Nutrition, 25, 1047-1055.","journal-title":"American Journal of Clinical Nutrition"},{"key":"ref_2","article-title":"Tropical sprue and malnutrition in West Bengal","author":"Banwell, J.G.; Gorbach, S.L.; Mitra, R.; Cassells, J.S.; Guha Mazumder, D.N.; Thomas, J.; Yardley, J.H.","year":"1970","unstructured":"Banwell, J. G., Gorbach, S. L., Mitra, R., Cassells, J. S., Guha Mazumder, D. N., Thomas, J., and Yardley, J. H. (1970). Tropical sprue and malnutrition in West Bengal."},{"key":"ref_3","first-page":"\"1559","article-title":"Fluid and electrolyte transport in the small intestine","volume":"23","author":"Bhat, P.; Shantakumari, S.; Rajan, D.; Mathan, V.I.; Kapadia, C.R.; Swarnabai, C.; Baker, S.J.","year":"1972","unstructured":"Fluid and electrolyte transport in the small intestine. American Journal of Clinical Nutrition, 23, 1559-1568. Bhat, P., Shantakumari, S., Rajan, D., Mathan, V. I., Kapadia, C. R., Swarnabai, C., and Baker, S. J. (1972). Bacterial flora of the gastrointestinal tract in Southern Indian control subjects and patients with tropical sprue. Gastroenterology, 62, 11-21.","journal-title":"American Journal of Clinical Nutrition; Bacterial flora of the gastrointestinal tract in Southern Indian control subjects and patients with tropical sprue"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0016-5085(19)33098-7","article-title":"Intestinal perfusion studies in tropical sprue. I. Transport of water, electrolytes and d-xylose","volume":"65","author":"Corcino, J.J.; Maldonado, M.; Klipstein, F.A.","year":"1973","unstructured":"Corcino, J. J., Maldonado, M., and Klipstein, F. A. (1973). Intestinal perfusion studies in tropical sprue. I. Transport of water, electrolytes and d-xylose. Gastroenterology, 65, 192-198.","journal-title":"Gastroenterology"},{"key":"ref_5","article-title":"Medical Microbiology","author":"Cruickshank, R.","year":"1965","unstructured":"Cruickshank, R. (Ed). (1965). Medical Microbiology. 11th edn. Livingstone: Edinburgh.","edition":"11th edn"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/bmj.4.5738.782","article-title":"Dipeptide absorption in cystinuria","volume":"4","author":"Hellier, M.D.; Perrett, D.; Holdsworth, C.D.","year":"1970","unstructured":"Hellier, M. D., Perrett, D., and Holdsworth, C. D. (1970). Dipeptide absorption in cystinuria. British Medical Journal, 4, 782-783.","journal-title":"British Medical Journal"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/bmj.1.6003.186","article-title":"Intestinal absorption in normal Indian and English people","volume":"1","author":"Hellier, M.D.; Radhakrishnan, A.N.; Ganapathy, V.; Gammon, A.; Baker, S.J.","year":"1976","unstructured":"Hellier, M. D., Radhakrishnan, A. N., Ganapathy, V., Gammon, A., and Baker, S. J. (1976a) Intestinal absorption in normal Indian and English people. British Medical Journal, 1, 186-188.","journal-title":"British Medical Journal"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1136\/gut.17.7.511","article-title":"Intestinal perfusion studies in tropical sprue. I. Amino acid and dipeptide absorption","volume":"17","author":"Hellier, M.D.; Radhakrishnan, A.N.; Ganapathy, V.; Mathan, V.I.; Baker, S.J.","year":"1976","unstructured":"Hellier, M. D., Radhakrishnan, A. N., Ganapathy, V., Mathan, V. I., and Baker, S. J. (1976b). Intestinal perfusion studies in tropical sprue. I. Amino acid and dipeptide absorption. Gut, 17, 511-516.","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/gut.14.1.41","article-title":"The effect of amino acids and dipeptides on sodium and water absorption in man","volume":"14","author":"Hellier, M.D.; Thirumalai, C.; Holdsworth, C.D.","year":"1973","unstructured":"Hellier, M. D., Thirumalai, C., and Holdsworth, C. D. (1973). The effect of amino acids and dipeptides on sodium and water absorption in man. Gut, 14, 41-45.","journal-title":"Gut"},{"key":"ref_10","first-page":"139","article-title":"A turbidimetric method for the determination of higher polyethylene glycol in biological materials","volume":"22","author":"Hyden, S.","year":"1955","unstructured":"Hyden, S. (1955). A turbidimetric method for the determination of higher polyethylene glycol in biological materials. Annales Agriculturae Fenniae, 22, 139-145.","journal-title":"Annales Agriculturae Fenniae"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.18.6.480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:09:29Z","timestamp":1764994169000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.18.6.480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,6]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1977,6,1]]},"published-print":{"date-parts":[[1977,6]]}},"alternative-id":["10.1136\/gut.18.6.480"],"URL":"https:\/\/doi.org\/10.1136\/gut.18.6.480","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1977,6]]}}}