{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:42:00Z","timestamp":1759542120774,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1977,9]]},"abstract":"<jats:p>Eighty-six patients with duodenal ulcer were treated in a multicentre controlled trial with carbenoxolone capsules (Duogastrone, 50 mg four times a day for six weeks) or a placebo. Sixty-nine patients accepted endoscopy at the beginning and end of the treatment. Symptomatic responses and endoscopic improvement were significantly greater in those receiving the active preparation than in those receiving the control capsules, complete, endoscopically assessed, healing being achieved in 65% and 20%, respectively, of individuals having accepted endoscopy, after six weeks' treatment. Side-effects of salt and water retention or hypokalaemia were noted in over a quarter of those receiving the carbenoxolone capsules, but none of the adverse effects was severe enough to necessitate withdrawal of treatment.<\/jats:p>","DOI":"10.1136\/gut.18.9.717","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"717-720","source":"Crossref","is-referenced-by-count":11,"title":["Carbenoxolone sodium capsules in the treatment of duodenal ulcer. An endoscopic controlled trial."],"prefix":"10.1136","volume":"18","member":"239","published-online":{"date-parts":[[1977,9,1]]},"reference":[{"key":"ref_1","first-page":"251","article-title":"Multicentre double-blind study","volume-title":"of Duogastrone in the treatment of duodenal ulcers. In 4th Symnposium on Carbenoxolone Sodium","author":"Archambault, A.; Farley, A.; Gosselin, D.; Martin, F.","year":"1975","unstructured":"Archambault, A., Farley, A., Gosselin, D., and Martin, F. (1975). Multicentre double-blind study of Duogastrone in the treatment of duodenal ulcers. In 4th Symnposium on Carbenoxolone Sodium, pp. 251-255. Edited by F. Avery-Jones and D. V. Parke. Butterworths: London."},{"year":"1972","author":"Brown, P.; Salmon, P.R.; Htut, T.; Read, A.E.","key":"ref_2","unstructured":"Brown, P., Salmon, P. R., Htut, T., and Read, A. E. (1972)."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1136\/bmj.3.5828.661","article-title":"A double-blind trial of carbenoxolone sodium capsules in duodenal ulcer therapy, based on endoscopic diagnosis","volume":"3","unstructured":"A double-blind trial of carbenoxolone sodium capsules in duodenal ulcer therapy, based on endoscopic diagnosis. 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Gastroenterology, 62, 6-10.","journal-title":"Gastroenterology"},{"key":"ref_6","first-page":"209","article-title":"Carbenoxolone capsules","volume-title":"(Duogastrone) in duodenal ulcer: preliminary results of clinical and experimental studies. In Symposium on Carbenoxolone Sodium","author":"Robson, J.M.; Colin-Jones, D.G.; Lennard Jones, J.E.; Howel Jones, J.; Misiewicz, J.J.; Langman, M.J.S.","year":"1968","unstructured":"Colin-Jones, D. G., Lennard Jones, J. E., Howel Jones, J., Misiewicz, J. J., and Langman, M. J. S. (1968). Carbenoxolone capsules (Duogastrone) in duodenal ulcer: preliminary results of clinical and experimental studies. In Symposium on Carbenoxolone Sodium, pp. 209-216. Edited by J. M. Robson and F. M. Sullivan. Butterworths: London."},{"year":"1967","author":"Craig, O.; Hunt, T.; Kimerling, J.J.; Parke, D.V.","key":"ref_7","unstructured":"Craig, O., Hunt, T., Kimerling, J. J., and Parke, D. V. (1967)."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/gut.11.7.559","article-title":"A controlled trial of glycopyrronium and 1-hyoscyamine in the long-term treatment of duodenal ulcer","volume":"11","author":"Kaye, M.D.; Rhodes, J.; Beck, P.; Sweetnan, P.M.; Davies, G.T.; Evans, K.T.","year":"1970","unstructured":"Kaye, M. D., Rhodes, J., Beck, P., Sweetnan, P. M., Davies, G. T., and Evans, K. T. (1970). A controlled trial of glycopyrronium and 1-hyoscyamine in the long-term treatment of duodenal ulcer. Gut, 11, 559-566.","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/gut.9.6.704","article-title":"A controlled trial of carbenoxolone sodium capsules in the treatment of duodenal ulcer","volume":"9","author":"Montgomery, R.D.; Lawrence, I.H.; Manton, D.J.; Mendl, K.; Rowe, P.","year":"1968","unstructured":"Montgomery, R. D., Lawrence, I. H., Manton, D. J., Mendl, K., and Rowe, P. (1968). A controlled trial of carbenoxolone sodium capsules in the treatment of duodenal ulcer. Gut, 9, 704-706.","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/BF02237730","article-title":"Long-term anticholinergic therapy for prevention of recurrences in duodenal ulcer","volume":"9","author":"Sun, D.C.H.","year":"1964","unstructured":"Sun, D. C. H. (1964). Long-term anticholinergic therapy for prevention of recurrences in duodenal ulcer. American Journal of Digestive Diseases, 9, 706-716.","journal-title":"American Journal of Digestive Diseases"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0016-5085(70)80146-9","article-title":"A controlled study on the use of propantheline and amylopectin sulfate (SN-263) for recurrences in duodenal ulcer","volume":"58","author":"Sun, D.C.H.; Ryan, M.L.","year":"1970","unstructured":"Sun, D. C. H., and Ryan, M. L. (1970). A controlled study on the use of propantheline and amylopectin sulfate (SN-263) for recurrences in duodenal ulcer. Gastroenterology, 58, 756-761.","journal-title":"Gastroenterology"},{"key":"ref_12","first-page":"12","article-title":"The effect of glycopyrrolate on the course of symptomatic duodenal ulcer","author":"Trevino, H.; Anderson, J.; Davey, P.G.; Henley, K.S.","year":"1967","unstructured":"Trevino, H., Anderson, J., Davey, P. G., and Henley, K. S. (1967). The effect of glycopyrrolate on the course of symptomatic duodenal ulcer. American Journal of Digestive Diseases, 12,983-987.","journal-title":"American Journal of Digestive Diseases"},{"key":"ref_13","article-title":"Studies in pectic ulcer disease with special reference to the effect of 1-hyoscyamine","author":"Walan, A.","year":"1970","unstructured":"Walan, A. (1970). Studies in pectic ulcer disease with special reference to the effect of 1-hyoscyamine. Acta Medica","journal-title":"Acta Medica"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.18.9.717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:44:03Z","timestamp":1757313843000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.18.9.717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,9]]},"references-count":13,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1977,9,1]]},"published-print":{"date-parts":[[1977,9]]}},"alternative-id":["10.1136\/gut.18.9.717"],"URL":"https:\/\/doi.org\/10.1136\/gut.18.9.717","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1977,9]]}}}