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In a group of 50 patients with cirrhosis, the ratio was significantly lowered (P less than 0.001) irrespective of the presence of hepatic encephalopathy. A good correlation existed between the value of the ratio and the severity of the liver disease as judged histologically, with values of the ratio appearing to reflect histological change irrespective of the patient's clinical condition. There was no significant diurnal variation in the value of the ratio. Lowering of this plasma amino acid ratio appears to be secondary to liver disease and quite independent of the presence of hepatic encephalopathy.<\/jats:p>","DOI":"10.1136\/gut.19.11.1068","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1068-1073","source":"Crossref","is-referenced-by-count":166,"title":["Plasma ratio of valine, leucine and isoleucine to phenylalanine and tyrosine in liver disease."],"prefix":"10.1136","volume":"19","author":[{"given":"M Y","family":"Morgan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Milsom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sherlock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/newbio245025a0","article-title":"Serotonin metabolism in rat brain after surgical diversion of the portal venous circulation","volume":"245","author":"Baldessarini, R.J.; Fischer, J.E.","year":"1973","unstructured":"Baldessarini, R. 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